Results 1 to 10 of about 5,634 (238)

Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study, three series of novel polysubstituted N-alkyl acridone analogous were designed and synthesised as HDAC isoform-selective inhibitors.
Ze Wang, Li Zhao, Bo Zhang, Jiahe Feng, Yule Wang, Bin Zhang, Haixiao Jin, Lijian Ding, Ning Wang, Shan He   +9 more
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Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity

Pharmaceuticals, 2023
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra, Ainur D. Sharapov, Ramil F. Fatykhov, Anastasya P. Potapova, Igor A. Khalymbadzha, Maria I. Valieva, Dmitry S. Kopchuk, Grigory V. Zyryanov, Alexander S. Bunev, Vsevolod V. Melekhin, Vasiliy S. Gaviko, Andrey A. Zonov   +11 more
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Acridone Derivatives from Atalantia monophyla Inhibited Cancer Cell Proliferation through ERK Pathway

Molecules, 2022
The present study aimed to investigate the effect of acridone alkaloids on cancer cell lines and elucidate the underlying molecular mechanisms. The ten acridone alkaloids from Atalantia monophyla were screened for cytotoxicity against LNCaP cell lines by
Wen-Yong Gao, Chantana Boonyarat, Pitchayakarn Takomthong, Kusawadee Plekratoke, Yoshihiro Hayakawa, Chavi Yenjai, Rawiwun Kaewamatawong, Suchada Chaiwiwatrakul, Pornthip Waiwut   +8 more
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Study of Combinatorial Drug Synergy of Novel Acridone Derivatives With Temozolomide Using in-silico and in-vitro Methods in the Treatment of Drug-Resistant Glioma

Frontiers in Oncology, 2021
Drug resistance is one of the critical challenges faced in the treatment of Glioma. There are only limited drugs available in the treatment of Glioma and among them Temozolomide (TMZ) has shown some effectiveness in treating Glioma patients, however, the
Malobika Chakravarty, Piyali Ganguli, Piyali Ganguli, Manikanta Murahari, Ram Rup Sarkar, Ram Rup Sarkar, Godefridus Johannes Peters, Godefridus Johannes Peters, Y. C. Mayur   +8 more
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Development of Acridone Derivatives: Targeting c-MYC Transcription in Triple-Negative Breast Cancer with Inhibitory Potential [PDF]

Antioxidants, 2023
Breast cancer, especially the aggressive triple-negative subtype, poses a serious health threat to women. Unfortunately, effective targets are lacking, leading to a grim prognosis. Research highlights the crucial role of c-MYC overexpression in this form
Jing-Wei Liang, Zhi-Chao Gao, Lu-Lu Yang, Wei Zhang, Ming-Zhe Chen, Fan-Hao Meng   +5 more
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Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe

Molecules, 2021
Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and ...
Mikhail Panfilov, Darya Chernova, Irina Khalfina, Alexander Moskalensky, Aleksey Vorob’ev   +4 more
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Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli

Microbial Cell Factories, 2020
Background Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial effects. Certain plant species such
Gyu-Sik Choi, Hye Jeong Choo, Bong-Gyu Kim, Joong-Hoon Ahn   +3 more
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Acridone Derivatives for Near-UV Radical Polymerization: One-Component Type II vs. Multicomponent Behaviors [PDF]

Molecules
In this work, two novel acridone-based photoinitiators were designed and synthesized for the free radical polymerization of acrylates with a light-emitting diode emitting at 405 nm.
Adel Noon, Francesco Calogero, Andrea Gualandi, Hiba Hammoud, Tayssir Hamieh, Joumana Toufaily, Fabrice Morlet-Savary, Michael Schmitt, Pier Giorgio Cozzi, Jacques Lalevée   +9 more
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A New Coumarin-Acridone Compound as a Fluorescence Probe for Fe³⁺ and Its Application in Living Cells and Zebrafish

Molecules, 2021
A new coumarin-acridone fluorescent probe S was designed and synthesized, and the structure was confirmed with 1H/13C NMR spectrometry, single-crystal X-ray diffraction, and high-resolution mass spectrometry.
Jiayong Huang, Zhenshuo Yan, Peiling Qiu, Yufeng Mo, Qizhen Cao, Qiuhong Li, Lini Huo, Lichun Zhao   +7 more
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Synthetic Modifications of a Pb²⁺-Sensor Acridono-Crown Ether for Covalent Attachment and Their Effects on Selectivity [PDF]

Molecules
Because of environmental impact, there is a great need for chemosensors, especially for toxic heavy metals such as lead. The conventional instrumental analytical techniques rarely provide an available real-time sensing platform, thus the development of ...
Panna Vezse, Martin Gede, Ádám Golcs, Péter Huszthy, Tünde Tóth   +4 more
doaj   +2 more sources