Results 141 to 150 of about 2,767,776 (309)
Collectivity of 0\u3csup\u3e+\u3c/sup\u3e States in \u3csup\u3e160\u3c/sup\u3eGd
, 2015 Excited 0+ states in 160Gd have been examined with the (n,n′γ) reaction at incident neutron energies up to 2.8 MeV. Gamma-ray excitation functions and angular distribution measurements allow the confirmation of the existence of 0+ states at 1379.70 keV ...
Aprahamian, A. +12 more
core +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Site-Specific Oxidation State Assignments of the Iron Atoms in the [4Fe:4S]2+/1+/0 States of the Nitrogenase Fe-Protein. [PDF]
Angew Chem Int Ed Engl, 2019 Wenke BB, Spatzal T, Rees DC.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
European Physical Journal C: Particles and FieldsIn this work, we calculate the magnetic moments of the $$P^{N^{0}}_{\psi }$$ P ψ N 0 states and $$P^{\Delta ^{0}}_{\psi }$$ P ψ Δ 0 states with valence quark content $${\bar{c}}cudd $$ c ¯ c u d d in molecular model, diquark–diquark–antiquark model and ...
Fei Guo, Hao-Song Li
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
New insights into the doubly charmed exotic mesons
European Physical Journal C: Particles and FieldsUsing effective Lagrangians constrained by the heavy quark spin symmetry and chiral symmetry, for the light quarks, we analyze the $$D^0 D^0\pi ^+,$$ D 0 D 0 π + , $$\bar{D}^0D^0\pi ^0$$ D ¯ 0 D 0 π 0 and $$D^0\bar{D}^{*0}$$ D 0 D ¯ ∗ 0 invariant mass ...
Di Guo +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Mass spectra of $$0^{--}$$ 0 - - and $$0^{+-}$$ 0 + - hidden-heavy baryoniums
European Physical Journal C: Particles and FieldsIn this work, the spectra of the prospective exotic hidden-charm and hidden-bottom baryonium, viz. the baryon–antibaryon states, with $$J^{PC}=0^{--}$$ J PC = 0 - - and $$0^{+-}$$ 0 + - are investigated in the framework of QCD sum rules.
Bing-Dong Wan
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source