Results 1 to 10 of about 2,340 (207)

Transformation of acridone synthase to chalcone synthase [PDF]

FEBS Letters, 2001
Acridone synthase (ACS) and chalcone synthase (CHS) catalyse the pivotal reactions in the formation of acridone alkaloids or flavonoids. While acridone alkaloids are confined almost exclusively to the Rutaceae, flavonoids occur abundantly in all seed‐bearing plants.
Richard Lukačin, Ulrich Matern
exaly   +4 more sources

Acridone Derivatives for Near-UV Radical Polymerization: One-Component Type II vs. Multicomponent Behaviors [PDF]

Molecules
In this work, two novel acridone-based photoinitiators were designed and synthesized for the free radical polymerization of acrylates with a light-emitting diode emitting at 405 nm.
Adel Noon, Francesco Calogero, Andrea Gualandi, Hiba Hammoud, Tayssir Hamieh, Joumana Toufaily, Fabrice Morlet-Savary, Michael Schmitt, Pier Giorgio Cozzi, Jacques Lalevée   +9 more
doaj   +4 more sources

Development of Acridone Derivatives: Targeting c-MYC Transcription in Triple-Negative Breast Cancer with Inhibitory Potential [PDF]

Antioxidants, 2023
Breast cancer, especially the aggressive triple-negative subtype, poses a serious health threat to women. Unfortunately, effective targets are lacking, leading to a grim prognosis. Research highlights the crucial role of c-MYC overexpression in this form
Jing-Wei Liang, Zhi-Chao Gao, Lu-Lu Yang, Wei Zhang, Ming-Zhe Chen, Fan-Hao Meng   +5 more
doaj   +2 more sources

New Acridone- and (Thio)Xanthone-Derived 1,1-Donor–Acceptor-Substituted Alkenes: pH-Dependent Fluorescence and Unusual Photooxygenation Properties

Molecules, 2021
A synthetic route to new heterocyclic 1,1-donor–acceptor-substituted alkenes starting with N-methyl-acridone, xanthone, and thioxanthone was investigated, leading to the acridone- and xanthone-derived products methyl 2-methoxy-2-(10-methylacridin-9 (10H)-
Tim Lippold, Jörg M. Neudörfl, Axel Griesbeck   +2 more
doaj   +2 more sources

Evaluating acridones as novel therapeutics for human babesiosis. [PDF]

Antimicrob Agents Chemother
ABSTRACT Human babesiosis is an emerging tick-borne disease caused by Babesia parasites, most notably Babesia microti and Babesia duncani ...
Vydyam P, Zhang E, Pal AC, Dodean RA, Kancharla P, Kelly JX, Ben Mamoun C.   +6 more
europepmc   +4 more sources

Synthetic Modifications of a Pb²⁺-Sensor Acridono-Crown Ether for Covalent Attachment and Their Effects on Selectivity [PDF]

Molecules
Because of environmental impact, there is a great need for chemosensors, especially for toxic heavy metals such as lead. The conventional instrumental analytical techniques rarely provide an available real-time sensing platform, thus the development of ...
Panna Vezse, Martin Gede, Ádám Golcs, Péter Huszthy, Tünde Tóth   +4 more
doaj   +2 more sources

Potent acridone antimalarial against all three life stages of Plasmodium [PDF]

Nature Communications
Antimalarial therapeutics ideally should target all three major Plasmodium life cycle stages. Here we present an acridone antimalarial chemotype that is potent against blood, liver, and mosquito stages of malaria parasites.
Papireddy Kancharla, Rozalia A. Dodean, Yuexin Li, Xiaowei Zhang, Sean Kelly, Jordan Charlton, Angely J. Binauhan, Kimberly Navarrete, Laurize Garcia, Jianbing Mu, Jinghua Lu, Diana Caridha, Michael S. Madejczyk, Xiannu Jin, William E. Dennis, Karl Kudyba, Sharon McEnearney, Patricia J. Lee, Cameron Blount, Jesse DeLuca, Chau Vuong, Kristina Pannone, Hieu T. Dinh, Kennedy Mdaki, Susan Leed, Monica L. Martin, Brandon S. Pybus, Geoffrey C. Chin, Anongruk Chim-Ong, Liwang Cui, Tarrick Qahash, Douglas A. Shoue, Michael T. Ferdig, Frank P. Mockenhaupt, Welmoed van Loon, Jules M. Ndoli, Heather Kudyba, Joel Vega-Rodriguez, Martin Okitwi, Oriana Kreutzfeld, Cristina Docan, Carol Green, Ying Liu, Aaron Agulay, Jon Mirsalis, Sarah N. Farrell, Alexandra S. Probst, Aaron Nilsen, P. Holland Alday, J. Stone Doggett, Geoffrey I. McFadden, Christopher D. Goodman, Flaminia Catteruccia, Philip J. Rosenthal, Michael K. Riscoe, Roland A. Cooper, Alison Roth, Jane X. Kelly   +57 more
doaj   +2 more sources

Synthesis and Biological Evaluation of Acridone Derivatives for Antimicrobial and Antifungal Applications [PDF]

Journal of Experimental Pharmacology
Ali Salman Al-Shami,1,2 Jalal Alkadsi3 1Department of Pharmacology, Faculty of Medicine, Sanaa University, Sanaa City, Republic of Yemen; 2Jiblah University for Medical and Health Science, Ibb City, Republic of Yemen; 3Department of Medicinal Chemistry ...
Al-Shami AS, Alkadsi J
doaj   +2 more sources

Structural and mechanistic insights into Quinolone Synthase to address its functional promiscuity [PDF]

Communications Biology
Quinolone synthase from Aegle marmelos (AmQNS) is a type III polyketide synthase that yields therapeutically effective quinolone and acridone compounds. Addressing the structural and molecular underpinnings of AmQNS and its substrate interaction in terms
Mallika Vijayanathan, Abhinav Koyamangalath Vadakkepat, Kozhinjampara R. Mahendran, Abdoallah Sharaf, Kristian E. H. Frandsen, Debashree Bandyopadhyay, M. Radhakrishna Pillai, Eppurath Vasudevan Soniya   +7 more
doaj   +2 more sources

Discovery of novel polysubstituted N-alkyl acridone analogues as histone deacetylase isoform-selective inhibitors for cancer therapy [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study, three series of novel polysubstituted N-alkyl acridone analogous were designed and synthesised as HDAC isoform-selective inhibitors.
Ze Wang, Li Zhao, Bo Zhang, Jiahe Feng, Yule Wang, Bin Zhang, Haixiao Jin, Lijian Ding, Ning Wang, Shan He   +9 more
doaj   +2 more sources