Results 31 to 40 of about 10,486,500 (294)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Students' Conceptions of Scale Regarding Groundwater [PDF]
, 2007 Provides pedagogical insight concerning learners' pre-conceptions and misconceptions about groundwater The resource being annotated is: http://www.dlese.org/dds/catalog_SERC-STARTINGPOINT-000-000-000-337 ...
Lamont-Doherty Earth Observatory, Columbia University
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Demanding and Enforcing High Expectations in Freshman Courses [PDF]
, 2004 This article describes the results of an experiment in which high school graduates were enrolled in two summer science courses with extremely high goals.
Abhijit Basu, Joan Middendorf
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Adaptation: A Way of Life, Plant and Animal Desert Adaptations [PDF]
, 2003 This document provides several activities that show how desert plants and animals are well-adapted to life in the desert and thrive on little moisture and high temperatures. There are extension lessons as well as a drawing activity.
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
What similar physical processes occur on both Earth and Mars? [PDF]
, 2002 This NASA Module investigation compares and contrasts physical processes that occur on Both Earth and Mars. Students are given unidentified images of Earth and Mars.
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Systems thinking: critical thinking skills for the 1990s and beyond [PDF]
, 1993 This pdf article discusses the need for teaching systems thinking and critical thinking skills. Systems thinking and systems dynamics are important for developing effective strategies to close the gap between the interdependent nature of our problems and
Diehl E. W., Roberts N.
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
, 2003 This reference guide provides a brief review of glaciers in the Northeastern U.S. It then focuses on the glacial affects in four areas, an inland basin near the Finger Lakes area of New York, the Appalachian/Piedmont through New York and Pennsylvania ...
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