Results 61 to 70 of about 2,207 (215)
Biotechnology and Bioengineering, EarlyView.ABSTRACT The recent clinical adoption of cell therapies has increased the need for more efficient, robust, and reproducible manufacturing technologies. Human mesenchymal stromal cells (hMSCs), a major component of the cell and immunotherapeutic market, remain challenging to manufacture at scale because they require surface attachment and are highly ...
William S. Skinner +7 more
wiley +1 more source
Synthesis, DNA-Binding and Antiproliferative Properties of Acridine and 5-Methylacridine Derivatives
Molecules, 2012 Several acridine derivatives were synthesized and their anti-proliferative activity was determined. The most active molecules were derivatives of 5-methylacridine-4-carboxylic acid. The DNA binding properties of the synthesized acridines were analyzed by
Ramon Eritja +3 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.The synthesis of dithieno[3,2‐b:2′,3′‐e]pyridines (DTPs) is herein reported, and their optical properties are studied both experimentally and computationally. Protonation or methylation of the nitrogen atom induced bathochromic shifts in their absorption and emission spectra.
Dominic Taylor +7 more
wiley +1 more source
9-phenyl acridine photosensitizes A375 cells to UVA radiation
Heliyon, 2020 Acridines are an important class of bioactive molecules having varied uses. Its derivative, 9-phenylacridine (ACPH) had been found to exhibit antitumor activity both in cell lines and in vivo model.
Surajit Hansda, Gargi Ghosh, Rita Ghosh
doaj +1 more source
Lysosome‐Targeted Squaramide Anion Transporters
Chemistry – A European Journal, EarlyView.Lysosome‐targeted squaramide anion transporters elicit different biological effects depending on the targeting group employed. ABSTRACT Targeting anion transporters to specific organelles has previously been shown to be an effective strategy to enhance their cytotoxicities against cancerous cell lines.
Elba Feo +5 more
wiley +1 more source
Characterization of the Interaction of Known G‐quadruplex Ligands With a Minimal i‐Motif Structure
Chemistry – A European Journal, EarlyView.The destabilization of a minimal i‐Motif (iM) structure by TMPyP4 is driven by ligand recognition of one terminal iM structural domain. ABSTRACT Peculiar genomic regions are prone to evolve transiently from double‐helix DNA to noncanonical secondary structures in response to physiological stress.
Davide Auricchio +3 more
wiley +1 more source
A review of published data on acridine derivatives with different biological activities [PDF]
Kragujevac Journal of Science, 2018 Acridine ring can be found in molecules used in many different spheres, including industry and medicine. Nowadays, even acridines with antibacterial activity are of research interest due to increasing bacterial resistance.
Rupar Jelena S. +4 more
doaj
Chemistry – A European Journal, EarlyView.A comprehensive experimental and theoretical study is presented of a family of TADF dyes. Comparing the behavior of structurally related dyes, we uncover the subtle and somewhat unexpected role of conformational degrees of freedom associated with peripheral groups that affect the delicate interplay of excited states that governs spin–orbit coupling ...
Andrea Landi +7 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A library of 21 tetrakis(phenothiazinyl)‐substituted silanes with broadly variable substituent decoration, which are fully reversible multistage redox systems with intense tunable emission from deep blue to yellow–green (441–533 nm), was rapidly synthesized by bromine–lithium exchange/borylation–Suzuki coupling of tetrakis(4‐bromophenyl)silane or by ...
Thomas P. M. Merke +4 more
wiley +1 more source