Results 41 to 50 of about 2,191 (200)

Neodymium‐Doped Nanocrystals for Sensing Cellular Temperature at the Nanoscale

Advanced Optical Materials, EarlyView.
Neodymium‐doped NaYF4 nanocrystals are engineered as bright, biocompatible nanothermometers for intracellular temperature mapping. Their ratiometric near‐infrared emission enables highly sensitive, nanoscale thermal readouts in living cells. Combined with gold nanostars for photothermal therapy, they reveal pronounced subcellular heating heterogeneity ...
Maria Bravo, Sandra Krzyzowska, Shelly Yang, Dingchen Wen, Jana Zielinski, Farsai Taemaitree, Samantha Zaman, Alastair Stewart, Susana Rocha, Paul Mulvaney, Hiroshi Uji‐i, Beatrice Fortuni, Sam Brooke, James Hutchison   +13 more
wiley   +1 more source

Development of New Amides Based on Acridine: Synthesis, Antibacterial, Cytotoxic, and Molecular Docking Evaluation [PDF]

Iranian Journal of Chemistry & Chemical Engineering
The ongoing endeavor to synthesize new antibacterial compounds is essential in overcoming bacterial resistance, as this poses a serious threat to the survival of the human race.
Atena Shabestarian, Mehdi Pordel, Mohammad Reza Bozorgmehr   +2 more
doaj   +1 more source

Pathogen‐Centric Activation of an Azoreductase‐Responsive Antibody‐Antibiotic Conjugate for the Targeted Eradication of MRSA

Advanced Science, EarlyView.
A pathogen‐centric antibody‐antibiotic conjugate (AZO‐AAC) releases antibiotics via bacterial azoreductase, independent of host‐lysosomal function. This mechanism achieves nanomolar eradication of both planktonic and intracellular methicillin‐resistant Staphylococcus aureus (MRSA).
Qi Cheng, Lianqi Liu, Chenghua Liu, Fei Xie, Jingwen Dong, Xiaoyu Qin, Shunxiang Huang, Xian Li, Xingyuan Kou, Hongbin Deng, Jiannan Feng, Wu Zhong, Dian Xiao, Xinbo Zhou   +13 more
wiley   +1 more source

Synthesis of Acridines through Alkyne Addition to Diarylamines

Molecules, 2018
A new synthesis of substituted acridines is achieved by palladium-catalyzed addition of terminal acetylenes between the aryl rings of bis(2-bromophenyl)amine.
Kristen E. Berger, Grant M. McCormick, Joseph A. Jaye, Christina M. Rozeske, Eric H. Fort   +4 more
doaj   +1 more source

Dual‐Stage Microneedle Patch With Lipid Droplet‐Mediated ‘Capture‐Kill’ and Sustained Release for Enhanced Wound Healing

Advanced Science, EarlyView.
We report a lipid‐droplet‐engineered, gallium‐loaded sonodynamic therapeutic platform (LDTG) incorporated into a bilayer microneedle (MN) patch co‐delivering all‐trans retinoic acid (ATRA), termed LDTG A‐MNs, for synergistic antibacterial therapy and accelerated wound repair.
Peng Jiang, Meijun Jiang, Jiapeng Lei, Wen Zhang, Huiyuan Yang, Xueyang Wang, Siyu Zhang, Qiongfang Ruan, Shuhua Liu, Wei Li   +9 more
wiley   +1 more source

SIRT6‐Mediated Deacetylation of ATF3 Promotes Silica‐Induced Lung Fibrosis by Enhancing its Nuclear Import via Binding to Importin α

Advanced Science, EarlyView.
SIRT6‐mediated ATF3 acetylation drives MGARP transcription and mitochondrial dysfunction in macrophages, promoting macrophage senescence and pulmonary fibrosis. Mechanistically, HSP70/Importin α competitively binds to ATF3, modulating its nuclear translocation.
Demin Cheng, Wenxia Bu, Fengxu Wang, Yueyuan Jin, Rongzhu Liu, Rui Zhao, Xuehai Wang, Mengna Jiang, Jinping Shen, Xinhang Cheng, Zuming Chen, Li Zhu, Jinlong Li, Zhenzhong Ge, Shichen Miao, Haotian Xu, Xiaoyu Zhou, Dongming Wang, Xinyuan Zhao   +18 more
wiley   +1 more source

Efficient and Convenient Synthesis of 1,8-Dioxodecahydroacridine Derivatives Using Cu-Doped ZnO Nanocrystalline Powder as a Catalyst under Solvent-Free Conditions

The Scientific World Journal, 2013
A simple and convenient one-step method for synthesis of acridines and their derivatives from condensation of aromatic aldehydes, cyclic diketones, and aryl amines using Cu-doped ZnO nanocrystalline powder as a catalyst is reported.
Heshmatollah Alinezhad, Sahar Mohseni Tavakkoli   +1 more
doaj   +1 more source

Correlation between anti-malarial and anti-haemozoin activities of anti-malarial compounds

Malaria Journal, 2020
Background Despite noticeable improvement in anti-malarial treatment, rapid growth of resistant malaria strains points out the need for continuous development of novel anti-malarials to fight the disastrous infection.
Dao Ngoc Hien Tam, Gehad Mohamed Tawfik, Amr Ehab El-Qushayri, Ghaleb Muhammad Mehyar, Sedralmontaha Istanbuly, Sedighe Karimzadeh, Vo Linh Tu, Ranjit Tiwari, Truong Van Dat, Phuong Thuy Viet Nguyen, Kenji Hirayama, Nguyen Tien Huy   +11 more
doaj   +1 more source

Aromatic Iodides: Synthesis and Conversion to Heterocycles

Chemistry Proceedings, 2022
Aromatic heterocycles can be found in many molecules endowed with specific properties, in particular for applications in the fields of medicinal chemistry and materials science.
Florence Mongin, William Erb, Frédéric Lassagne   +2 more
doaj   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, EarlyView.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source