Results 211 to 220 of about 1,579,719 (306)

Platform Assessment of Concentration-QTc Relationship Across GalNAc-siRNA Molecules. [PDF]

open access: yesClin Pharmacokinet
Badri P   +6 more
europepmc   +1 more source

Intracranial electroencephalographic connectivity analysis to localize epileptogenic networks: Systematic review and meta‐analysis from ILAE Epilepsy Surgery Networks Task Force

open access: yesEpilepsia, EarlyView.
Abstract Intracranial electroencephalographic (iEEG) connectivity analysis is a promising method to localize epileptic networks and guide surgical planning in focal drug‐resistant epilepsy. Despite numerous studies exploring its utility, the added value of iEEG connectivity over standard clinical presurgical evaluation remains unclear.
Nishant Sinha   +15 more
wiley   +1 more source

Long‐term safety of early discontinuation of antiseizure medication after resolution of acute provoked neonatal seizures

open access: yesEpilepsia, EarlyView.
Abstract Objective To assess long‐term safety of antiseizure medication (ASM) discontinuation after resolution of acute provoked neonatal seizures and prior to hospital discharge. Methods Prospective, observational, comparative effectiveness cohort study of neonates with acute provoked seizures born from July 2015 to March 2018, and followed until ...
Hannah C. Glass   +16 more
wiley   +1 more source

Mortality in functional seizures: Evidence from a large electronic health records dataset

open access: yesEpilepsia, EarlyView.
Abstract Objective Several studies have found that people with functional seizures (FS) have increased mortality, approaching that of epilepsy (epileptic seizures [ES]). The small numbers of deaths in these studies make it unclear whether they can be attributed to comorbidities. We used a very large electronic health database to compare mortality in FS
Richard A. Kanaan   +4 more
wiley   +1 more source

Sodium‐glucose cotransporter 2 inhibitors and the risk of late onset epilepsy: A real‐world cohort study

open access: yesEpilepsia, EarlyView.
Abstract Objective Late onset epilepsy (LOE) is associated with substantial morbidity. Sodium‐glucose cotransporter 2 inhibitors (SGLT2i) may exert neuroprotective effects. This study evaluated the association between SGLT2i and risk of LOE among older adults with type 2 diabetes mellitus.
Bing‐Hua Lin   +3 more
wiley   +1 more source

Stereo‐EEG mapping of visual working memory with task‐related high‐gamma modulations

open access: yesEpilepsia, EarlyView.
Abstract Objective We describe a safe, informative, and easy‐to‐implement approach for presurgical mapping of visual working memory (VWM) with stereo‐electroencephalography (SEEG). Methods Twenty‐four patients with drug‐resistant epilepsy, 11–23 years of age, performed a single‐probe change detection VWM task, during SEEG monitoring.
Brian Ervin   +13 more
wiley   +1 more source

Isoflurane aggravates pre-existing proteotoxicity in adult nematodes by suppressing mitochondrial fitness. [PDF]

open access: yesSci Rep
Elami T   +7 more
europepmc   +1 more source

Mental health of children with epilepsy in Ukraine during the war

open access: yesEpilepsia, EarlyView.
Abstract Objective The ongoing conflict in Ukraine has created a severe humanitarian crisis, disproportionately affecting vulnerable populations such as children with chronic conditions. We set out to determine information about mental health in children with epilepsy in Ukraine affected by the conflict.
Volodymyr Kharytonov   +4 more
wiley   +1 more source

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