Results 51 to 60 of about 3,278 (246)

Efficient Protocol for Synthesis of Pyrazolo[3,4-a]acridines

, 2015
A new class of pyrazolo[3,4-a]acridines have been prepared. The synthon acridones were obtained in very good yield by a one-pot reaction of 2-amino-5-chloro or nitro substituted benzophenones with 1,3-cyclic diketones in the presence of freshly prepared ...
Rajendran Satheeshkumar (805344), Werner Kaminsky (734855), Karnam Jayarampillai Rajendra Prasad (565238), Hazel A. Sparkes (536438)   +3 more
core   +1 more source

Novel acridine-based thiosemicarbazones as ‘turn-on' chemosensors for selective recognition of fluoride anion: a spectroscopic and theoretical study [PDF]

Royal Society Open Science, 2018
New thiosemicarbazide-linked acridines 3a–c were prepared and investigated as chemosensors for the detection of biologically and environmentally important anions. The compounds 3a–c were found selective for fluoride (F−) with no affinity for other anions,
Ibanga Okon Isaac, Iqra Munir, Mariya al-Rashida, Syed Abid Ali, Zahid Shafiq, Muhammad Islam, Ralf Ludwig, Khurshid Ayub, Khalid Mohammed Khan, Abdul Hameed   +9 more
doaj   +1 more source

Molecular Signatures of HIV‐Induced Neuroinflammation and Neurodegeneration in Human Cerebral Organoids: Identification of Therapeutic Targets for NeuroHIV

Advanced Science, EarlyView.
HIV preferentially infects microglia, activating IL‐17A‐driven IFN‐γ/STAT1, CEBPB, and NF‐κB signaling that converges with cGAS‐STING and Notch–NEURL1 pathways, promoting neuroinflammation, mitochondrial dysfunction, and synaptic impairment. cART suppresses viral replication, attenuates inflammatory signaling, and at least partially restores ...
Karthick Chennakesavan, Malaroviyam Samikkannu, Shreyan Gupta, Olasunkanmi Israel Tayo, Arpan Acharya, James J. Cai, Siddappa N. Byrareddy, Thangavel Samikkannu   +7 more
wiley   +1 more source

Efficient novel synthesis of pyrano[3,2-a]- and pyrazolo[4,3-a]-acridines

, 2016
The synthesis of pyrano[3,2-a]acridines is presented, where 7-chloro-9-phenyl-2,3-dihydroacridin-4(1H)-one reacts with arylaldehydes and malononitrile in the presence of piperidine in ethanol, giving with high yield via a multicomponent method.
Rajendran Satheeshkumar (805344), Werner Kaminsky (734855), Karnam Jayarampillai Rajendra Prasad (565238)   +2 more
core   +1 more source

In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II

Pharmaceuticals
Background: Sulfonamide acridine derivatives have garnered significant attention from medicinal chemists due to their diverse range of biological activities. Methods: In this study, eleven compounds were synthesized according to the literature, and their
Mohamed Badr, Elshaymaa I. Elmongy, Doaa Elkhateeb, Yasmine S. Moemen, Ashraf Khalil, Hadeer Ali, Reem Binsuwaidan, Feby Awadallah, Ibrahim El Tantawy El Sayed   +8 more
doaj   +1 more source

Development of New Amides Based on Acridine: Synthesis, Antibacterial, Cytotoxic, and Molecular Docking Evaluation [PDF]

Iranian Journal of Chemistry & Chemical Engineering
The ongoing endeavor to synthesize new antibacterial compounds is essential in overcoming bacterial resistance, as this poses a serious threat to the survival of the human race.
Atena Shabestarian, Mehdi Pordel, Mohammad Reza Bozorgmehr   +2 more
doaj   +1 more source

Early‐Life Manganese Overexposure Activates Microglial Phagocytosis through the YY1/TREM2 Axis Leading to Hippocampal Synaptic Remodeling in Mice

Advanced Science, EarlyView.
Early‐life manganese exposure induces behavioral deficits and aberrant hippocampal synaptic remodeling by enhancing microglial phagocytosis in young adult male mice. Mechanistically, manganese promotes Yin Yang 1 (YY1)/triggering receptor expressed on myeloid cells 2 (TREM2) signaling through enhanced HIF1α‐mediated transcription and suppressed SMURF2 ...
Keyu Chen, Bin He, Kuan Liu, Zhuo Ma, Bin Xu   +4 more
wiley   +1 more source

Mutagenicity of Acridines in a Reversion Assay Based on Tetracycline Resistance in Plasmid pBR322 in Escherichia Coli [PDF]

, 1996
The mutagenicity of a series of acridine compounds was studied in an assay based on the reversion of mutations in the tetracycline-resistance gene (tet) of plasmid pBR322 in Escherichia coli.
Hoffman, George R., Fuchs, Robert P. P., Manyin, Teresa, Deschênes, Suzanne M.   +3 more
core  

Lithium‐Doped Hydroxyapatite Nanowires Rejuvenate Senescent Macrophages Via the Lysosome‐Dependent Ferroptosis Axis to Promote Aged Bone Regeneration

Advanced Science, EarlyView.
Li‐nHAP+GelMA promotes mandibular bone regeneration in aged mice by remodeling the senescent immune microenvironment. Local delivery of Li‐nHAP restores lysosomal homeostasis in senescent macrophages, reduces intracellular labile Fe2+ accumulation, ROS production, and lipid peroxidation, thereby suppressing macrophage ferroptosis and senescence ...
Baixi Chen, Ziduan Ding, Ruomei Li, Cheng Zhu, Zhiyu Zhu, Zitong Yang, Luyao Qu, Jin Hao, Lunguo Xia, Bing Fang, Lu Liu   +10 more
wiley   +1 more source

Über Tetrahydro‐acridin und eine neue Acridin‐Synthese [PDF]

Berichte der deutschen chemischen Gesellschaft, 1908
n ...
openaire   +2 more sources