Results 1 to 10 of about 8,177 (163)

Metal-free [2 + 1 + 3] Cycloaddition of Trifluoroacetaldehyde NSulfonylhydrazones with Hexahydro-1,3,5-triazines Leading to Trifluoromethylated 2,3,4,5-Tetrahydro-1,2,4-triazines

, 2022
A transition-metal-free [2 + 1 + 3] cycloaddition of trifluoroacetaldehyde N-sulfonylhydrazone and hexahydro-1,3,5-triazine was described. This operationally simple protocol provides a general synthesis of diverse trifluoromethylated 2,3,4,5-tetrahydro-1,
Qihao Jin, Zhongxue Fang, Zhongxue Fang (1651942), Yongquan Ning, Yongquan Ning (1608853), Xinyu Wang (341591), Xinyu Wang, Qihao Jin (11878717)   +7 more
core   +1 more source

Visible-Light-Catalyzed [3 + 1 + 2] Coupling Annulations for the Synthesis of Unsymmetrical Trisubstituted Amino-1,3,5-triazines

, 2019
A visible-light catalyzed [3 + 1 + 2] annulation for the synthesis of unsymmetrical trisubstituted amino-1,3,5-triazines from amidines, isothiocyanates, and 1,1,3,3-tetramethylguanidines has been developed.
Chengtang Du (2150830), Lvyin Zheng (4794129), Liuhuan Cai (6470858), Wei Guo (86150), Zhen Xie (519905), Liping Chen (119540), Luo Li (2126968), Xiaolin Fan (1605136), Kai Zhang (102844), Kailiang Tao (4794126), Mingming Zhao (760369), Wen Tan (102776)   +11 more
core   +3 more sources

Dienophilicity of Imidazole in Inverse Electron Demand Diels−Alder Reactions. 4. Intermolecular Reactions with 1,2,4-Triazines

, 2016
Intermolecular inverse electron demand cycloadditions of 2-substituted imidazoles with various 1,2,4-triazines produced both imidazo[4,5-c]pyridines (3-deazapurines) and pyrido[3,2-d]pyrimid-4-ones (8-deazapteridines).
Zhao-Kui Wan (2004907), Brian R. Lahue (1427578), John K. Snyder (331112)   +2 more
core   +2 more sources

Dearomative [4 + 2] Annulation of Electron-Poor N‑Heteroarenes with Azoalkenes for Access to Polycyclic Tetrahydro-1,2,4-triazines

, 2023
A direct dearomative [4 + 2] annulation of electron-poor N-heteroarenes with azoalkenes generated in situ from α-halogeno hydrazones was developed under mild conditions.
Yu-Qing Guan, Dong-Chao Wang (1863811), Hai-Ming Guo (1395550), Jia-Hui Liu (1841488), Jia-Hui Liu, Yu-Qing Guan (5810885), Dong-Chao Wang, Hai-Ming Guo   +7 more
core   +1 more source

A Regioselective Approach to 5-Substituted-3-amino-1,2,4-triazines

, 2016
Nucleophilic displacement of readily available α,α-dibromoketones with excess morpholine gave the corresponding ketoaminals, which upon condensation with aminoguanidine in MeOH in the presence of AcOH afforded 5-substituted-3-amino-1,2,4-triazines in >95%
Paul N. Devine (1831207), Robert A. Reamer (1433476), John Limanto (1433470), Richard A. Desmond (2454514), Donald R. Gauthier (1633033), R. P. Volante (2664142)   +5 more
core   +1 more source

One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N‑Tosylhydrazones: Access to 1,2,4-Triazines

, 2017
A new, three-step, telescoped reaction sequence for the regioselective conversion of N-tosyl hydrazones and aziridines to 3,6-disubstituted and 3,5,6-trisubstituted 1,2,4-triazines is described. The process involves an efficient nucleophilic ring opening
Lorène Crespin (3748822), David C. Blakemore (465247), Lorenzo Biancalana (2572165), Tobias Morack (3748825), Steven V. Ley (532034)   +4 more
core   +1 more source

Solvent-Directed Click Reaction between Active Methylene Compounds and Azido-1,3,5-triazines

, 2019
A novel solvent-directed click reaction between active methylene compounds and azido-1,3,5-triazines has been developed. In aqueous solution, the regiospecific trisubstituted 1,2,3-triazole products are quickly synthesized in high yields under mild ...
Mingming Ma, Mingming Ma (584228), Yuanheng Li (342955), Ziqiang Yan (332514), Ziqiang Yan, Yuanheng Li   +5 more
core   +1 more source

Unexpected O–H Insertion of Rhodium-Azavinylcarbenes with N‑Acylhydrazones: Divergent Synthesis of 3,6-Disubstituted- and 3,5,6-Trisubstituted-1,2,4-Triazines

, 2017
A practical and efficient method for divergent synthesis of 3,6-disubstituted- and 3,5,6-trisubstituted-1,2,4-triazines via unexpected rhodium-catalyzed O–H insertion/rearrangement/conditions-controlled intramolecular cyclization and oxidation reaction ...
Shiwei Zhang (2394778), Peiwen Pan (366415), Jiang Meng (1754266), Min Wen (3549752), Xingxin Yu (1392106), Wei-Ping Deng (1392103)   +5 more
core   +1 more source

Non-Peptide Corticotropin-Releasing Hormone Antagonists:  Syntheses and Structure−Activity Relationships of 2-Anilinopyrimidines and -triazines

, 2016
Screening of our chemical library using a rat corticotropin-releasing hormone (CRH) receptor assay led to the discovery that 2-anilinopyrimidine 15-1 weakly displaced [125I]-0-Tyr-oCRH from rat frontal cortex homogenates when compared to the known ...
Paul J. Krenitsky (2001346), Helen L. Shen (3022248), Shiew-Mei Huang (2925420), Joseph P. Rescinito (3022245), Robert S. Cheeseman (3022296), Lawrence Fitzgerald (2375194), Argyrios G. Arvanitis (2361442), Anthony J. Cocuzza (3022278), Dennis Chidester (3022257), Andrea Hollis (3022263), Y. Nancy Wong (3022269), Matthew Curry (2941455), Paul J. Gilligan (1601827), Everett Scholfield (3022281), Errol B. De Souza (3018537), Charles Arnold (3022242), Rajagopal Bakthavatchalam (2304055), Thomas E. Christos (3007227), Frank W. Hobbs (2361430), James P. Beck (3022275), Steven Culp (3022251), John Klaczkiewicz (3022272), Dimitri Grigoriadis (3022260), S. William Tam (2719417), Liqi He (2375200), Robert J. Chorvat (3022299), Richard G. Wilde (1849003)   +26 more
core   +1 more source

Preparation of hollow porous molecularly imprinted polymers and their applications to solid-phase extraction of triazines in soil samples

, 2011
Porous polymers have aroused increasing interest due to their controllable hole(s) structure in favor of mass transfer. In this work, three types of porous molecularly imprinted polymers (MIPs) using atrazine as template, namely single-hole hollow ...
Lingxin Chen, Jiping Ma, Xu, Shoufang, Chen, Lingxin, Li, Jinhua, Ma, Jiping, Shoufang Xu, Jinhua Li, Wei Qin, Qin, Wei   +9 more
core   +1 more source