Results 1 to 10 of about 10,618 (207)
3D,2D-QSAR study and docking of novel quinazolines as potential target drugs for osteosarcoma
Frontiers in Pharmacology, 2023 Background: Quinazolines are an important class of benzopyrimidine heterocyclic compounds with a promising antitumor activity that can be used for the design and development of osteosarcoma target compounds.Objective: To predict the compound activity of ...
Zheng Lian +4 more
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One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
Molecules, 2013 A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN).
Xiaodong Xia +3 more
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Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases
Scientia Pharmaceutica, 2023 Cancer is a large group of diseases that can affect any organ or body tissue due to the abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic agents are highly toxic with a low level of selectivity.
Mohamed F. Zayed
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Crystal structure of 3-amino-2-ethylquinazolin-4(3H)-one [PDF]
, 2015 The molecule of the title compound, C10H11N3O, is planar, including the ethyl group, as indicated by the N-C-C-C torsion angle of 1.5 (2)°. In the crystal, inversion-related molecules are stacked along the a axis.
Baashen, Mohammed +4 more
core +6 more sources
Hedgehog signaling pathway and its targets for treatment in basal cell carcinoma [PDF]
, 2012 Basal cell carcinoma (BCC) of the skin is the most common type of cancer, and accounts for up to 40% of all cancers in the United States with a growing incidence rate in the last decades in all developed countries.
CUCCHI, DANILO +3 more
core +3 more sources
Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
Molecules, 2010 Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinylquinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2 ...
Lucjan Strekowski +4 more
doaj +1 more source
Saudi Pharmaceutical Journal, 2023 Candida albicans, an opportunistic pathogen, is the most common type of fungus and represents a substantial source of human invasive disease (nosocomial infection).
Hatem A. Abuelizz +5 more
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Molecules, 2014 Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon–carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or ...
Malose Jack Mphahlele +1 more
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Saudi Pharmaceutical Journal, 2023 In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4–22 ...
Adel S. El-Azab +7 more
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Novel Polycarbo-Substituted Imidazo[1,2-c]quinazolines: Synthesis and Cytotoxicity Study
Molecules, 2015 Amination of the 2-aryl-6-bromo-4-chloro-8-iodoquinazolines with 2-aminoethanol followed by acid-promoted cyclodehydration of the incipient 2-((6,8-dihalo-2-phenylquinazolin-4-yl)amino)ethanols afforded the corresponding novel 5-aryl-9-bromo-7-iodo-2,3 ...
Tebogo Ankie Khoza +2 more
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