Results 31 to 40 of about 663,911 (245)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Lithuanian unpublished interwar topographical maps

Geodesy and Cartography, 2012
A number of publications about Lithuanian interwar topographical mapping present the same piece of information that until the beginning of the World War II only the following maps were published: 92 M 1:25 000 and 44 M 1:100 000. The article analyses the
Romualdas Girkus, Viktoras Lukoševičius   +1 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Об опыте разработки «Градостроительного атласа России» и современном использовании его результатов

Academia: Архитектура и строительство, 2019
В 1991-1994 годах по заданию Минстроя России «Ин­ститут геобиосферных исследований РАЕН» разрабатывал «Градостроительный атлас России» (М 1:8 000 000).
Elena Belyaeva
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Trends in chronic obstructive pulmonary disease burden and attributable death risk factors in major Belt and Road Initiative participating countries, 1990–2021

Zhongguo gonggong weisheng
ObjectiveTo understand the changing trends in the burden of chronic obstructive pulmonary disease (COPD) and the main risk factors for death in major countries participating in the Belt and Road Initiative (BRI) from 1990 to 2021, and to provide a ...
Yaning WANG, Yitong LIU, Rujian LU, Yaqin ZHONG   +3 more
doaj   +1 more source

Digitalna topografska karta 1:250 000 - prema NATO standardima / Digital 1:250 000 topographic map designed in accordance with NATO standards

Vojnotehnički Glasnik, 2007
U radu se iznose iskustva pri izradi i oblikovanju vojne topografske karte razmera 1: 250 000. Karta se izrađuje u Vojnogeografskom institutu, po NATO standardima i u digitalnom obliku.
Mirko Borisov
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The global burden of tuberculosis mortality in children: a mathematical modelling study

The Lancet Global Health, 2017
Background: Tuberculosis in children is increasingly recognised as an important component of the global tuberculosis burden, with an estimated 1 million cases in 2015.
Dr Peter J Dodd, PhD, Courtney M Yuen, PhD, Charalambos Sismanidis, PhD, James A Seddon, PhD, Helen E Jenkins, PhD   +4 more
doaj   +1 more source