Results 1 to 10 of about 51,319 (173)

A theoretical study on the corrosion inhibition of Cu surfaces using 4-amino-3-thioxo-6-methyl-1,2,4-triazine-5-one and its derivatives [PDF]

Scientific Reports
The current study focused on evaluating the behavior of 4-amino-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2 H)-one (1a) along with its tautomers, as well as 4-amino-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2 H)-one (2a) and its tautomers as potential ...
Zahra Jafarzadegan, Alireza Najafi Chermahini, Hossein Farrokhpour, Majid Mir Mohammad Sadeghi   +3 more
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Energetic salt of guanidinium 3,7-Bis(dinitromethylene)-octahydro-[1,2,4]-triazino-[6,5-e][1,2,4]triazine and its crystal structure [PDF]

ITM Web of Conferences, 2022
Energetic salt of guanidinium 3,7-Bis(dinitromethylene)-octahydro-[1,2,4]-triazino-[6,5-e][1,2,4]triazine(1) was prepared through the reaction of 3,7-Bis(dinitromethylene)-octahydro-[1,2,4]-triazino-[6,5-e][1,2,4]triazine with guanidinium carbonate.
Zhou Yifei, Gao Haixiang
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Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity [PDF]

Pharmaceuticals, 2023
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra, Ainur D. Sharapov, Ramil F. Fatykhov, Anastasya P. Potapova, Igor A. Khalymbadzha, Maria I. Valieva, Dmitry S. Kopchuk, Grigory V. Zyryanov, Alexander S. Bunev, Vsevolod V. Melekhin, Vasiliy S. Gaviko, Andrey A. Zonov   +11 more
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Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives [PDF]

Molecules, 2020
This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e ...
Zofia Bernat, Anna Szymanowska, Mateusz Kciuk, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +4 more
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Targeting colorectal cancer with pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides: comprehensive in vitro evaluation [PDF]

Scientific Reports
Colorectal cancer (CRC) remains a major global health challenge, ranking as the third most common malignancy and the second leading cause of cancer-related mortality worldwide. This study aimed to evaluate a novel series of pyrazolo[4,3-e][1,2,4]triazine
Mateusz Kciuk, Gabriela Machura, Katarzyna Wanke, Sylwia Smarzewska, Mariusz Mojzych, Elżbieta Płuciennik, Renata Kontek   +6 more
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Evaluation of Multidentate Ligands Derived from Ethyl 1,2,4‐triazine‐3‐carboxylate Building Blocks as Potential An(III)‐Selective Extractants for Nuclear Reprocessing [PDF]

ChemistryOpen
Bis‐1,2,4‐triazine ligands are amongst the most promising soft N‐donor ligands for the partitioning of trivalent actinides from trivalent lanthanides; a key separation proposed in the future reprocessing of spent nuclear fuels.
Andrey V. Zaytsev, Petr Distler, Jan John, Andreas Wilden, Giuseppe Modolo, Mark Sims, Frank W. Lewis   +6 more
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Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in men and in women. The impact of the new pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide (MM-129) was evaluated against human colon cancer in vitro and in zebrafish
Justyna Magdalena Hermanowicz, Anna Szymanowska, Beata Sieklucka, Robert Czarnomysy, Krystyna Pawlak, Anna Bielawska, Krzysztof Bielawski, Joanna Kalafut, Alicja Przybyszewska, Arkadiusz Surazynski, Adolfo Rivero-Muller, Mariusz Mojzych, Dariusz Pawlak   +12 more
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The activity of pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
In the last decade, an increasing interest in compounds containing pyrazolo[4,3-e][1,2,4]triazine moiety is observed. Therefore, the aim of the research was to synthesise a novel sulphonyl pyrazolo[4,3-e][1,2,4]triazines (2a, 2b) and pyrazolo[4,3-e ...
Anna Szymanowska, Dominika Radomska, Robert Czarnomysy, Mariusz Mojzych, Katarzyna Kotwica-Mojzych, Krzysztof Bielawski, Anna Bielawska   +6 more
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Synthesis, Characterization, and Biological Evaluation of Novel 7-Oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic Acid Derivatives [PDF]

Molecules, 2020
A series of novel 7-oxo-7H-thiazolo[3,2-b]-1,2,4-triazine-2-carboxylic acid derivatives was synthesized in good yields by a multi-step procedure that included the generation of the S-alkylated derivatives from 6-substituted arylmethyl-3-mercapto-1,2,4 ...
Dong Cai, Tai Li, Qian Xie, Xiaofei Yu, Wei Xu, Yu Chen, Zhe Jin, Chun Hu   +7 more
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Potential of Triazines as Antidiabetic Agents—A Review of Structures and Pharmacological Activity [PDF]

Pharmaceuticals
Type 2 diabetes (T2D), a major global health challenge, represents approximately 96% of all cases of diabetes worldwide. Epidemiological forecasts indicate the prevalence of this disease could rise by almost 45% over the next 25 years.
Dorota Łażewska, Diana Strelchuk, Jadwiga Handzlik   +2 more
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