Results 11 to 20 of about 2,207 (215)

Can Zeolite-Supporting Acridines Boost Their Anticancer Performance? [PDF]

Journal of Functional Biomaterials, 2023
Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the
Maja Ranković, Anka Jevremović, Aleksandra Janošević Ležaić, Aleksandar Arsenijević, Jelena Rupar, Vladimir Dobričić, Bojana Nedić Vasiljević, Nemanja Gavrilov, Danica Bajuk-Bogdanović, Maja Milojević-Rakić   +9 more
doaj   +2 more sources

Acridine as an Anti-Tumour Agent: A Critical Review [PDF]

Molecules, 2022
This review summarized the current breakthroughs in the chemistry of acridines as anti-cancer agents, including new structural and biologically active acridine attributes.
Potlapati Varakumar, Kalirajan Rajagopal, Baliwada Aparna, Kannan Raman, Gowramma Byran, Clara Mariana Gonçalves Lima, Salma Rashid, Mohammed H. Nafady, Talha Bin Emran, Sławomir Wybraniec   +9 more
doaj   +2 more sources

Synthesis, Stability, and Biological Evaluation of Novel Aminoderivatives Incorporating the Aza-Acridine Scaffold [PDF]

Molecules
Several new amino-substituted aza-acridine derivatives bearing one or two basic side chains have been designed and synthesized. Their anticancer activities were evaluated in vitro against two human cancer cell lines: T24 (urothelial bladder carcinoma ...
Maria Karelou, Anthi Panara, Eleftheria Chatziorfanou, Aikaterini F. Giannopoulou, Dimitrios J. Stravopodis, Evagelos Gikas, Ioannis K. Kostakis   +6 more
doaj   +2 more sources

New Boron Containing Acridines: Synthesis and Preliminary Biological Study [PDF]

Molecules, 2023
The synthesis of the first conjugates of acridine with cobalt bis(dicarbollide) are reported. A novel 9-azido derivative of acridine was prepared through the reaction of 9-methoxyacridine with N3CH2CH2NH2, and its solid-state molecular structure was ...
Anna A. Druzina, Nadezhda V. Dudarova, Ivan V. Ananyev, Anastasia A. Antonets, Dmitry N. Kaluzhny, Alexey A. Nazarov, Igor B. Sivaev, Vladimir I. Bregadze   +7 more
doaj   +2 more sources

In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II [PDF]

Pharmaceuticals
Background: Sulfonamide acridine derivatives have garnered significant attention from medicinal chemists due to their diverse range of biological activities. Methods: In this study, eleven compounds were synthesized according to the literature, and their
Mohamed Badr, Elshaymaa I. Elmongy, Doaa Elkhateeb, Yasmine S. Moemen, Ashraf Khalil, Hadeer Ali, Reem Binsuwaidan, Feby Awadallah, Ibrahim El Tantawy El Sayed   +8 more
doaj   +2 more sources

Synthesis of N-acyl carbazoles, phenoxazines and acridines from cyclic diaryliodonium salts [PDF]

Beilstein Journal of Organic Chemistry
N-Acyl carbazoles can be efficiently produced through a single-step process using amides and cyclic diaryliodonium triflates. This convenient reaction is facilitated by copper iodide in p-xylene, using the commonly found activating ligand diglyme.
Nils Clamor, Mattis Damrath, Thomas J. Kuczmera, Daniel Duvinage, Boris J. Nachtsheim   +4 more
doaj   +2 more sources

Synthesis, Biological Evaluation and Stability Studies of Some Novel Aza-Acridine Aminoderivatives

Molecules, 2020
Several new amino-substituted aza-acridine derivatives bearing a basic side chain have been designed and synthesized. The antiproliferative activity of the target compounds has been evaluated against three cancer cell lines—namely HCT-116 (colorectal ...
Maria Karelou, Vasileios Kourafalos, Athanasia P. Tragomalou, Panagiotis Marakos, Nicole Pouli, Ourania E. Tsitsilonis, Evangelos Gikas, Ioannis K. Kostakis   +7 more
doaj   +1 more source

STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Zagazig Journal of Pharmaceutical Sciences, 1994
Although acridines and many tricyclic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents,
Mohamed Al-Ashmawi , Mohamed El-Sadek , Mohamed El-Bermawy, Ashraf Kadry , Osama Al-Sabbagh   +4 more
doaj   +1 more source

Comparison of Association Constants of Cyclodextrins and Their tert-Butyl Derivatives With Halogenbenzoic Acids and Acridine Derivatives

Molecules, 2001
Association constants of complexes of a new class of cyclodextrin alkyl derivatives - randomly susbstituted tert-butyl derivatives (TB-CDs) with complete set of mono-halobenzoic acids and acridine derivatives were measured using capillary electrophoresis
Josef Jůza, Jindřich Jindřich, Ivan Jelínek, Radka Matalová, Martin Pumera   +4 more
doaj   +1 more source

Acridine form IX [PDF]

Acta Crystallographica Section E Crystallographic Communications, 2019
We report a new polymorph of acridine, C13H9N, denoted form IX, obtained as thin needles by slow evaporation of a toluene solution. The structure was solved and refined from powder X-ray data. The structures of five unsolvated forms were previously known, but this is only the second with one molecule in the asymmetric unit.
Peter W. Stephens, Einat Schur, Saul H. Lapidus, Joel Bernstein   +3 more
openaire   +3 more sources