Results 91 to 100 of about 45,356 (184)

Synthesis of 3-(Alkylamino)-, 3-(Alkoxy)-, 3-(Aryloxy)-, 3-(Alkylthio)-, and 3-(Arylthio)-1,2,4-triazines by Using a Unified Route with 3-(Methylsulfonyl)-1,2,4-triazine

, 2016
In our attempts to synthesize 3‐(alkylthio)‐ and 3‐(alkoxy)‐1,2,4‐triazines without substituents at the 5‐ or 6‐position, the synthesis of their anticipated precursor 3‐(methylsulfonyl)‐1,2,4 triazine was also optimized.
Gable, RW, Shi, DH, Harjani, JR, Baell, JB   +3 more
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3,3 '-Disubstituted 5,5 '-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity

, 2019
A series of 3,3′-disubstituted 5,5′-bi(1,2,4-triazine) derivatives was synthesized and screened against the erythrocytic stage of Plasmodium falciparum 3D7 line. The most potent dimer, 6k, with an IC50 (50% inhibitory concentration) of 0.008 μM, had high
Cuellar, Matthew E, Wirjanata, Grennady, Walters, Michael A, Fletcher, Sabine, Ban, Kung, Ellis, Katherine, Dingjan, Tamir, Duffy, Sandra, Creek, Darren, Shi, Da-Hua, Lucantoni, Leonardo, Harjani, Jitendra R, Teguh, Silvia, Noviyanti, Rintis, Chiu, Francis CK, Diab, Sarah, Baell, Jonathan B, Beveridge, Julia G, Charman, Susan A, Huang, Fei, Xue, Lian, Edstein, Michael D, Marfurt, Jutta, Avery, Vicky M, Blundell, Scott, Strasser, Jessica M, Ralph, Stuart A, Price, Ric N, Chavchich, Marina, Dahlin, Jayme L   +29 more
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Synthesis of 6-(2-Methoxynaphthyl)-2,3-dihydro-1,2,4-triazine-3-thione as a New Reagent for Spectrophotometric Determination of Copper

International Journal of Analytical Chemistry, 2014
A simple, sensitive, accurate, and green spectrophotometric method for the determination of Cu(II) using newly synthesized reagent, 6-(2-methoxynaphthyl)-2,3-dihydro-1,2,4-triazine-3-thione (MNDTT), has been developed.
Maliheh Barazandeh Tehrani, Hutan Ghanbari, Effat Souri, Fazel Shamsa, Mohsen Amini   +4 more
doaj   +1 more source

7-Dimethylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine methanol solvatePart 11 in the series `Fused heterocyclic systems with an s-triazine ring'. For Part 10, see Dolzhenko et al. (2008).

Acta Crystallographica Section E, 2008
7-Dimethylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine crystallized with one molecule of methanol to give the title compound, C12H13N7·CH3OH.
Wai Keung Chui, Su Fen Woo, Lip Lin Koh, Geok Kheng Tan, Anton V. Dolzhenko   +4 more
doaj   +1 more source

Synthesis of 3-allylthio-5-оxo-1,2,4-triazine-6-carboxylic and 2-allyl-5-аmino-1,2,4-triazine-6-carboxylic acids

, 2013
Рыбакова Анастасия Владимировна – преподаватель, соискатель кафедры органической химии, химический факультет, Южно-Уральский государственный университет. 454080, г. Челябинск, пр. им. В.И. Ленина, 76. E-mail: zhurav666@rambler.ru Ким Дмитрий Гымнанович –
Slepukhin, P. A., Рыбакова, А. В., Rybakova, A. V., Слепухин, П. А., Чарушин, В. Н., Ким, Д. Г., Kim, D. G., Charushin, V. N.   +7 more
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1,2,4-Triazine N-oxide derivatives: Studies as potential hypoxic cytotoxins. Part III

, 2004
New 5-(2-arylethenyl)-1,2,4-triazine N-oxide and N,N'-dioxide derivatives were synthesized in order to obtain compounds as selective hypoxic cell cytotoxins.
Antonio Monge, Monge, A., Mercedes González, Saenz Mendez, Patricia,, Olea Azar, Claudio, Saenza, P., Saenz, P., Risso, Mariela, Amaia Azqueta, Azqueta, Amaia, Olea-Azar, Claudio,, Ana M. Bruno, Cerecetto, Hugo, González, M., Bruno, Ana M,, Claudio Olea‐Azar, De Ceráin, Adela López,, González, Mercedes,, Cerecetto, Hugo,, Monge, Antonio,, Bruno, A. M., De Cerain, A. L., Patricia Saenz, Adela López de Ceráin, Azqueta, Amaia,, Hugo Cerecetto, Mariela Risso, Risso, Mariela,   +27 more
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Synthesis of 6-(Phenanthrene-3-yl)-2,3-dihydro-1,2,4,-triazine-3-thione as a New Reagent for the Non-Extractive Spectrophotometric Determination of Cu(II) [PDF]

Iranian Journal of Chemistry & Chemical Engineering, 2018
A simple, sensitive, and non-extractive spectrophotometric method was developed for the determination of copper (II) using a newly synthesized chromogenic reagent, 6-(phenanthrene-3-yl)-1,2,4,-triazine-3-thione(PhDTT), in Tween 80 neutral surfactant.
Marzieh Maskoot, Maliheh Barazandeh Tehrani, Mahdyeh Asaee, Effat Souri   +3 more
doaj  

Synthesis and Structure-Activity Relationship of Some New Thiophene-Based Heterocycles as Potential Antimicrobial Agents

Molecules, 2016
Several new pyrazole, pyridine, [1,2,4]triazolo[1,5-α]pyrimidine, benzimidazo[1,2-a]pyrimidine and 1,2,4-triazolo[3,4-c][1,2,4]triazine derivatives incorporating a thiophene moiety were synthesized from (E)-ethyl 5-(3-(dimethylamino)acryloyl)-4-phenyl-2-(
Yahia Nasser Mabkhot, Fatima Alatibi, Nahed Nasser E. El-Sayed, Nabila Abdelshafy Kheder, Salim S. Al-Showiman   +4 more
doaj   +1 more source

Sequential Michael Addition and Enamine-Promoted Inverse Electron Demanding Diels–Alder Reaction upon 3-Vinyl-1,2,4-triazine Platforms

, 2015
International audienceAn original one-pot Michael addition-ihDA/rDA sequence was achieved from 3-vinyl-1,2,4-triazine platforms used as unprecedented Michael acceptors.
Guillaumet, Gerald, Brière, Jean-François, Suzenet, Franck, Lorion, Magali   +3 more
core   +1 more source

Potential of Triazines as Antidiabetic Agents—A Review of Structures and Pharmacological Activity

Pharmaceuticals
Type 2 diabetes (T2D), a major global health challenge, represents approximately 96% of all cases of diabetes worldwide. Epidemiological forecasts indicate the prevalence of this disease could rise by almost 45% over the next 25 years.
Dorota Łażewska, Diana Strelchuk, Jadwiga Handzlik   +2 more
doaj   +1 more source