Results 31 to 40 of about 1,713 (173)

Chemical Metabolomics: Chemical Biology Tools for Advanced Metabolism Investigations

Angewandte Chemie, Volume 138, Issue 23, 1 June 2026.
The human metabolism has been investigated for several millennia. The metabolome is known for a high complexity due to a large number of different metabolites that are present at different concentrations. Metabolomics has been developed as a field to investigate the entire human metabolome and to elucidate disease development mechanisms.
Alejandro Torregrosa‐Chinillach, Ioanna Tsiara, Wawrzyniec Haberek, Weifeng Lin, Daniel Globisch   +4 more
wiley   +2 more sources

New acridone alkaloids from Ugandan Vepris trichocarpa

Scientific African
Ugandan Vepris trichocarpa sampled for this study yielded two undescribed acridone alkaloids here named trichouganda A (1), a 2‑methoxy derivative of evoxanthine (2), and trichouganda B (4), a 6‑methoxy derivative of 1,3,5-trimethoxy-10-methyl acridone ...
Papin Mucaleque, Moses K. Langat, Eduard Mas-Claret, Martin Cheek, Iain Darbyshire   +4 more
doaj   +1 more source

A Multi‐Stimuli Transformational Network of Benzil‐Based Pd(II) Assemblies

Angewandte Chemie International Edition, EarlyView.
Incorporation of a flexible and chemically reactive benzil backbone into the ligand structure allows it to access multiple conformations, enabling the formation of diverse homo‐ and heteroleptic Pd(II) assemblies with different nuclearities and topologies.
Zhiwei Zeng, A. Priscila Gia, Alexander S. Mikherdov, Mert Acar, Björn Schmidt, Guido H. Clever   +5 more
wiley   +1 more source

ALCALOIDES ACRIDÔNICOS INIBEM CATEPSINA L E V

Química Nova, 2016
Cathepsins represent a class of enzymes that has the primary function of randomly degrading proteins in the lysosomes, although are also involved in different pathologies.
Emerson F. Marques, Paulo C. Vieira, Richele P. Severino   +2 more
doaj   +1 more source

N‐Aryl Acridone Derivatives as Effective Catalysts for Energy Transfer Reactions

Chemistry – A European Journal, EarlyView.
Acridones derivatives have high triplet energy, are simple accessible, and could be used in challenging [2+2] ENT reactions. ABSTRACT Organic photocatalysts capable of promoting high‐energy triplet energy transfer (EnT) remain limited, particularly for demanding [2+2] photocycloaddition reactions.
Francesco Calogero, Gaetano D'Onghia, Federica Fina, Zakaria Ziani, Luca Sensoli, Andrea Gualandi, Andrea Fermi, Paola Ceroni, Pier Giorgio Cozzi   +8 more
wiley   +1 more source

1-Hydroxy-3,4-dimethoxy-10-methylacridin-9-one

IUCrData, 2020
There are two independent molecules in the asymmetric unit of the title compound, C16H15NO4, which was isolated from fruits of Zanthoxylum leprieurii. The atoms of the three rings of each molecule are close to coplanar with the largest deviations from ...
Rodrigo S. A. de Araújo, Ernestine N. T. Zondegoumba, Whisthler L. D. Tankoua, Barthelemy Nyassé, Francisco J. B. Mendonça-Junior, Carlos A. De Simone   +5 more
doaj   +1 more source

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source

Phytochemical and Biological Short Review Of Subfamily Aurantioideae. [PDF]

Records of Pharmaceutical & Biomedical Sciences
The subfamily Aurantioideae, belonging to the family Botany Rutaceae, represents one of the most economically and medicinally significant groups of flowering plants distributed throughout tropical and subtropical regions. This subfamily comprises several
Mareena Thabet
doaj   +1 more source

A New Coumarin-Acridone Compound as a Fluorescence Probe for Fe³⁺ and Its Application in Living Cells and Zebrafish

Molecules, 2021
A new coumarin-acridone fluorescent probe S was designed and synthesized, and the structure was confirmed with 1H/13C NMR spectrometry, single-crystal X-ray diffraction, and high-resolution mass spectrometry.
Jiayong Huang, Zhenshuo Yan, Peiling Qiu, Yufeng Mo, Qizhen Cao, Qiuhong Li, Lini Huo, Lichun Zhao   +7 more
doaj   +1 more source

Novel acridone derivatives probed using DFT, including design, synthesis, characterization with anti-oxidant and anti-mitotic screening

Results in Chemistry, 2023
Applying the Ullmann synthesis, substituted aniline and o-halobenzoic acids are combined with potassium carbonate and copper powder to produce N- (substituted phenyl) anthranilic acids.
S. Sulthanudeen, Predhanekar Mohamed Imran, M. Selvakumaran, Attar Kubaib   +3 more
doaj   +1 more source