Results 121 to 130 of about 45,356 (184)

Synthesis and Anti-Inflammatory Evaluation of 3-Methylthio-1,2,4-Triazines, 3-Alkoxy-1,2,4-Triazines, and 3-Aryloxy-1,2,4-Triazines

Journal of Pharmaceutical Sciences, 1980
To develop nonacidic, nonsteroidal anti-inflammatory agents without GI complications, a series of asymmetric triazines was synthesized and evaluated for anti-inflammatory efficacy in the carrageenan-induced pedal edema assay. Toxicity was estimated by determination of approximate LD50 values in mice.
W P, Heilman, R D, Heilman, J A, Scozzie, R J, Wayner, J M, Gullo, Z S, Ariyan   +5 more
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ChemInform Abstract: 1,2,4‐TRIAZINES PART 10, DIMERIZATIONS OF 1,2,4‐TRIAZINES

Chemischer Informationsdienst, 1973
AbstractAus den 1,2,4‐Triazinen (I) mit freier 5‐Stellung erhält man in der angegebenen Weise bei der Behandlung mit Methylat oder mit Kaliumcyanid über anionische Zwischenstufen Dimere wie (II).
D. K. KRASS, T.‐K. CHEN, W. W. PAUDLER
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1,2,4-Triazine

2001
[290-38-0] C3H3N3 (MW 81.09) InChI = 1S/C3H3N3/c1-2-5-6-3-4-1/h1-3H InChIKey = FYADHXFMURLYQI-UHFFFAOYSA-N (electron-deficient heteroaromatic azadiene capable of participation in inverse electron demand Diels–Alder reactions with electron-rich dienophiles1) Alternate Names: as-triazine; α-triazine; isotriazine ...
Dale L. Boger, Minsheng Zhang
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Chemistry of 1,2,4‐triazines, XV. First metalation of 1,2,4‐triazine derivatives

Liebigs Annalen der Chemie, 1993
Abstract5‐Methoxy‐1,2,4‐triazines 2 were lithiated with lithium 2,2,6,6‐tetramethylpiperidide and the formed 6‐lithio‐5‐methoxy‐1,2,4‐triazines 4 trapped with aldehydes or iodine.
Nelly Plé, Alain Turck, Guy Quéguiner, Bernd Glassl, Hans Neunhoeffer   +4 more
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Synthesis of 1,2,4-Triazines; XIII. Regioselective Synthesis of Trialkyl-1,2,4-triazines

HETEROCYCLES, 1992
Trialkyl-1,2,4-triazines (3) were prepared by heating α-oxoacylhydrazones (4) or N,N-dimethylaminomethylene hydrazones (19) with ammonium acetate at 100°C.
Hans Neunhoeffer, Tadashi Ohsumi
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1,2,4‐triazines. III. A convenient synthesis of 1,2,4‐triazines and their covalent hydration

Journal of Heterocyclic Chemistry, 1970
AbstractA general synthesis of 1,2,4‐triazines, from 3‐methylthiotriazines is described. It has been shown that 1,2,4‐triazines undergo covalent hydration across the N4‐C5 bond.
William W. Paudler, Teh‐Kuei Chen
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ChemInform Abstract: 1,2,4‐Triazine. Part 4. Conversion of 1,2,4‐Triazine N4‐Oxides to Chloro‐ and Chloromethyl‐1,2,4‐triazines with POCl3.

ChemInform, 1993
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
J. K. LEE, H. C. KWON, H. G. KIM
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1,2,4-Triazines Are Versatile Bioorthogonal Reagents

Journal of the American Chemical Society, 2015
A new class of bioorthogonal reagents, 1,2,4-triazines, is described. These scaffolds are stable in biological media and capable of robust reactivity with trans-cyclooctene (TCO). The enhanced stability of the triazine scaffold enabled its direct use in recombinant protein production.
David N, Kamber, Yong, Liang, Robert J, Blizzard, Fang, Liu, Ryan A, Mehl, K N, Houk, Jennifer A, Prescher   +6 more
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1,2,4-triazines and condensed derivatives—XIV

Tetrahedron, 1974
Abstract 3 - Alkylthio - 6,7 - dihydro - [1.2.4]triazino - [1.6-c]quinazolin - 5 - ium - 1 - olates (3), prepared by condensation of 3 - alkylthio -6-(2- aminophenyl) - 1,2,4 - triazin - 5(2H) - ones (1) with aldehydes, ketones or their equivalents are transformed by thermolysis and/or acid treatment into 3 - alkylthio - [1.2.4]triazino[5.6-b]indoles
G. Doleschall, K. Lempert
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Reaction of 1,2,4-triazines with nitronate anions, direct nucleophilic acylation of 1,2,4-triazines.

Tetrahedron Letters, 1984
Abstract Nitronate anions replace 5-hydrogen atom in a variety of 3-substituted 1,2,4-triazine derivatives giving oximes of 5-formyl and 5-acyl 1,2,4-triazines.
A. Rykowski, M. Mąkosza
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