Results 21 to 30 of about 1,871,872 (166)

Extracellular vesicle mimetics as delivery vehicles for oligonucleotide-based therapeutics and plasmid DNA

Frontiers in Bioengineering and Biotechnology
IntroductionSmall membrane particles called extracellular vesicles (EVs) transport biologically active cargo between cells, providing intercellular communication.
Anastasiya Oshchepkova, Ivan Chernikov, Svetlana Miroshnichenko, Olga Patutina, Oleg Markov, Innokenty Savin, Yaroslav Staroseletz, Mariya Meschaninova, Pavel Puchkov, Sergey Zhukov, Maxim Kupryushkin, Mikhail Maslov, Aleksandra Sen’kova, Valentin Vlassov, Elena Chernolovskaya, Marina Zenkova   +15 more
doaj   +1 more source

Types of Acid and Drying Method Differently Affect the Chemical Profile of Sodium Caseinate

Journal of Food Quality and Hazards Control, 2021
Background: Sodium caseinate is a rich source of protein and minerals originating from animals. Numerous food and non-food products are made from sodium caseinate.
F. Maruddin, R. Malaka, S. Sabil, S. Baba, H. Amqam, M. Taufik   +5 more
doaj  

Effects of Hop Bitter Acids, Bitter Components in Beer, on Cognition in Healthy Adults: A Randomized Controlled Trial [PDF]

Journal of Agricultural and Food Chemistry, 2019
The present study aimed to investigate the effects of matured hop bitter acids (MHBAs) on human cognition, mental fatigue, and mood state. In this randomized double-blind placebo-controlled study, 60 healthy adults (age 45-64 years) with self-awareness of cognitive decline were randomly divided into 2 groups and received either orally administered ...
Takafumi Fukuda, Kuniaki Obara, Jiro Saito, Satoshi Umeda, Yasuhisa Ano   +4 more
openaire   +2 more sources

Optimization of Bifunctional Antisense Oligonucleotides for Regulation of Mutually Exclusive Alternative Splicing of PKM Gene

Molecules, 2022
Oligonucleotide tools, as modulators of alternative splicing, have been extensively studied, giving a rise to new therapeutic approaches. In this article, we report detailed research on the optimization of bifunctional antisense oligonucleotides (BASOs),
Natalia Bartyś, Anna Pasternak, Jolanta Lisowiec-Wąchnicka   +2 more
doaj   +1 more source

A Comprehensive Analysis of the Thrombin Binding Aptamer Containing Functionalized Pyrrolo-2’-deoxycytidines

Pharmaceuticals, 2021
Aptamers constitute an answer for the growing need for targeted therapy development. One of the most well-known representatives of this group of compounds is thrombin binding aptamers (TBA) targeted towards thrombin.
Weronika Kotkowiak, Zofia Jahnz-Wechmann, Anna Pasternak   +2 more
doaj   +1 more source

Deciphering the tRNA-derived small RNAs: origin, development, and future

Cell Death and Disease, 2021
Transfer RNA (tRNA)-derived small RNAs (tsRNAs), a novel category of small noncoding RNAs, are enzymatically cleaved from tRNAs. Previous reports have shed some light on the roles of tsRNAs in the development of human diseases.
Bowen Liu, Jinling Cao, Xiangyun Wang, Chunlei Guo, Yunxia Liu, Tianjiao Wang   +5 more
doaj   +1 more source

Characterization of Benitaka Grape Pomace (Vitis vinifera L.): An Analysis of Its Properties for Future Biorefinery Applications

Waste
This study investigates the properties of Benitaka grape pomace (Vitis vinifera L.), a byproduct of the wine industry, focusing on its potential for applications in the circular economy and biorefinery processes.
Luiz Eduardo Nochi Castro, Tiago Linhares Cruz Tabosa Barroso, Vanessa Cosme Ferreira, Tânia Forster Carneiro   +3 more
doaj   +1 more source

Towards improved anticancer properties of the G-quadruplex-forming T40231 aptamer through increased flexibility of nucleoside residues

Scientific Reports
In this article, the T40231 aptamer, an anticancer agent, originally known for its ability to inhibit STAT3, was altered with UNAs to enhance its flexibility in the loops or G-tetrads.
Weronika Kotkowiak, Natalia Bartyś, Anna Pasternak   +2 more
doaj   +1 more source

Electronic Tongue Response to Chemicals in Orange Juice that Change Concentration in Relation to Harvest Maturity and Citrus Greening or Huanglongbing (HLB) Disease

Sensors, 2015
In an earlier study, an electronic tongue system (e-tongue) has been used to differentiate between orange juice made from healthy fruit and from fruit affected by the citrus greening or Huanglongbing (HLB) disease. This study investigated the reaction of
Smita Raithore, Jinhe Bai, Anne Plotto, John Manthey, Mike Irey, Elizabeth Baldwin   +5 more
doaj   +1 more source

Quest for space: Tenacity of DNA, Protein, and Lipid macromolecules in intracellular crowded environment

Biomolecular Concepts
The biochemical processes in the cellular milieu involving biomacromolecular interaction usually occur in crowded and heterogeneous environments, impacting their structure, stability, and reactivity.
Phogat Priyanka, Bansal Aparna, Nain Nishu, Khan Shoaib, Saso Luciano, Kukreti Shrikant   +5 more
doaj   +1 more source