Results 61 to 70 of about 10,486,500 (294)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
, 2008 This booklet includes 31 problems that involve a variety of math skills, including scientific notation, simple algebra, and calculus. Topics covered include black holes, ice on mercury, a mathematical model of the solar interior, sunspots, the heliopause,
Sten Odenwald
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Amazing Space: Cat's Eye Nebula (NGC 6543) Lithograph [PDF]
, 2005 This lithograph features Hubble Space Telescope images and includes text that describes and explains the images. There is also an accompanying inquiry-based classroom activity entitled “In Search of the Complex Structures of Planetary Nebulae.” This ...
Bonnie Eisenhamer
core
Overcoming the Limitations of an Urban Setting Through Field-based Earth Systems Inquiry [PDF]
, 2004 Disconnection between students and nature in an urban setting thwarts student engagement and impedes geoscience teaching and learning. Conducting field trips is one way to engage students, but the urban environment does not provide an ideal setting with ...
Stuart Birnbaum
core +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A Comparison of Approaches and Instruments for Evaluating a Geological Sciences Research Experiences Program [PDF]
, 2002 This article describes a study in which changes in knowledge of science and attitudes regarding science among participants in a summer Research Experiences for Undergraduates (REU) program were examined. It was discovered that existing survey instruments
Olga Jarrett +2 more
core
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Metodología para la delimitación y caracterización de humedales en escalas 1:50 000 y 1:20 000
Tecnología y ciencias del agua, 2016 Se analiza la situación retrospectiva y actual de los humedales localizados en la zona de la Vertiente Pacífica del estado de Chiapas, México, para lo cual se aplicaron técnicas de percepción remota empleando imágenes satelitales tomadas en 1986, 2004 y ...
Jorge Brena +2 more
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