Results 51 to 60 of about 2,340 (207)

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N-alkyl-acridones and N,N′-dialkyl-9,9′-biacridylidenes

Biomolecules, 2019
The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have been developed and evaluated for their anti-cancer properties.
Marios G. Krokidis, Zara Molphy, Eleni K. Efthimiadou, Marianna Kokoli, Smaragda-Maria Argyri, Irini Dousi, Annalisa Masi, Kyriakos Papadopoulos, Andrew Kellett, Chryssostomos Chatgilialoglu   +9 more
doaj   +1 more source

Ultrasound-Assisted Wittig Reaction for the Synthesis of 3-Substituted 4-Chloroquinolines and Quinolin-4(1H)-ones with Extended π-Conjugated Systems

Journal of Chemistry, 2022
3-(Vinyl-/buta-1,3-dien-1-yl/4-phenylbuta-1,3-dien-1-yl)-4-chloro quinolines and quinolin-4(1H)-ones were synthesized by ultrasound-assisted Wittig reaction of the corresponding 4-chloro-3-formylquinoline and 3-formylquinolin-4(1H)-ones with ...
Wahiba Frites, Massaab Khalfaoui, Lamouri Hammal, Vera L. M. Silva, Artur M. S. Silva   +4 more
doaj   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, Volume 293, Issue 9, Page 2673-2691, May 2026.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Synthesis and nuclease activity of some 'porphyrin-acridone' hybrid molecules

, 1993
A short synthesis of several 'porphyrin-acridone' hybrids 4a-e based on 5-(4-hydroxyphenyl)10,15,20-tris(p-tolyl)porphyrin 1 and observations on their photoinitiated nuclease activity are ...
Maiya, Bhaskar G., Sambaiah, Thota, Sirish, Mallena, Mehta, Goverdhan, Chatterjee, Dipankar   +4 more
core   +1 more source

Degrees of Sulfonation: Mapping the Reactivity Landscape of Acridine and Acridone

Organics
Although sulfonated acridines and acridones are valuable scaffolds in diagnostics and materials science, to our best knowledge, there is no comprehensive study that addresses how the degree of sulfonation depends on reaction parameters. To fill this gap,
Péter Kisfaludi, Sára Spátay, Péter Huszthy, Ádám Golcs   +3 more
doaj   +1 more source

Development of Mild Palladium‐Catalyzed N‐Arylation of Ortho‐Acylanilines in Rhamnolipid Micellar System

ChemSusChem, Volume 19, Issue 7, 14 April 2026.
Aqueous micellar catalysis using industrially sourced rhamnolipids enables efficient Pd‐catalyzed N‐arylation of o‐acylanilines at 40°C. This surfactant‐driven system offers a sustainable and more efficient alternative to organic solvents, combining broad substrate scope, low catalyst loading, and enhanced energy efficiency.
Attila R. Herczegh, Péter R. Kollár, Johannes Lehmann, Zoltán Novák   +3 more
wiley   +1 more source

Acridone alkaloids from the rhizomes of Luvunga scandens (Roxb.) Buch. Ham.

, 2018
The ethyl acetate extract of the rhizomes of Luvunga scandens (Roxb.) Buch. - Ham. ex Wight & Arn (Rutaceae) delivered one new acridone alkaloid named Luvungaside A (1) together with three known acridone alkaloids, namely 1,3-dihydroxy-2-methoxy-10 ...
Dinh Tri Mai (689087), Luu Hong Truong (3802102), Tan Phat Nguyen (689085), Thi Hong Tuoi Do (3703798), Minh Nhat Phan (5951270), Nguyen Kim Tuyen Pham (3118668), Nguyen Minh An Tran (5951267), Dung Tien Le (119213)   +7 more
core   +1 more source

SYNTHESIS AND ANTINEOPLASTIC ACTIVITY OF CERTAIN TRIAZENE AND TRIAZENO-ACRIDINE COMBILEXIN DERIVATIVES [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 2007
Four series of bifunctional ligands have been synthesized as DNA-binding combilexins. These novel agents contain a triazenobenzene sulfonamide linker moiety that is attached to an intercalating acridine or acridone chromophore by a functionalized amide ...
Noha Amin, Nagwa Abdel Gawad, Mohammed Mohammed, Hanan Georgey, Samir Aly   +4 more
doaj   +1 more source

A Unique Topoisomerase II Inhibitor with Dose-Affected Anticancer Mechanisms and Less Cardiotoxicity

Cells, 2021
Type II DNA topoisomerase (topo II) is an essential nuclear enzyme and a well-validated anticancer drug target. Previously, we have carried out several rounds of structural optimizations on our in-house topo II inhibitor E17, which was shown to have ...
Zhi-Ying Li, Guang-Sen Xu, Xun Li
doaj   +1 more source