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Current Perspectives on STING Agonists for Anticancer Drug Development. [PDF]
Chem Biol Drug DesThe molecular structures of STING agonists play a decisive role in regulating the STING pathway. Their distinct scaffolds and functional groups orchestrate receptor binding, conformational activation, and the subsequent immune response. ABSTRACT The cyclic GMP‐AMP (cGAS) synthase and stimulator of interferon genes signaling pathway plays a central role
Kahvecioglu Cicek D.
europepmc +2 more sources
Microbial Cell Factories, 2020 Background Acridone alkaloids are heterocyclic compounds that exhibit a broad-range of pharmaceutical and chemotherapeutic activities, including anticancer, antiviral, anti-inflammatory, antimalarial, and antimicrobial effects. Certain plant species such
Gyu-Sik Choi +3 more
doaj +1 more source
Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity
Pharmaceuticals, 2023 A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra +11 more
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Fermentative N-Methylanthranilate Production by Engineered Corynebacterium glutamicum
Microorganisms, 2020 The N-functionalized amino acid N-methylanthranilate is an important precursor for bioactive compounds such as anticancer acridone alkaloids, the antinociceptive alkaloid O-isopropyl N-methylanthranilate, the flavor compound O-methyl-N-methylanthranilate,
Tatjana Walter +9 more
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‘Acridines’ as New Horizons in Antifungal Treatment
Molecules, 2020 Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide.
Iwona Gabriel
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Frontiers in Materials, 2023 Understanding the functions of enzymes in various physiological processes is important, but the design of signaling probes for fast analysis of enzymatic activity is particularly challenging.
Meicen Liu +11 more
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Fitoquímica e quimiossistemática de Conchocarpus marginatus e C. inopinatus (Rutaceae)
Química Nova, 2012 Phytochemical studies of the leaves and stem have led to the identification of the known acridone alkaloids arborinine, methyl-arborinine, 1-hydroxy-3-methoxy-N-methyl acridone, xanthoxoline, 1,2,3,5-tetramethoxy-N-methylacridone, toddaliopsin C and the ...
Barbara Sayuri Bellete +8 more
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Лечащий Врач, 2022 Evaluation of the effectiveness of cycloferon when used in complex therapy and for the prevention of chronic Helicobacter pyloriinduced gastritis with gastric erosions associated with Epstein – Barr virus.
T. E. Afanasenkova, E. E. Dubskaya
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, 2021 Acridone and its derivatives have potential application as emitters for highly efficient blue organic light-emitting diodes (OLEDs). In this paper, we demonstrated ultrafast access of a solvent-independent singlet–triplet equilibrium state in acridone ...
Haifeng Pan +7 more
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