Quinazolines [a]-Annelated by Five-Membered Heterocycles: Synthesis and Biological Activity [PDF]
MoleculesThis review covers article and patent data obtained mostly within the period 2013–2024 on the synthesis and biological activity of quinazolines [a]-annelated by five-membered heterocycles.
Galina N. Lipunova +2 more
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Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances
Frontiers in Chemistry, 2021 In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies.
, Aamer Saeed, Faisal Muhammad
exaly +3 more sources
Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
Molecules, 2014 The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline ...
Malose J Mphahlele +2 more
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Research towards selective inhibition of the CLK3 kinase [PDF]
Beilstein Journal of Organic ChemistryThe cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of the mRNA splicing process. Among the four isoforms of CLKs, CLK3 is the
Vinay Kumar Singh +9 more
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Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives [PDF]
MoleculesQuinazolines are an important class of heterocyclic compounds that have proven their significance, especially in the field of organic synthesis and medicinal chemistry because of their wide range of biological and pharmacological properties.
Nitesh K. Nandwana +4 more
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Synthesis of 4-tosyl quinazoline derivatives with the assistance of ultrasound irradiation as a guide to the reaction pathway [PDF]
Scientific ReportsIn this study, we tried to show the role of ultrasonic waves in the reaction pathway of quinazolines with an amide functional group. At first, 4-tosyl quinazolines were prepared using a simple, rapid, and one-pot reaction of Cu-catalyzed cross-coupling ...
Manijeh Nematpour
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Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
Molecules, 2010 This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks.
Rashad Al-Salahi
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Synthesis and cytotoxicity studies of novel N-arylbenzo[h]quinazolin-2-amines [PDF]
Beilstein Journal of Organic ChemistryIn this paper, we report a short and efficient synthesis of novel N-arylbenzo[h]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel ...
Battini Veeraiah +8 more
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Transition-metal-catalyzed synthesis of quinazolines: A review
Frontiers in Chemistry, 2023 Quinazolines are a class of nitrogen-containing heterocyclic compounds with broad-spectrum of pharmacological activities. Transition-metal-catalyzed reactions have emerged as reliable and indispensable tools for the synthesis of pharmaceuticals.
Rekha Tamatam +4 more
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DESIGN AND SYNTHESIS OF NOVEL TERREMIDE DERIVATIVES FOR PHARMACOLOGICAL EVALUATION [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2022 clinicians and chemists are directed in those days toward the biologically active compounds to reduce the mortality and morbidity. Quinazolines were reported previously as a scaffold that possesses antitumor and antimicrobial activities. Close inspection
Mohamed Ayman +3 more
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