Results 41 to 50 of about 5,634 (238)
ALCALOIDES ACRIDÔNICOS INIBEM CATEPSINA L E V
Química Nova, 2016 Cathepsins represent a class of enzymes that has the primary function of randomly degrading proteins in the lysosomes, although are also involved in different pathologies.
Emerson F. Marques +2 more
doaj +1 more source
Design, Synthesis and biological evaluation of novel acridine-polyamine conjugates against prostate cancer [PDF]
, 2009 Prostate cancer is the most common cause of cancer death in men, aged 85 and over. Androgen receptor, a single polypeptide with three functional domains is very important during initiation and progression of the disease.
Karodia, N, Maurice, HB, Phillips, Roger
core
Acridone alkaloids. X. 13C-Nuclear magnetic resonance spectra of acridone alkaloids.
Chemical and Pharmaceutical Bulletin, 1983 The 13C-nuclear magnetic resonance spectra of twenty-seven acridone alkaloids including angular pyrano [2, 3-c] acridones and linear pyrano [3, 2-b] acridones have been analyzed and assigned. The information should be useful for the structure elucidation of new acridone alkaloids.
HIROSHI FURUKAWA +2 more
openaire +2 more sources
Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations
Angewandte Chemie International Edition, EarlyView.The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach +4 more
wiley +1 more source
1-Hydroxy-3,4-dimethoxy-10-methylacridin-9-one
IUCrData, 2020 There are two independent molecules in the asymmetric unit of the title compound, C16H15NO4, which was isolated from fruits of Zanthoxylum leprieurii. The atoms of the three rings of each molecule are close to coplanar with the largest deviations from ...
Rodrigo S. A. de Araújo +5 more
doaj +1 more source
Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents
Chemistry – A European Journal, EarlyView.This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley +1 more source
The FEBS Journal, EarlyView.Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova +5 more
wiley +1 more source
ChemSusChem, Volume 19, Issue 7, 14 April 2026.Aqueous micellar catalysis using industrially sourced rhamnolipids enables efficient Pd‐catalyzed N‐arylation of o‐acylanilines at 40°C. This surfactant‐driven system offers a sustainable and more efficient alternative to organic solvents, combining broad substrate scope, low catalyst loading, and enhanced energy efficiency.
Attila R. Herczegh +3 more
wiley +1 more source
Journal of Chemistry, 2022 3-(Vinyl-/buta-1,3-dien-1-yl/4-phenylbuta-1,3-dien-1-yl)-4-chloro quinolines and quinolin-4(1H)-ones were synthesized by ultrasound-assisted Wittig reaction of the corresponding 4-chloro-3-formylquinoline and 3-formylquinolin-4(1H)-ones with ...
Wahiba Frites +4 more
doaj +1 more source
Electrochimica Acta, 2021 Acridones have found their role in luminescent materials for OLEDs. Most interestingly, showing potential as weak charge transfer thermally activated delayed fluorescence (TADF) emitters, providing narrow photoluminescence.
M. Vasylieva +7 more
semanticscholar +1 more source