Results 121 to 130 of about 176,921 (319)

Halofuginone Disrupted Collagen Deposition via mTOR‐eIF2α‐ATF4 Axis to Enhance Chemosensitivity in Ovarian Cancer

open access: yesAdvanced Science, EarlyView.
COL1A1, a major component of ECM, contributes to chemoresistance and poor prognosis in ovarian cancer. Halofuginone (HF) attenuates CAF‐secreted COL1A1 through mTOR‐eIF2α‐ATF4 axis. Notably, HF disrupts collagen deposition to form the looser ECM and facilitates CD8+ T cell infiltration, partially via M2‐M1 macrophage polarization to enhance ...
Wenxin Li   +8 more
wiley   +1 more source

High‐Throughput Proteoform Imaging for Revealing Spatial‐Resolved Changes in Brain Tissues Associated with Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
High‐throughput proteoform imaging (HTPi) is established by combining matrix‐assisted laser desorption ionization mass spectrometry imaging and high‐sensitivity region‐specific top‐down proteomic analysis. HTPi enables the generation of annotated proteoform images with exceptional precision, high throughput, and deep coverage, showing distinct spatial ...
Yue Sun   +8 more
wiley   +1 more source

Surface‐Engineered Cenospheres Encapsulating Phase Change Materials for Functional Cementitious Composites

open access: yesAdvanced Science, EarlyView.
The global energy demand drives the need for advanced energy‐efficient building solutions. While current polymeric‐shell microencapsulated PCMs show promise for thermal energy storage, their use in cementitious materials is challenged by poor shell strength and interfacial bonding. This study develops novel cement‐compatible microencapsulated PCM using
Sahand Rahemipoor   +7 more
wiley   +1 more source

(RETRACTED ARTICLE) Effect of artificial light on plant ecology and physiology: A review

open access: yesThe Indian Journal of Agricultural Sciences, 2022
Early in the 20th century, introduction of artificial light has caused a significant change in human developmental process, but use of artificial light in night has also produced negative effect on phonological, physiological and ecological responses ...
MAMTA BAJYA   +4 more
doaj  

Enhancing the Protein Stability of an Anticancer VHH‐Fc Heavy Chain Antibody through Computational Modeling and Variant Design

open access: yesAdvanced Science, EarlyView.
In this study, a computational pipeline is developed to systematically evaluate the conformational stability, disulfide bond reduction state, and aggregation and degradation tendencies of an anticancer VHH‐Fc fusion antibody. Based on the mechanistic insights, antibody variants with enhanced stability and increased yield are successfully designed. This
Yuan Fang   +10 more
wiley   +1 more source

Ambiguity attitudes in qualitative contexts: The role of prior beliefs

open access: yesJournal of Behavioral Decision Making, Volume 36, Issue 1, January 2023., 2023
Abstract Most studies of ambiguity aversion rely on experimental paradigms involving monetary bets. Thus, the extent to which ambiguity aversion occurs outside of such contexts is much less understood, particularly when the situation cannot easily be reduced to numerical terms.
Joshua P. White, Andrew Perfors
wiley   +1 more source

Conference Highlights: Cosmic Flows [PDF]

open access: yesarXiv, 1999
I summarize the highlights of "Cosmic Flows: Towards an Understanding of the Large-scale Structure in the Universe", a workshop held in Victoria, Canada in July 1999.
arxiv  

Solution‐Processable Van Der Waals Heterojunctions on Silicon for Self‐Powered Photodetectors with High Responsivity and Detectivity

open access: yesAdvanced Science, EarlyView.
This work reports an all‐solution processable fabrication approach for fabricating Ti3C2Tx/Cu3(HHTP)2/n‐Si heterojunction as self‐powered photodetectors through the consecutive spray coating a Cu3(HHTP)2 and Ti3C2Tx thin films on n‐type silicon surface, as formed self‐supplied photodetector reveals exceptional responsivity and detectivity.
Yuansheng Ge   +5 more
wiley   +1 more source

When the poor give more than the rich: The role of resource evaluability on relative giving

open access: yesJournal of Behavioral Decision Making, Volume 36, Issue 1, January 2023., 2023
Abstract Five experiments examined the role of resource evaluability on giving. We systematically varied participants' resources they and another potential donor received and whether they could donate to a recipient either by themselves or with the other donor.
Andrea Pittarello   +3 more
wiley   +1 more source

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