Results 1 to 10 of about 2,622 (202)

Evaluating acridones as novel therapeutics for human babesiosis [PDF]

Antimicrobial Agents and Chemotherapy
Human babesiosis is an emerging tick-borne disease caused by Babesia parasites, most notably Babesia microti and Babesia duncani in North America and Babesia divergens in Europe.
Pratap Vydyam, Elizabeth Zhang, Anasuya C. Pal, Rozalia A. Dodean, Papireddy Kancharla, Jane X. Kelly, Choukri Ben Mamoun   +6 more
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Acridone Derivatives for Near-UV Radical Polymerization: One-Component Type II vs. Multicomponent Behaviors [PDF]

Molecules
In this work, two novel acridone-based photoinitiators were designed and synthesized for the free radical polymerization of acrylates with a light-emitting diode emitting at 405 nm.
Adel Noon, Francesco Calogero, Andrea Gualandi, Hiba Hammoud, Tayssir Hamieh, Joumana Toufaily, Fabrice Morlet-Savary, Michael Schmitt, Pier Giorgio Cozzi, Jacques Lalevée   +9 more
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New Acridone- and (Thio)Xanthone-Derived 1,1-Donor–Acceptor-Substituted Alkenes: pH-Dependent Fluorescence and Unusual Photooxygenation Properties

Molecules, 2021
A synthetic route to new heterocyclic 1,1-donor–acceptor-substituted alkenes starting with N-methyl-acridone, xanthone, and thioxanthone was investigated, leading to the acridone- and xanthone-derived products methyl 2-methoxy-2-(10-methylacridin-9 (10H)-
Tim Lippold, Jörg M. Neudörfl, Axel Griesbeck   +2 more
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Synthesis and Application in Cell Imaging of Acridone Derivatives

Applied Sciences, 2020
Tricyclic acridone derivatives have been extensively developed as antimicrobial, antimalarial, and antitumor drugs due to their broad spectrum of drug design and biological activity.
Yung-Chieh Chan, Chia-Ying Li, Chin-Wei Lai, Min-Wei Wu, Hao-Jui Tseng, Cheng-Chung Chang   +5 more
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Development of Acridone Derivatives: Targeting c-MYC Transcription in Triple-Negative Breast Cancer with Inhibitory Potential [PDF]

Antioxidants, 2023
Breast cancer, especially the aggressive triple-negative subtype, poses a serious health threat to women. Unfortunately, effective targets are lacking, leading to a grim prognosis. Research highlights the crucial role of c-MYC overexpression in this form
Jing-Wei Liang, Zhi-Chao Gao, Lu-Lu Yang, Wei Zhang, Ming-Zhe Chen, Fan-Hao Meng   +5 more
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Synthetic Modifications of a Pb²⁺-Sensor Acridono-Crown Ether for Covalent Attachment and Their Effects on Selectivity [PDF]

Molecules
Because of environmental impact, there is a great need for chemosensors, especially for toxic heavy metals such as lead. The conventional instrumental analytical techniques rarely provide an available real-time sensing platform, thus the development of ...
Panna Vezse, Martin Gede, Ádám Golcs, Péter Huszthy, Tünde Tóth   +4 more
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Potent acridone antimalarial against all three life stages of Plasmodium [PDF]

Nature Communications
Antimalarial therapeutics ideally should target all three major Plasmodium life cycle stages. Here we present an acridone antimalarial chemotype that is potent against blood, liver, and mosquito stages of malaria parasites.
Papireddy Kancharla, Rozalia A. Dodean, Yuexin Li, Xiaowei Zhang, Sean Kelly, Jordan Charlton, Angely J. Binauhan, Kimberly Navarrete, Laurize Garcia, Jianbing Mu, Jinghua Lu, Diana Caridha, Michael S. Madejczyk, Xiannu Jin, William E. Dennis, Karl Kudyba, Sharon McEnearney, Patricia J. Lee, Cameron Blount, Jesse DeLuca, Chau Vuong, Kristina Pannone, Hieu T. Dinh, Kennedy Mdaki, Susan Leed, Monica L. Martin, Brandon S. Pybus, Geoffrey C. Chin, Anongruk Chim-Ong, Liwang Cui, Tarrick Qahash, Douglas A. Shoue, Michael T. Ferdig, Frank P. Mockenhaupt, Welmoed van Loon, Jules M. Ndoli, Heather Kudyba, Joel Vega-Rodriguez, Martin Okitwi, Oriana Kreutzfeld, Cristina Docan, Carol Green, Ying Liu, Aaron Agulay, Jon Mirsalis, Sarah N. Farrell, Alexandra S. Probst, Aaron Nilsen, P. Holland Alday, J. Stone Doggett, Geoffrey I. McFadden, Christopher D. Goodman, Flaminia Catteruccia, Philip J. Rosenthal, Michael K. Riscoe, Roland A. Cooper, Alison Roth, Jane X. Kelly   +57 more
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Synthesis and Biological Evaluation of Acridone Derivatives for Antimicrobial and Antifungal Applications [PDF]

Journal of Experimental Pharmacology
Ali Salman Al-Shami,1,2 Jalal Alkadsi3 1Department of Pharmacology, Faculty of Medicine, Sanaa University, Sanaa City, Republic of Yemen; 2Jiblah University for Medical and Health Science, Ibb City, Republic of Yemen; 3Department of Medicinal Chemistry ...
Al-Shami AS, Alkadsi J
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Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity [PDF]

Communications Biology
Quinolone synthase from Aegle marmelos (AmQNS) is a type III polyketide synthase that yields therapeutically effective quinolone and acridone compounds. Addressing the structural and molecular underpinnings of AmQNS and its substrate interaction in terms
Mallika Vijayanathan, Abhinav Koyamangalath Vadakkepat, Kozhinjampara R. Mahendran, Abdoallah Sharaf, Kristian E. H. Frandsen, Debashree Bandyopadhyay, M. Radhakrishna Pillai, Eppurath Vasudevan Soniya   +7 more
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Study of Combinatorial Drug Synergy of Novel Acridone Derivatives With Temozolomide Using in-silico and in-vitro Methods in the Treatment of Drug-Resistant Glioma

Frontiers in Oncology, 2021
Drug resistance is one of the critical challenges faced in the treatment of Glioma. There are only limited drugs available in the treatment of Glioma and among them Temozolomide (TMZ) has shown some effectiveness in treating Glioma patients, however, the
Malobika Chakravarty, Piyali Ganguli, Piyali Ganguli, Manikanta Murahari, Ram Rup Sarkar, Ram Rup Sarkar, Godefridus Johannes Peters, Godefridus Johannes Peters, Y. C. Mayur   +8 more
doaj   +1 more source