Results 11 to 20 of about 6,154 (202)

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity [PDF]

Pharmaceuticals, 2023
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra, Ainur D. Sharapov, Ramil F. Fatykhov, Anastasya P. Potapova, Igor A. Khalymbadzha, Maria I. Valieva, Dmitry S. Kopchuk, Grigory V. Zyryanov, Alexander S. Bunev, Vsevolod V. Melekhin, Vasiliy S. Gaviko, Andrey A. Zonov   +11 more
doaj   +5 more sources

Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-e][1,2,4]triazine Derivatives [PDF]

Molecules, 2020
This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-e][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-e][1,2,4]triazolo[4,3-b][1,2,4]triazines and pyrazolo[4,3-e ...
Zofia Bernat, Anna Szymanowska, Mateusz Kciuk, Katarzyna Kotwica-Mojzych, Mariusz Mojzych   +4 more
doaj   +2 more sources

6-Amino-3,4-dimethyl-1,2,4-triazin-1-ium 2-anilinobenzoate–3-amino-5,6-dimethyl-1,2,4-triazine (1/1) [PDF]

IUCrData, 2017
In the title molecular salt, C5H9N4+·C13H10NO2−·C5H8N4, the asymmetric unit consists of a 6-amino-3,4-dimethyl-1,2,4-triazin-1-ium cation, a 2-anilinobenzoate anion and a neutral 3-amino-5,6-dimethyl-1,2,4-triazine molecule. The typical intramolecular N..
Ramalingam Sangeetha, Kasthuri Balasubramani, Kaliyaperumal Thanigaimani, Ibrahim Abdul Razak   +3 more
doaj   +5 more sources

A theoretical study on the corrosion inhibition of Cu surfaces using 4-amino-3-thioxo-6-methyl-1,2,4-triazine-5-one and its derivatives [PDF]

Scientific Reports
The current study focused on evaluating the behavior of 4-amino-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2 H)-one (1a) along with its tautomers, as well as 4-amino-6-methyl-3-thioxo-3,4-dihydro-1,2,4-triazin-5(2 H)-one (2a) and its tautomers as potential ...
Zahra Jafarzadegan, Alireza Najafi Chermahini, Hossein Farrokhpour, Majid Mir Mohammad Sadeghi   +3 more
doaj   +2 more sources

Evaluation of Multidentate Ligands Derived from Ethyl 1,2,4‐triazine‐3‐carboxylate Building Blocks as Potential An(III)‐Selective Extractants for Nuclear Reprocessing [PDF]

ChemistryOpen
Bis‐1,2,4‐triazine ligands are amongst the most promising soft N‐donor ligands for the partitioning of trivalent actinides from trivalent lanthanides; a key separation proposed in the future reprocessing of spent nuclear fuels.
Andrey V. Zaytsev, Petr Distler, Jan John, Andreas Wilden, Giuseppe Modolo, Mark Sims, Frank W. Lewis   +6 more
doaj   +2 more sources

Exploration of novel heterofused 1,2,4-triazine derivative in colorectal cancer [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in men and in women. The impact of the new pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide (MM-129) was evaluated against human colon cancer in vitro and in zebrafish
Justyna Magdalena Hermanowicz, Anna Szymanowska, Beata Sieklucka, Robert Czarnomysy, Krystyna Pawlak, Anna Bielawska, Krzysztof Bielawski, Joanna Kalafut, Alicja Przybyszewska, Arkadiusz Surazynski, Adolfo Rivero-Muller, Mariusz Mojzych, Dariusz Pawlak   +12 more
doaj   +2 more sources

Exploring the Subtle Effect of Aliphatic Ring Size on Minor Actinide Extraction Properties and Metal Ion Speciation in Bis‐1,2,4‐Triazine Ligands [PDF]

Chemistry, 2020
The synthesis and evaluation of three novel bis‐1,2,4‐triazine ligands containing five‐membered aliphatic rings are reported. Compared to the more hydrophobic ligands 1–3 containing six‐membered aliphatic rings, the distribution ratios for relevant f ...
Bulmer, Rachel, Geist, Andreas, Kozhevnikov, Valery, Lewis, Frank, Modolo, Giuseppe, Panak, Petra, Sims, Mark, Waddell, Paul, Wessling, Patrik, Wilden, Andreas, Zaytsev, Andrey   +10 more
core   +3 more sources

The activity of pyrazolo[4,3-e][1,2,4]triazine and pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulphonamide derivatives in monolayer and spheroid breast cancer cell cultures [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
In the last decade, an increasing interest in compounds containing pyrazolo[4,3-e][1,2,4]triazine moiety is observed. Therefore, the aim of the research was to synthesise a novel sulphonyl pyrazolo[4,3-e][1,2,4]triazines (2a, 2b) and pyrazolo[4,3-e ...
Anna Szymanowska, Dominika Radomska, Robert Czarnomysy, Mariusz Mojzych, Katarzyna Kotwica-Mojzych, Krzysztof Bielawski, Anna Bielawska   +6 more
doaj   +2 more sources

2-(3-Chloro-5,6-diphenyl-2,5-dihydro-1,2,4-triazin-5-yl)-2-methylpropanenitrile [PDF]

Acta Crystallographica Section E, 2012
The title compound, C19H17ClN4, was obtained from the reaction of 3-chloro-5,6-diphenyl-1,2,4-triazine with isobutyronitrile in the presence of lithium diisopropylamide as an unexpected product of covalent addition of isobutyronitrile carbanion to the C ...
Ewa Wolińska, Zbigniew Karczmarzyk, Andrzej Rykowski, Zofia Urbańczyk-Lipkowska, Przemysław Kalicki   +4 more
doaj   +5 more sources

3-Methyl-sulfanyl-5-phenyl-1,2,4-triazine. [PDF]

Acta Crystallogr Sect E Struct Rep Online, 2014
In the molecule of the title compound, C10H9N3S, the dihedral angle between the triazine and phenyl rings is 11.77 (7)°. In the crystal, molecules are linked by π–π stacking interactions [centroid–centroid distances = 3.7359 (3) and 3.7944 (4) Å], forming layers parallel to thebcplane.
Hamri S, Hafid A, Khouili M, El Ammari L, Ketatni el M.   +4 more
europepmc   +5 more sources