Results 101 to 110 of about 51,319 (173)

3-Cyano-4-Hydroxy-1,4-Dihydro-[1,2,4]Triazolo[5,1-C][1,2,4]Triazine, Compound with Anti-Glycating and Anti-Glycoxidation Activities

, 2022
Изобретение относится к области органической химии, а именно к 3-циано-4-гидрокси-[1,2,4]триазоло[5,1-с][1,2,4]триазину формулы 1, который обладающей антигликирующей и антигликоксидационной активностями. Технический результат: обеспечение антигликирующей
Chupakhin, O. N., Чупахин, О. Н., Litvinov, R. A., Yakovlev, D. S., Спасов, А. А., Русинов, В. Л., Султанова, К. Т., Литвинов, Р. А., Sultanova, K. T., Дрокин, Р. А., Drokin, R. A., Spasov, A. A., Rusinov, V. L., Воинков, Е. К., Voinkov, E. K., Чарушин, В. Н., Яковлев, Д. С., Гасайниева, А. Г., Charushin, V. N., Gasajnieva, A. G.   +19 more
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1,2,4-Triazine Derivatives as NLRP3 Inhibitors for Treating Diseases. [PDF]

ACS Med Chem Lett, 2023
Sabnis RW.
europepmc   +1 more source

Molecular modeling studies of 1,2,4-triazine derivatives as novel h-DAAO inhibitors by 3D-QSAR, docking and dynamics simulations

, 2018
Computational modeling methods were successfully applied to discover new 1,2,4-triazine compounds as potential h-DAAO inhibitors.
Shuai Wang, Yu Jie Ren, Kai Rui Feng, Qian, Ping Ping, Feng, Kai Rui, Wang, Shuai, Ren, Yu Jie, Ping Ping Qian   +7 more
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Determination of pKa of triazolo[5,1-c][1,2,4]triazines in non-aqueous media by potentiometric titration

Chimica Techno Acta
In this work, for the first time, an approach was suggested for determining the pKa of triazolo[5,1-c][1,2,4]triazine compounds in N,N-dimethylformamide using potentiometric titration.
Alexandra V. Ivoilova, Polina N. Mozharovskaia, Liya V. Mokrousova, Ivan A. Balin, Anton N. Tsmokalyuk, Roman A. Drokin, Irina M. Sapozhnikova, Vladimir L. Rusinov, Alla V. Ivanova, Alisa N. Kozitsina   +9 more
doaj   +1 more source

Synthesis and Characterization Antifungal Fluorine Substituted Fused Heterobicyclic Nitrogen Systems Containing 1,2,4-triazine Moiety

, 2018
Synthesis of some new full fluorinated heterobicyclic nitrogen systems containing 1,2,4-triazine moiety (4-10) have been deduced from heterocyclization of 6-(2'-trifluoroacetylamino)phenyl-3-(4'-fluorophenyl-1,2,4-triazin-5-one (3) with active oxo / halo-
Ola Ahmad Abu Ali
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SYNTHESIS OF OXAZOLO [3, 2-b] 1, 2, 4- TRIAZINES A NOVEL HETEROCYCLIC SYSTEM [PDF]

Journal of Sciences, Islamic Republic of Iran, 1990
The synthesis of 6- methyl- 2- phenyl- 7H- oxazolo [3,2-b] 1,2,4-Triazine- 7-one (6, R=Ph) and its 2-P- bromophenyl analogue to the two members of a new heterocyclic system is ...
doaj  

Visible-Light-Induced Oxyalkylation of 1,2,4-Triazine-3,5(2H, 4H)‑diones with Ethers via Oxidative Cross-Dehydrogenative Coupling

An efficient and convenient method to synthesize 6-oxyalkylated 1,2,4-triazine-3,5­(2H, 4H)-diones has been developed via visible-light-induced cross-dehydrogenative coupling reaction between 1,2,4-triazine-3,5­(2H, 4H)-diones and ethers with a wide ...
Jiquan Zhao (4432000), Yushi Tan (11993294), Ya-Ping Han (1413178), Wu Xuekun (12907693), Yuecheng Zhang (4432003), Hong-Yu Zhang (47329)   +5 more
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Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain. [PDF]

Med Chem Res, 2023
Dzierba CD, Dasgupta B, Karageorge G, Kostich W, Hamman B, Allen J, Esposito KM, Padmanabha R, Grace J, Lentz K, Morrison J, Morgan D, Easton A, Bourin C, Browning MR, Rajamani R, Good A, Parker DD, Muckelbauer JK, Khan J, Camac D, Ghosh K, Halan V, Lippy JS, Santone KS, Denton RR, Westphal R, Bristow LJ, Conway CM, Bronson JJ, Macor JE.   +30 more
europepmc   +1 more source

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir. [PDF]

Org Process Res Dev, 2022
Roy S, Yadaw A, Roy S, Sirasani G, Gangu A, Brown JD, Armstrong JD, Stringham RW, Gupton BF, Senanayake CH, Snead DR.   +10 more
europepmc   +1 more source

3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity

, 2010
We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells.
Ryan, Eileen, Baell, Jonathan B, Oliver Montagnat, Hughes, Andrew, Katneni, Kasiram, Eileen Ryan, Ban, Kung, Sandra Duffy, Yelena Khakham, Kasiram Katneni, Avery, Vicky M, Duffy, Sandra, Kung Ban, Vicky M. Avery, Jonathan B. Baell, Andrew Hughes, Khakham, Yelena, Montagnat, Oliver   +17 more
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