Novel 3,9-Disubstituted Acridines with Strong Inhibition Activity against Topoisomerase I: Synthesis, Biological Evaluation and Molecular Docking Study [PDF]
Molecules, 2023 A series of novel 3,9-disubstituted acridines were synthesized and their biological potential was investigated. The synthetic plan consists of eight reaction steps, which produce the final products, derivatives 17a–17j, in a moderate yield.
Kristína Krochtová +5 more
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Can Zeolite-Supporting Acridines Boost Their Anticancer Performance? [PDF]
Journal of Functional Biomaterials, 2023 Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the
Maja Ranković +9 more
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Effects of Acridines on Morphogenesis
Nature, 1968 EARLY studies of the effects of acridines on amphibian egg development tended to show that RNA synthesis is required for neural induction1. Little could be concluded from these experiments, however, because the acridines available at that time were a complex mixture of substances of unknown mode of action. Acridines have since been found to bind to and
J Brachet
exaly +4 more sources
Synthesis, Stability, and Biological Evaluation of Novel Aminoderivatives Incorporating the Aza-Acridine Scaffold [PDF]
MoleculesSeveral new amino-substituted aza-acridine derivatives bearing one or two basic side chains have been designed and synthesized. Their anticancer activities were evaluated in vitro against two human cancer cell lines: T24 (urothelial bladder carcinoma ...
Maria Karelou +6 more
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Synthesis of New Bis- and Tetra-Acridines
Molecules, 2001 A new series of bis- and tetra-acridines has been prepared from 4-(bromomethyl) acridine; some of them exhibited encouraging in vitro cytotoxic activities against murine cell lines.
Valerie Pique, Jean-Pierre Galy
exaly +3 more sources
New Boron Containing Acridines: Synthesis and Preliminary Biological Study [PDF]
Molecules, 2023 The synthesis of the first conjugates of acridine with cobalt bis(dicarbollide) are reported. A novel 9-azido derivative of acridine was prepared through the reaction of 9-methoxyacridine with N3CH2CH2NH2, and its solid-state molecular structure was ...
Anna A. Druzina +7 more
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Synthesis of N-acyl carbazoles, phenoxazines and acridines from cyclic diaryliodonium salts [PDF]
Beilstein Journal of Organic ChemistryN-Acyl carbazoles can be efficiently produced through a single-step process using amides and cyclic diaryliodonium triflates. This convenient reaction is facilitated by copper iodide in p-xylene, using the commonly found activating ligand diglyme.
Nils Clamor +4 more
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Synthesis and Electrophilic Substitution of Pyrido[2,3,4-Kl]-Acridines
Molecules, 2001 Several new pyrido[2,3,4-kl]acridines were synthesized by reacting naphthoquinone, juglone or cyclohexan-1,3-dione with β,β’-diaminoketones in a biomimetic reaction. The structure of all new compounds was elucidated by NMR and MS spectroscopy.
Yoel Kashman, Amira Rudi
exaly +3 more sources
Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines. [PDF]
PLoS ONE, 2013 G-quadruplexes are higher-order DNA structures formed from guanine-rich sequences, and have been identified as attractive anticancer drug targets.
Ruben Ferreira +7 more
doaj +1 more source
New 9-aminoacridine derivatives as inhibitors of Botulinum neurotoxins and P. falciparum malaria [PDF]
Journal of the Serbian Chemical Society, 2013 Steroidal and adamantane aminoacridine derivatives were prepared and tested as both botulinum neurotoxin (BoNT) inhibitors and antimalarials. Steroid-bound acridines provided good potency against both the BoNT/A and BoNT/B light chains (LCs ...
Tot Mikloš +6 more
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