Quinazolines [a]-Annelated by Five-Membered Heterocycles: Synthesis and Biological Activity [PDF]
MoleculesThis review covers article and patent data obtained mostly within the period 2013–2024 on the synthesis and biological activity of quinazolines [a]-annelated by five-membered heterocycles.
Galina N. Lipunova +2 more
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Synthesis and Photophysical Property Studies of the 2,6,8-Triaryl-4-(phenylethynyl)quinazolines
Molecules, 2014 The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline ...
Malose Jack Mphahlele +2 more
exaly +4 more sources
Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
Molecules, 2010 This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks.
Rashad A Al-Salahi
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Recent Advances in the Transition-Metal-Free Synthesis of Quinazolines
Molecules, 2023 Quinazolines are a privileged class of nitrogen-containing heterocycles, widely present in a variety of natural products and synthetic chemicals with a broad spectrum of biological and medicinal activities.
Rekha Tamatam, Dongyun Shin
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Research towards selective inhibition of the CLK3 kinase [PDF]
Beilstein Journal of Organic ChemistryThe cdc2-like kinases (CLKs), are a family of kinases that attracted recently the interest of scientists due to their significant biological roles, in particular in the regulation of the mRNA splicing process. Among the four isoforms of CLKs, CLK3 is the
Vinay Kumar Singh +9 more
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Behavioural Response of Triatoma infestans (Klug) (Hemiptera: Reduviidae) to Quinazolines [PDF]
Molecules, 2005 The behavioural responses of the haematophagous bug Triatoma infestans towards some previously identified components of its faeces: 4-methylquinazoline, 2,4- dimethylquinazoline and their mixtures were evaluated using a video tracking system.
E. Zerba +7 more
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Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases
Scientia Pharmaceutica, 2023 Cancer is a large group of diseases that can affect any organ or body tissue due to the abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic agents are highly toxic with a low level of selectivity.
Mohamed F. Zayed
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Substituted pyrrolo[1,2-a][1,2,4]triazolo-(triazino-)[c]quinazolines - a promising class of lipoxygenase inhibitors [PDF]
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020 The modern strategy of potential biologically active molecules search (“drug-design”) is based on several innovation approaches. The method of high thrоughрut biological screening and method of molecular modeling deserves the most attention among such ...
V. V. Stavytskyi +5 more
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Recent Advances in Metal-Catalyzed Approaches for the Synthesis of Quinazoline Derivatives [PDF]
MoleculesQuinazolines are an important class of heterocyclic compounds that have proven their significance, especially in the field of organic synthesis and medicinal chemistry because of their wide range of biological and pharmacological properties.
Nitesh K. Nandwana +4 more
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Novel Polycarbo-Substituted Imidazo[1,2-c]quinazolines: Synthesis and Cytotoxicity Study
Molecules, 2015 Amination of the 2-aryl-6-bromo-4-chloro-8-iodoquinazolines with 2-aminoethanol followed by acid-promoted cyclodehydration of the incipient 2-((6,8-dihalo-2-phenylquinazolin-4-yl)amino)ethanols afforded the corresponding novel 5-aryl-9-bromo-7-iodo-2,3 ...
Tebogo Ankie Khoza +2 more
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