Results 111 to 120 of about 51,319 (173)

Annelation of the 1,2,4-Triazine Core to 2,3-Benzodiazepine

Журнал органічної та фармацевтичної хімії
A one-pot, stepwise method for the annelation of the 1,2,4-triazine core to the seven-membered 2,3-benzodiazepine ring via the interaction of the corresponding 2,3-benzodiazepin-1-yl- or 2,3-benzodiazepin-4-ylhydrazines with α-ketoesters has been ...
Natalia M. Bohdan, Serhii I. Shuvakin, Diana S. Nechaieva, Sergii Yu. Suikov, Serhii L. Bohza   +4 more
doaj   +1 more source

Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as an Important Scaffold for Anticancer Drug Discovery-In Vitro and In Silico Evaluation. [PDF]

Int J Mol Sci, 2023
Kciuk M, Marciniak B, Celik I, Zerroug E, Dubey A, Sundaraj R, Mujwar S, Bukowski K, Mojzych M, Kontek R.   +9 more
europepmc   +1 more source

Investigating the Structure-Activity Relationship of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists. [PDF]

J Med Chem, 2022
Mahindra A, Jenkins L, Marsango S, Huggett M, Huggett M, Robinson L, Gillespie J, Rajamanickam M, Morrison A, McElroy S, Tikhonova IG, Milligan G, Jamieson AG.   +12 more
europepmc   +1 more source

Genotoxicity of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides in Normal and Cancer Cells In Vitro. [PDF]

Int J Mol Sci, 2023
Kciuk M, Mujwar S, Marciniak B, Gielecińska A, Bukowski K, Mojzych M, Kontek R.   +6 more
europepmc   +1 more source

Synthesis and antifungal activity of 4-substituted-3, 7 –dimethylpyrazolo [3,4-e] [1,2,4] triazine

, 2002
664-667A convenient synthesis and antifungal activity of four compounds namely 2-(3, 7-dimethyl-4H-pyrazolo[3,4-e][1,2,4]triazin-4-yl)acetic acid 2, 3,7-dimethyl-4-(4-methylphenyl-pyrazolo[3,4-e][1,2,4]triazine 3, 4-(3,7-dimethyl-4H-pyrazolo[3,4-e][1 ...
Tewari, Ashish Kumar, Verma, H N, Mishra, Anil, Mishra, Lily   +3 more
core  

Discovery of the 3-Amino-1,2,4-triazine-Based Library as Selective PDK1 Inhibitors with Therapeutic Potential in Highly Aggressive Pancreatic Ductal Adenocarcinoma. [PDF]

Int J Mol Sci, 2023
Carbone D, De Franco M, Pecoraro C, Bassani D, Pavan M, Cascioferro S, Parrino B, Cirrincione G, Dall'Acqua S, Moro S, Gandin V, Diana P.   +11 more
europepmc   +1 more source

Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides as Novel Potential Anticancer Agents: Apoptosis, Oxidative Stress, and Cell Cycle Analysis. [PDF]

Int J Mol Sci, 2023
Bukowski K, Marciniak B, Kciuk M, Mujwar S, Mojzych M, Kontek R.   +5 more
europepmc   +1 more source

Structural Manipulations of Marine Natural Products Inspire a New Library of 3-Amino-1,2,4-Triazine PDK Inhibitors Endowed with Antitumor Activity in Pancreatic Ductal Adenocarcinoma. [PDF]

Mar Drugs, 2023
Carbone D, De Franco M, Pecoraro C, Bassani D, Pavan M, Cascioferro S, Parrino B, Cirrincione G, Dall'Acqua S, Sut S, Moro S, Gandin V, Diana P.   +12 more
europepmc   +1 more source

Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy. [PDF]

Med Chem Res, 2022
Singh S, Utreja D, Kumar V.
europepmc   +1 more source

Preparation of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides and Their Experimental and Computational Biological Studies. [PDF]

Int J Mol Sci, 2022
Kciuk M, Mujwar S, Szymanowska A, Marciniak B, Bukowski K, Mojzych M, Kontek R.   +6 more
europepmc   +1 more source