Results 1 to 10 of about 2,207 (215)
Structure and Stability of Human Telomeric G-Quadruplex with Preclinical 9-Amino Acridines [PDF]
PLoS ONE, 2013 G-quadruplexes are higher-order DNA structures formed from guanine-rich sequences, and have been identified as attractive anticancer drug targets.
Ramon Eritja +2 more
exaly +2 more sources
Novel 3,9-Disubstituted Acridines with Strong Inhibition Activity against Topoisomerase I: Synthesis, Biological Evaluation and Molecular Docking Study [PDF]
Molecules, 2023 A series of novel 3,9-disubstituted acridines were synthesized and their biological potential was investigated. The synthetic plan consists of eight reaction steps, which produce the final products, derivatives 17a–17j, in a moderate yield.
Kristína Krochtová +5 more
doaj +2 more sources
Synthesis of new Bis- and Tetra-Acridines
Molecules, 2001 A new series of bis- and tetra-acridines has been prepared from 4-(bromomethyl) acridine; some of them exhibited encouraging in vitro cytotoxic activities against murine cell lines.
Valerie Piqué, Jean-Pierre Galy
exaly +3 more sources
Synthesis and Electrophilic Substitution of Pyrido[2,3,4-kl]-acridines
Molecules, 2001 Several new pyrido[2,3,4-kl]acridines were synthesized by reacting naphthoquinone, juglone or cyclohexan-1,3-dione with β,β’-diaminoketones in a biomimetic reaction. The structure of all new compounds was elucidated by NMR and MS spectroscopy.
Yoel Kashman, Amira Rudi
exaly +3 more sources
New 9-aminoacridine derivatives as inhibitors of Botulinum neurotoxins and P. falciparum malaria [PDF]
Journal of the Serbian Chemical Society, 2013 Steroidal and adamantane aminoacridine derivatives were prepared and tested as both botulinum neurotoxin (BoNT) inhibitors and antimalarials. Steroid-bound acridines provided good potency against both the BoNT/A and BoNT/B light chains (LCs ...
Tot Mikloš +6 more
doaj +1 more source
Pharmaceuticals, 2022 Nowadays, leishmaniasis constitutes a public health issue in more than 88 countries, affecting mainly people from the tropics, subtropics, and the Mediterranean area. Every year, the prevalence of this infectious disease increases, with the appearance of
Carlos F. M. Silva +3 more
doaj +1 more source
Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
Pharmaceuticals, 2021 The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and
Stephen Neidle
doaj +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2021 In the title compound, C27H33NO5, a 3,3,6,6-tetramethyltetrahydroacridine-1,8-dione ring system carries an ethyl acetate substituent on the acridine N atom and an o-hydroxyphenyl ring on the central methine C atom of the dihydropyridine ring. The benzene
Omyma A. A. Abd Allah +5 more
doaj +1 more source
Molecules, 2022 Oral squamous cell carcinoma (OSCC) is a global public health problem with high incidence and mortality. The chemotherapeutic agents used in the clinic, alone or in combination, usually lead to important side effects.
Bruna Costa Zorzanelli +13 more
doaj +1 more source
The crystallography of acridine. III. The structure of acridine II [PDF]
Acta Crystallographica, 1960 A three-dimensional analysis of a second crystalline form of acridine is described.
Phillips, D.C. +2 more
openaire +1 more source