Results 11 to 20 of about 3,278 (246)

Synthesis of Acridines through Alkyne Addition to Diarylamines

Molecules, 2018
A new synthesis of substituted acridines is achieved by palladium-catalyzed addition of terminal acetylenes between the aryl rings of bis(2-bromophenyl)amine.
Kristen E. Berger, Grant M. McCormick, Joseph A. Jaye, Christina M. Rozeske, Eric H. Fort   +4 more
doaj   +2 more sources

Evolution of Acridines and Xanthenes as a Core Structure for the Development of Antileishmanial Agents

Pharmaceuticals, 2022
Nowadays, leishmaniasis constitutes a public health issue in more than 88 countries, affecting mainly people from the tropics, subtropics, and the Mediterranean area. Every year, the prevalence of this infectious disease increases, with the appearance of
Carlos F. M. Silva, Diana C. G. A. Pinto, Pedro A. Fernandes, Artur M. S. Silva   +3 more
doaj   +1 more source

Synthesis of N-acyl carbazoles, phenoxazines and acridines from cyclic diaryliodonium salts [PDF]

, 2023
N-Acyl carbazoles can be efficiently produced through a single-step process using amides and cyclic diaryliodonium triflates. This convenient reaction is facilitated by copper iodide in p-xylene, using the commonly found activating ligand diglyme.
Daniel, Duvinage, Boris Johannes, Nachtsheim, Nils, Clamor, Thomas, Kuczmera, Mattis, Damrath   +4 more
core   +2 more sources

Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids

Pharmaceuticals, 2021
The role of G-quadruplexes in human cancers is increasingly well-defined. Accordingly, G-quadruplexes can be suitable drug targets and many small molecules have been identified to date as G-quadruplex binders, some using computer-based design methods and
Stephen Neidle
doaj   +1 more source

Crystal structure and Hirshfeld surface analysis of ethyl 2-[9-(2-hydroxyphenyl)-3,3,6,6-tetramethyl-1,8-dioxo-2,3,4,4a,5,6,7,8a,9,9a,10,10a-dodecahydroacridin-10-yl]acetate

Acta Crystallographica Section E: Crystallographic Communications, 2021
In the title compound, C27H33NO5, a 3,3,6,6-tetramethyltetrahydroacridine-1,8-dione ring system carries an ethyl acetate substituent on the acridine N atom and an o-hydroxyphenyl ring on the central methine C atom of the dihydropyridine ring. The benzene
Omyma A. A. Abd Allah, Manpreet Kaur, Mehmet Akkurt, Shaaban K. Mohamed, Jerry P. Jasinski, Sahar M. I. Elgarhy   +5 more
doaj   +1 more source

Pro-Apoptotic Antitumoral Effect of Novel Acridine-Core Naphthoquinone Compounds against Oral Squamous Cell Carcinoma

Molecules, 2022
Oral squamous cell carcinoma (OSCC) is a global public health problem with high incidence and mortality. The chemotherapeutic agents used in the clinic, alone or in combination, usually lead to important side effects.
Bruna Costa Zorzanelli, Gabriel Ouverney, Fernanda P. Pauli, Anna Carolina Carvalho da Fonseca, Elan Cardozo Paes de Almeida, Danielle Gonçalves de Carvalho, Patricia Abrão Possik, Vitor Won-Held Rabelo, Paula Alvarez Abreu, Bruno Pontes, Vitor Francisco Ferreira, Luana da Silva Magalhães Forezi, Fernando de Carvalho da Silva, Bruno Kaufmann Robbs   +13 more
doaj   +1 more source

The crystallography of acridine. III. The structure of acridine II [PDF]

Acta Crystallographica, 1960
A three-dimensional analysis of a second crystalline form of acridine is described.
Phillips, D.C., Ahmed, F.R., Barnes, W.H.   +2 more
openaire   +1 more source

Are acridines mutagenic for Neurospora? [PDF]

, 1964
Are acridines mutagenic for ...
Reissig, J. L., J. L. Reissig
core   +1 more source

Synthesis, Biological Evaluation and Stability Studies of Some Novel Aza-Acridine Aminoderivatives

Molecules, 2020
Several new amino-substituted aza-acridine derivatives bearing a basic side chain have been designed and synthesized. The antiproliferative activity of the target compounds has been evaluated against three cancer cell lines—namely HCT-116 (colorectal ...
Maria Karelou, Vasileios Kourafalos, Athanasia P. Tragomalou, Panagiotis Marakos, Nicole Pouli, Ourania E. Tsitsilonis, Evangelos Gikas, Ioannis K. Kostakis   +7 more
doaj   +1 more source

STRUCTURE-ACTIVITY INVESTIGATION OF ATYPICAL ACRIDINE DERIVATIVES AS ANTIMICROBIAL AGENTS

Zagazig Journal of Pharmaceutical Sciences, 1994
Although acridines and many tricyclic compounds are known to possess potent antimicrobial activity, yet most of these compounds are either toxic (cannot be used systemically) or have other pharmacological activities. To develop safe and effective agents,
Mohamed Al-Ashmawi , Mohamed El-Sadek , Mohamed El-Bermawy, Ashraf Kadry , Osama Al-Sabbagh   +4 more
doaj   +1 more source