Results 11 to 20 of about 51,319 (173)

Synthesis and luminescence of 3-(pyridine-2-yl)-1,2,4-triazine-based Ir(III) complexes [PDF]

Chimica Techno Acta
A series of novel iridium(III) complexes containing 5-N-(aryl)-amino- or 5-cycloamino-3-(pyridine-2-yl)-1,2,4-triazine ligands was obtained. These complexes exhibited red luminescence in solution as well as in the solid state.
Basim S.M. Al-Ghezi, Igor S. Kovalev, Maria V. Sangalova, Alena A. Noskova, Albert F. Khasanov, Nikita S. Glebov, Yaroslav K. Shtaitz, Maria I. Valieva, Alexey P. Krinochkin, Olga V. Shabunina, Dmitry S. Kopchuk, Grigory V. Zyryanov   +11 more
doaj   +5 more sources

Synthesis of Some New Barbituric and Thiobarbituric Acids Bearing 1,2,4-Triazine Moiety and Their Related Systems as Herbicidal Agents

Journal of Chemistry, 2019
In search for highly bioactive barbituric and thiobarbituric acid derivatives, some new barbituric and thiobarbituric acids bearing 1,2,4-triazine moiety and their related systems (5–13) have been obtained from the addition of isocyanate and ...
Abeer N. Al-Romaizan
doaj   +2 more sources

The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite. [PDF]

Antimicrob Agents Chemother, 2021
Novel bis-1,2,4-triazine compounds with potent in vitro activity against Plasmodium falciparum parasites were recently identified. The bis-1,2,4-triazines represent a unique antimalarial pharmacophore and are proposed to act by a novel but as-yet-unknown
Ellis KM, Lucantoni L, Chavchich M, Abraham M, De Paoli A, Luth MR, Zeeman AM, Delves MJ, Terán FS, Straschil U, Baum J, Kocken CHM, Ralph SA, Winzeler EA, Avery VM, Edstein MD, Baell JB, Creek DJ.   +17 more
europepmc   +2 more sources

Revisiting the Synthesis of Functionally Substituted 1,4-Dihydrobenzo[e][1,2,4]triazines

Molecules, 2022
A series of novel 1,4-dihydrobenzo[1,2,4][e]triazines bearing an acetyl or ester moiety as a functional group at the C(3) atom of the 1,2,4-triazine ring were synthesized.
Margarita A. Epishina, Alexander S. Kulikov, Leonid L. Fershtat   +2 more
doaj   +1 more source

Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir [PDF]

, 2021
Pyrrolo[2,1-f][1,2,4]triazine (1) is an important regulatory starting material in the production of Remdesivir (Veklury®). Compound 1 was produced through a newly developed synthetic methodology utilizing the simple building blocks pyrrole ...
Gopal, Sirasani, Chris, Senanayake, Subho, Roy, Joseph D., Armstrong, B. Frank, Gupton, Ajay, Yadaw, Sarabindu, Roy, David, Snead   +7 more
core   +2 more sources

Synthesis of functionalized imidazo[4,5-e]thiazolo[3,2-b]triazines by condensation of imidazo[4,5-e]triazinethiones with DMAD or DEAD and rearrangement to imidazo[4,5-e]thiazolo[2,3-c]triazines

Beilstein Journal of Organic Chemistry, 2021
Two series of functionalized imidazothiazolotriazine derivatives were synthesized via the condensation of imidazo[4,5-e]-1,2,4-triazine-3-thiones with acetylenedicarboxylic acid dimethyl and diethyl esters (DMAD and DEAD) and subsequent base-catalyzed ...
Alexei N. Izmest’ev, Dmitry B. Vinogradov, Natalya G. Kolotyrkina, Angelina N. Kravchenko, Galina A. Gazieva   +4 more
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Synthesis of imidazo[4,5-e][1,3]thiazino[2,3-c][1,2,4]triazines via a base-induced rearrangement of functionalized imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazines

Beilstein Journal of Organic Chemistry, 2023
A series of imidazo[4,5-e][1,3]thiazino[2,3-c][1,2,4]triazines was synthesized via a cascade sequence of hydrolysis and skeletal rearrangement of imidazo[4,5-e]thiazolo[2,3-c][1,2,4]triazin-7(8H)-ylidene)acetic acid esters in methanol upon treatment with
Dmitry B. Vinogradov, Alexei N. Izmest’ev, Angelina N. Kravchenko, Yuri A. Strelenko, Galina A. Gazieva   +4 more
doaj   +1 more source

Bioactive Pyrrolo[2,1-f][1,2,4]triazines: Synthesis, Molecular Docking, In Vitro Cytotoxicity Assay and Antiviral Studies

Chemistry, 2023
A series of 2,4-disubstituted pyrrolo[2,1-f][1,2,4]triazines containing both aryl and thienyl substituents were synthesized by exploiting the 1,3-cycloaddition reaction of N(1)-ethyl-1,2,4-triazinium tetrafluoroborates with dimethyl ...
Nataliya N. Mochulskaya, Svetlana K. Kotovskaya, Ilya I. Butorin, Mikhail V. Varaksin, Valery N. Charushin, Vladimir L. Rusinov, Yana L. Esaulkova, Alexander V. Slita, Polina A. Ilyina, Vladimir V. Zarubaev   +9 more
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Tuning the Triazolotriazine Scaffold Toward Selective A₃ Adenosine Receptor Antagonists: From Molecular Recognition to Neuroprotection. [PDF]

ChemMedChem
Structure‐based optimization of the triazolo‐triazine scaffold afforded highly potent and selective adenosine A3 receptor antagonists. Replacement of the classical 2‐furyl group with phenyl‐based substituents markedly improved A3 receptor affinity and selectivity.
Kost V, Prencipe F, Panozzi F, Salmaso V, Kachler S, Klotz KN, Coppi E, Adorinni S, Moro S, Pugliese AM, Federico S, Spalluto G, Da Ros T.   +12 more
europepmc   +2 more sources

A convenient synthetic approach to 5-(het)arylhydrazine substituted 1,2,4-triazines

Chimica Techno Acta, 2020
A convenient synthesis of 1,2,4-triazines bearing the moieties of (hetero)arylhydrazines at the position of C5 of the 1,2,4-triazine core is reported.
A. P. Krinochkin, M. R. Guda, A. Rammohan, D. S. Kopchuk, G. V. Zyryanov, V. L. Rusinov, O. N. Chupakhin   +6 more
doaj   +1 more source