Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity [PDF]
Pharmaceuticals, 2023 A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra +11 more
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Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives [PDF]
Molecules, 2020 This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e ...
Zofia Bernat +4 more
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A theoretical study on the corrosion inhibition of Cu surfaces using 4-amino-3-thioxo-6-methyl-1,2,4-triazine-5-one and its derivatives [PDF]
Scientific ReportsThe current study focused on evaluating the behavior of 4-amino-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2 H)-one (1a) along with its tautomers, as well as 4-amino-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2 H)-one (2a) and its tautomers as potential ...
Zahra Jafarzadegan +3 more
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Evaluation of Multidentate Ligands Derived from Ethyl 1,2,4‐triazine‐3‐carboxylate Building Blocks as Potential An(III)‐Selective Extractants for Nuclear Reprocessing [PDF]
ChemistryOpenBis‐1,2,4‐triazine ligands are amongst the most promising soft N‐donor ligands for the partitioning of trivalent actinides from trivalent lanthanides; a key separation proposed in the future reprocessing of spent nuclear fuels.
Andrey V. Zaytsev +6 more
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Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in men and in women. The impact of the new pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide (MM-129) was evaluated against human colon cancer in vitro and in zebrafish
Justyna Magdalena Hermanowicz +12 more
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The activity of pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryIn the last decade, an increasing interest in compounds containing pyrazolo[4,3-e][1,2,4]triazine moiety is observed. Therefore, the aim of the research was to synthesise a novel sulphonyl pyrazolo[4,3-e][1,2,4]triazines (2a, 2b) and pyrazolo[4,3-e ...
Anna Szymanowska +6 more
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Synthesis, Characterization, and Biological Evaluation of Novel 7-Oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic Acid Derivatives [PDF]
Molecules, 2020 A series of novel 7-oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic acid derivatives was synthesized in good yields by a multi-step procedure that included the generation of the S-alkylated derivatives from 6-substituted arylmethyl-3-mercapto-1,2,4 ...
Dong Cai +7 more
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Energetic salt of guanidinium 3,7-Bis(dinitromethylene)-octahydro-[1,2,4]-triazino-[6,5-e][1,2,4]triazine and its crystal structure [PDF]
ITM Web of Conferences, 2022 Energetic salt of guanidinium 3,7-Bis(dinitromethylene)-octahydro-[1,2,4]-triazino-[6,5-e][1,2,4]triazine(1) was prepared through the reaction of 3,7-Bis(dinitromethylene)-octahydro-[1,2,4]-triazino-[6,5-e][1,2,4]triazine with guanidinium carbonate.
Zhou Yifei, Gao Haixiang
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Revisiting the Synthesis of Functionally Substituted 1,4-Dihydrobenzo[e][1,2,4]triazines
Molecules, 2022 A series of novel 1,4-dihydrobenzo[1,2,4][e]triazines bearing an acetyl or ester moiety as a functional group at the C(3) atom of the 1,2,4-triazine ring were synthesized.
Margarita A. Epishina +2 more
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Beilstein Journal of Organic Chemistry, 2021 Two series of functionalized imidazothiazolotriazine derivatives were synthesized via the condensation of imidazo[4,5-e]-1,2,4-triazine-3-thiones with acetylenedicarboxylic acid dimethyl and diethyl esters (DMAD and DEAD) and subsequent base-catalyzed ...
Alexei N. Izmest’ev +4 more
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