Results 91 to 100 of about 1,034,135 (309)

Mapa topogràfic de Catalunya 1:250 000. 7a ed.

, 2011
1 Mapa. - Inclou 1 finestra dels voltants de Barcelona a 1:125 000 (24 x 38 cm). - Inclou la nova codificació de carreteres 2001 i toponímia .- Equidistància de les corbes de nivell: 100 m1:250 000106 x 110 cm en full de 114 x 127 cm, plegat a 25 x 14 ...
Institut Cartogràfic de Catalunya
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Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Manresa: ortofotomapa 1:5 000

, 2018
1 ortofotomapa, imprès, color. Forma part d'un projecte de cartografiar totes les capitals de comarca de la província de Barcelona. Es van fer fotografies aèries en color a escala 1:10 000 de més de 25 nuclis de la província (1974-1977). A l'any 1976 es
Diputació de Barcelona. Servei de Cartografia i Fotogrametria
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Carte de l'Afrique à l'échelle de 1:2 000 000. , Carte de l'Afrique à l'échelle du 2 000 000e : tableau d'assemblage

, 1889
Échelle(s) : 1:40 000 000Appartient à l’ensemble documentaire : R.BonapAppartient à l’ensemble documentaire : RfnEns0Appartient à l’ensemble documentaire : RfnAfn1Appartient à l’ensemble documentaire ...
France. Service géographique de l'armée. Éditeur scientifique, Régnauld de Lannoy de Bissy, Richard de (1844-1906). Cartographe   +1 more
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Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

The Effect of Map Scale on the Determination of the Coastline Length and the Area of Islands in the Adriatic Sea - the Example of the Island of Rab

Kartografija i Geoinformacije, 2006
The procedure to determine the coastline length and the area of the island of Rab from the maps at the scales 1:25 000, 1:50 000, 1:100 000, 1:200 000, 1:300 000, 1:500 000, 1:1 000 000 and 1:2 000 000 is described. The map sheets at the scales 1:25 000,
Nada Vučetić, Nedjeljko Frančula, Ivana Šimat   +2 more
doaj  

Mapa topogràfic de Catalunya 1:250 000. 5a ed.

, 2011
1 Mapa. - Equidistància de les corbes de nivell: 100 m.- Inclou 1 finestra dels voltants de Barcelona a 1:125 000 (24 x 38 cm). - Inclou la nova codificació de carreteres 20011:250 000106 x 110 cm en full de 114 x 127 cm, plegat a 25 x 14 ...
Institut Cartogràfic de Catalunya
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source