Results 11 to 20 of about 2,340 (207)

Synthesis and Application in Cell Imaging of Acridone Derivatives

Applied Sciences, 2020
Tricyclic acridone derivatives have been extensively developed as antimicrobial, antimalarial, and antitumor drugs due to their broad spectrum of drug design and biological activity.
Yung-Chieh Chan, Chia-Ying Li, Chin-Wei Lai, Min-Wei Wu, Hao-Jui Tseng, Cheng-Chung Chang   +5 more
doaj   +2 more sources

Two New Acridone Alkaloids from Glycosmis macrantha [PDF]

Molecules, 2011
Extraction and chromatographic separation of the extracts of dried stem barks of Glycosmis macrantha lead to isolation of two new acridone alkaloids, macranthanine (1) and 7-hydroxynoracronycine (2), and a known acridone, atalaphyllidine (3).
Abdah Md Akim, Mohd Aspollah Sukari, Muhammad Aizat Mohd Amin, Mawardi Rahmani, Gwendoline Cheng Lian Ee, Najihah Mohd Hashim, Maizatul Akmal Yahayu   +6 more
doaj   +2 more sources

Design and Synthesis of New Acridone-Based Nitric Oxide Fluorescent Probe

Molecules, 2021
Nitric oxide (NO) is an important signaling molecule involved in a wide range of physiological and pathological processes. Fluorescent imaging is a useful tool for monitoring NO concentration, which could be essential in various biological and ...
Mikhail Panfilov, Darya Chernova, Irina Khalfina, Alexander Moskalensky, Aleksey Vorob’ev   +4 more
doaj   +2 more sources

Acridone Derivatives from Atalantia monophyla Inhibited Cancer Cell Proliferation through ERK Pathway

Molecules, 2022
The present study aimed to investigate the effect of acridone alkaloids on cancer cell lines and elucidate the underlying molecular mechanisms. The ten acridone alkaloids from Atalantia monophyla were screened for cytotoxicity against LNCaP cell lines by
Wen-Yong Gao, Chantana Boonyarat, Pitchayakarn Takomthong, Kusawadee Plekratoke, Yoshihiro Hayakawa, Chavi Yenjai, Rawiwun Kaewamatawong, Suchada Chaiwiwatrakul, Pornthip Waiwut   +8 more
doaj   +2 more sources

Study of Combinatorial Drug Synergy of Novel Acridone Derivatives With Temozolomide Using in-silico and in-vitro Methods in the Treatment of Drug-Resistant Glioma

Frontiers in Oncology, 2021
Drug resistance is one of the critical challenges faced in the treatment of Glioma. There are only limited drugs available in the treatment of Glioma and among them Temozolomide (TMZ) has shown some effectiveness in treating Glioma patients, however, the
Malobika Chakravarty, Piyali Ganguli, Piyali Ganguli, Manikanta Murahari, Ram Rup Sarkar, Ram Rup Sarkar, Godefridus Johannes Peters, Godefridus Johannes Peters, Y. C. Mayur   +8 more
doaj   +2 more sources

Microwave-Assisted Regioselective Synthesis and 2D-NMR Studies of New 1,2,3-Triazole Compounds Derived from Acridone

Journal of Chemistry, 2021
A simple and mild protocol towards the synthesis of new 1,2,3-triazole compounds derived from acridone has been developed via regiospecific 1,3-dipolar cycloaddition reaction between 10-(prop-2-yn-1-yl)acridone derivatives and aromatic azides using CuI ...
Mohammed Aarjane, Siham Slassi, Bouchra Tazi, Amina Amine   +3 more
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A Metallosupramolecular Receptor for Squaraine Dyes Enabling Ultrafast Dark Resonance Energy Transfer. [PDF]

Angew Chem Int Ed Engl
A metallosupramolecular receptor binds squaraine dyes with high affinity and enables efficient dark resonance energy transfer (DRET) that generates bright near‐infrared emission with large pseudo‐Stokes shifts. ABSTRACT A metal‐organic cage was obtained by combining acridone‐based dipyridyl ligands with Pd2+ ions. The cage acts as a potent receptor for
Chen DW, Deshpande T, Collignon S, Fadaei-Tirani F, Feldmann S, Severin K.   +5 more
europepmc   +3 more sources

Citrus reticulata Blanco: A Review on Chemical Composition and Biological Activities. [PDF]

Chem Biodivers
This review compiles chemical information and biological activities from 49 studies on Citrus reticulata. The fruit peels stand out for their high content of methoxylated monoterpenes and flavonoids with antioxidant, anti‐inflammatory, and antimicrobial activities.
Castro JWG, Souza GGO, da Costa JGM, Rodrigues FFG.   +3 more
europepmc   +2 more sources

Synthesis of acridone derivatives via heterologous expression of a plant type III polyketide synthase in Escherichia coli

Microbial Cell Factories, 2020
Background Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial effects. Certain plant species such
Gyu-Sik Choi, Hye Jeong Choo, Bong-Gyu Kim, Joong-Hoon Ahn   +3 more
doaj   +1 more source

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity

Pharmaceuticals, 2023
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra, Ainur D. Sharapov, Ramil F. Fatykhov, Anastasya P. Potapova, Igor A. Khalymbadzha, Maria I. Valieva, Dmitry S. Kopchuk, Grigory V. Zyryanov, Alexander S. Bunev, Vsevolod V. Melekhin, Vasiliy S. Gaviko, Andrey A. Zonov   +11 more
doaj   +1 more source