Results 101 to 110 of about 306,283 (398)

GX15-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy [PDF]

Glucocorticoids (GCs) are common components of many chemotherapeutic regimens for lymphoid malignancies including acute lymphoblastic leukemia (ALL). The BCL-2 family has an essential role in regulating GC-induced cell death.
A Holleman, A Kihara, AA Rambal, AD Schimmer, AP Martin, B Levine, C Campas, C Ploner, C Ploner, CC Jiang, CW Distelhorst, E Laane, E Wirawan, G Wei, J Lu, JE Chipuk, JT Opferman, L Bonapace, LM High, M Konopleva, M Nguyen, M Vogler, MH Kang, N Mizushima, O Frankfurt, PS Bachmann, RJ Youle, RW Stam, S Erlich, S Schmidt, S Sinha, S Trudel, SL Planey, SM O’Brien, SN Willis, TN Chonghaile, WJ Tissing, WJ Tissing   +37 more
core   +2 more sources

Acceptance test report for the L-070 project [PDF]

, 1996
This document contains the acceptance test report for the mechanical equipment and instrumentation installed per the L-070 project. The systems that were tested were the pump controls for the 3906 Lift Station and the 350-A Lift Station. The verification of an alarm signal installed between the 3906 lift station and the 340 Facility (3707F Bldg.) was ...
openaire   +3 more sources

Engineered Genetic Circuits Activated by Bezafibrate Improve ESC‐Based TAA Cancer Vaccine Efficacy and PD‐L1 Nanobody Therapy

Advanced Science, EarlyView.
Synthetic gene circuits regulated by bezafibrate are developed to express tumor antigens and PD‐L1 nanobody (PD‐L1nb), enhancing cancer immunotherapy. Delivered via HEK293T cells, ESCs, or directly injected the plasmids containing the circuit into the tumor, the circuits reduce tumor growth, boost CD8+ T cells, and minimize T cell exhaustion.
Meiling Jin, Shuzhen Liu, Mingshuo Zhan, Jian‐Dong Huang   +3 more
wiley   +1 more source

Holomorphic Distributions and Connectivity by Integral Curves of Distributions [PDF]

SIGMA 15 (2019), 070, 6 pages, 2019
It is known that the classical Frobenius theorem on conditions of integrability for distributions of planes can be extended to the case of complex holomorphic distributions. We show that an alternative criterion for integrability, namely, non-connectivity, discovered (or at least, marked and explicitly formulated) by Carath\'eodory in relation to ...
arxiv   +1 more source

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

Potential and Limitations of Induced Pluripotent Stem Cells-Derived Mesenchymal Stem Cells in Musculoskeletal Disorders Treatment

Biomolecules, 2023
The burden of musculoskeletal disorders (MSK) is increasing worldwide. It affects millions of people worldwide, decreases their quality of life, and can cause mortality. The treatment of such conditions is challenging and often requires surgery. Thus, it
Isabelle Xavier Dias, Aline Cordeiro, João Antonio Matheus Guimarães, Karina Ribeiro Silva   +3 more
doaj   +1 more source

Relativistic X-Ray Jets from the Black Hole X-Ray Binary MAXI J1820+070 [PDF]

Astrophysical Journal, 2020
The black hole MAXI J1820+070 was discovered during its 2018 outburst and was extensively monitored across the electromagnetic spectrum. Following the detection of relativistic radio jets, we obtained four Chandra X-ray observations taken between 2018 ...
M. Espinasse, S. Corbel, P. Kaaret, E. Tremou, G. Migliori, R. Plotkin, J. Bright, J. Tomsick, A. Tzioumis, R. Fender, J. Orosz, E. Gallo, J. Homan, P. Jonker, J. Miller-Jones, D. Russell, S. Motta   +16 more
semanticscholar   +1 more source

Al‐Doped LaTiO2N Prepared via Flame Spray Pyrolysis for Photocatalytic Hydrogen Evolution

Advanced Energy and Sustainability Research, EarlyView.
Flame spray pyrolysis enables the synthesis of La–Ti oxides with a simple perovskite‐type structure, and Al doping promotes the formation of the simple perovskite‐type La–Ti oxides. The Al‐doped LaTiO2N obtained by nitridation has a reduced defect concentration due to suppressed structural change, which contributes to the improvement of hydrogen ...
Mayu Inose, Shuhei Nakakura, Takashi Hisatomi, Tsuyoshi Takata, Kazunari Domen   +4 more
wiley   +1 more source

Racism, Ethnicity and the Media in Africa: Reflections Inspired by Studies of Xenophobia in Cameroon and South Africa Rassismus, Ethnizität und die Medien in Afrika: Reflektionen angeregt durch Studien zu Fremdenfeindlichkeit in Kamerun und Südafrika

Africa Spectrum, 2010
This paper demonstrates the extent to which the media and belonging in Africa are torn between competing and often conflicting claims of bounded and flexible ideas of culture and identity.
Francis B. Nyamnjoh
doaj  

Next-Generation Dental Materials: Exploring Bacterial Biofilm Formation on 3D-Printable Resin-Based Composites

Journal of Functional Biomaterials
This study evaluated the microbial growth profile of subgingival multispecies biofilm on 3D-printable resin-based composites (PRBCs). A 96-well cell plate cultivated a 39-species biofilm associated with periodontitis over 7 days.
Emerson Koji Uehara, Gustavo Castro de Lima, Janaina de Cassia Orlandi Sardi, Luciene Cristina de Figueiredo, Jamil Awad Shibli, Thabet Asbi, Doron Haim, José Augusto Rodrigues   +7 more
doaj   +1 more source