Results 51 to 60 of about 4,550 (134)

Complexes of Pd(II) and Pt(II) with 9-aminoacridine: reactions with DNA and study of their antiproliferative activity

, 2013
Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and 1H, 13C, and 195Pt NMR spectroscopies. Crystal structure of the palladium complex of formulae [Pd(9AA)
Ciudad i Gómez, Carlos Julián, Font Bardia, Ma. Mercedes, Moreno Martínez, Virtudes, Noé Mata, Verónica, Riera, X., Solans, Xavier, 1949-2007   +5 more
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mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity [PDF]

, 2006
Type II Human DNA Topoisomerases (topos II) play an essential role in DNA replication and transcription and are important targets for cancer chemotherapeutic drugs.
Gilroy, Kathryn, Leontiou, Chrysoula, Padget, Kay, Lakey, Jeremy, Austin, Caroline   +4 more
core   +3 more sources

Correlation between anti-malarial and anti-haemozoin activities of anti-malarial compounds

Malaria Journal, 2020
Background Despite noticeable improvement in anti-malarial treatment, rapid growth of resistant malaria strains points out the need for continuous development of novel anti-malarials to fight the disastrous infection.
Dao Ngoc Hien Tam, Gehad Mohamed Tawfik, Amr Ehab El-Qushayri, Ghaleb Muhammad Mehyar, Sedralmontaha Istanbuly, Sedighe Karimzadeh, Vo Linh Tu, Ranjit Tiwari, Truong Van Dat, Phuong Thuy Viet Nguyen, Kenji Hirayama, Nguyen Tien Huy   +11 more
doaj   +1 more source

Efficient and Convenient Synthesis of 1,8-Dioxodecahydroacridine Derivatives Using Cu-Doped ZnO Nanocrystalline Powder as a Catalyst under Solvent-Free Conditions

The Scientific World Journal, 2013
A simple and convenient one-step method for synthesis of acridines and their derivatives from condensation of aromatic aldehydes, cyclic diketones, and aryl amines using Cu-doped ZnO nanocrystalline powder as a catalyst is reported.
Heshmatollah Alinezhad, Sahar Mohseni Tavakkoli   +1 more
doaj   +1 more source

Synthesis and Electrophilic Substitution of Pyrido[2,3,4-kl]-acridines

Molecules, 2001
Several new pyrido[2,3,4-kl]acridines were synthesized by reacting naphthoquinone, juglone or cyclohexan-1,3-dione with β,β’-diaminoketones in a biomimetic reaction. The structure of all new compounds was elucidated by NMR and MS spectroscopy.
Yoel Kashman, Marta Garcia Gravalos, Amira Rudi, Avi Koller   +3 more
doaj   +1 more source

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs [PDF]

, 2013
Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length.
A Canela, A Golubev, A Kowald, AE Bilsland, AJ Cesare, AJ Zaug, AM Zahler, Bartholomäus V. Hirt, BV Hirt, C Leonetti, C Schaffitzel, CJ Proctor, CJ Proctor, D Monchaud, E Henderson, EH Blackburn, F Wang, G Cristofari, G Wallweber, H Takai, HJ Lipps, I Rubelj, IA Rodriguez-Brenes, IA Sidorov, J Grasman, J Tang, JAD Wattis, JC Cookson, JD Griffith, Jonathan A. D. Wattis, K Masutomi, K Monier, KB Blagoev, L Hayflick, L Hayflick, L Oganesian, LA Johnson, M Gunaratnam, M Kimura, M Lei, M Macville, MA Collins, MK Cheng, MT Hemann, MT Teixeira, MZ Levy, N Arkus, NW Kim, O Arino, O Samassekou, O Wolkenhauer, P Abdallah, P Olofsson, P Olofsson, P Rosenau, P Wu, PD Sozou, PV Dmitriev, R Milo, RA Greenberg, RA Heald, RC Allsopp, S Neidle, SB Cohen, Simon P. Preston, SLB Knig, SM Gowan, SN Saldanha, SSS Poon, T Antal, T Lange de, T Lange de, T Lange de, T Richter, T Tauchi, T Zglinicki von, UM Martens, VL Makarov, W Palm, WE Wright, XY Dai, Y Xu, Y Zhao, Y Zhao   +83 more
core   +3 more sources

NUCLEIC-ACID BINDING-DRUGS .6. THE STRUCTURE OF 3,9-DIAMINO-7-ETHOXYACRIDINE (RIVANOL) AS THE LACTATE MONOHYDRATE SALT [PDF]

, 1982
C15H16N3 O+ • C3H50~-. H20, M r = 361.4, triclinic, Pi, with a = 7.912 (2), b = 10.016 (1), c = 12.246 (3)/k, = 107.75 (1),/~ = 103.08 (2), y = 94.47 (2) °, U = 888.9 ,/k 3, Z = 2, D m = 1.35 (2), D c = 1.350 Mg m -3, F(000) = 380, 2(Cu Ka) = 1.5418/~
AGGARWAL, A, NEIDLE, S
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Atomic Force Microscopy and Voltammetric Investigation of Quadruplex Formation between a Triazole-Acridine Conjugate and Guanine-Containing Repeat DNA Sequences [PDF]

, 2015
The interactions of the Tetrahymena telomeric repeat sequence d(TG4T) and the polyguanylic acid (poly(G)) sequence with the quadruplex-targeting triazole-linked acridine ligand GL15 were investigated using atomic force microscopy (AFM) at a highly ...
Chiorcea-Paquim, Ana-Maria, Eritja Casadellà, Ramón, Lucarelli, Genny, Neidle, Stephen, Oliveira-Brett, Ana Maria, Pontinha, Ana Dora Rodrigues Rodrigues, Sparapani, Silvia   +6 more
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Optical spectrum of proflavine and its ions

, 2010
Motivated by possible astrophysical and biological applications we calculate visible and near UV spectral lines of proflavine (C13H11N3, 3,6-diaminoacridine) in vacuum, as well as its anion, cation, and dication.
A. Bonaca, Bauschlicher, Becke, Castro, Castro, Clemett, De Silvestri, Destree, Ehrenfreund, G. Bilalbegović, Giannozzi, Godby, Herbig, Hirata, Hobbs, Hudgins, Jain, Jenniskens, Jones, Koch, Kokalj, Le Page, Lee, Lepp, Lerman, Malloci, Malloci, Marques, Martin, Mataga, Neumann, Perdew, Pileni, Rappe, Rocca, Runge, Sarre, Sarre, Sarre, Schulman, Snow, Thaddeus, Tielens, Tozzini, Troullier, Tuairisg, Varsano, Walker, Weisman, Yabana   +49 more
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A study of the feculae of Orthoptera, their specificity, and the role which the insects'mouthparts, alimentary canal, and food-habits play in their formation [PDF]

, 1962
2 láminasMany physiological studies have been carried out on different aspects of the feculae ("feces") and their formation in Orthoptera (sens. lat.).
Gangwere, S. K.
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