Results 11 to 20 of about 7,050 (179)

Recent Advances in the Transition-Metal-Free Synthesis of Quinazolines

Molecules, 2023
Quinazolines are a privileged class of nitrogen-containing heterocycles, widely present in a variety of natural products and synthetic chemicals with a broad spectrum of biological and medicinal activities.
Rekha Tamatam, Dongyun Shin
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Synthesis of substituted 8H-benzo[h]pyrano[2,3-f]quinazolin-8-ones via photochemical 6π-electrocyclization of pyrimidines containing an allomaltol fragment

Beilstein Journal of Organic Chemistry, 2023
For the first time, we elaborated a method for the synthesis of pyrimidines containing an allomaltol unit. The suggested approach is based on the reaction of 2-(1-(dimethylamino)-3-oxo-3-arylprop-1-en-2-yl)-3-hydroxy-6-methyl-4H-pyran-4-ones with ...
Constantine V. Milyutin, Andrey N. Komogortsev, Boris V. Lichitsky, Mikhail E. Minyaev, Valeriya G. Melekhina   +4 more
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Synthesis and Biological Evaluation of 2-Substituted Quinazolin-4(3H)-Ones with Antiproliferative Activities

Molecules, 2023
Sixteen new 2-substituted quinazolines were synthesized using a straightforward methodology starting from 2-methoxybezoic acid or 3-methoxy-2-naphthoic acid.
Maria Karelou, Dionysis Kampasis, Amalia D. Kalampaliki, Leentje Persoons, Andreas Krämer, Dominique Schols, Stefan Knapp, Steven De Jonghe, Ioannis K. Kostakis   +8 more
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Direct CH/CH functionalization of 1,3-dihydroxy-9H-xanthen-9-one and 1,3-dimethoxy-9H-xanthen-9-one with 1,2,4-triazines and quinazoline

Chimica Techno Acta, 2020
An electron-deficient series of 1,2,4-triazines and quinazoline have been used for cross-dehydrogenative coupling with 1,3-dihydroxy and 1,3-dimethoxyxanthones to give stable nucleophilic addition products.
A. D. Sharapov, R. F. Fatykhov, I. A. Khalymbadzha, O. N. Chupakhin   +3 more
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Carboxyl-containing quinazolines and related heterocycles as carriers of anti-inflammatory activity

Zaporožskij Medicinskij Žurnal, 2022
Active pharmaceutical ingredients whose structure combines aromatic or heterocyclic fragments with pharmacophore carboxylic group are widespread on pharmaceutical market.
N. I. Krasovska, V V. Stavytskyi, I. S. Nosulenko, O. Yu. Voskoboinik, S. I. Kovalenko   +4 more
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Metal-Free Synthesis of 2-Substituted Quinazolines via Green Oxidation of o-Aminobenzylamines: Practical Construction of N-Containing Heterocycles Based on a Salicylic Acid-Catalyzed Oxidation System

Frontiers in Chemistry, 2022
Conventional quinazoline synthesis methods involve a highly multistep reaction, and often require excess amounts of substrate to control the product selectivity, leading to significant resource wastage.
Yuki Yamamoto, Chihiro Yamakawa, Riku Nishimura, Chun-Ping Dong, Shintaro Kodama, Akihiro Nomoto, Michio Ueshima, Akiya Ogawa   +7 more
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Quinazoline derivatives: synthesis and bioactivities [PDF]

Chemistry Central Journal, 2013
Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations of quinazoline derivatives. According to the main method the authors adopted in their research design,
Wang, Dan, Gao, Feng
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Substituted pyrrolo[1,2-a][1,2,4]triazolo-(triazino-)[c]quinazolines - a promising class of lipoxygenase inhibitors

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020
The modern strategy of potential biologically active molecules search (“drug-design”) is based on several innovation approaches. The method of high thrоughрut biological screening and method of molecular modeling deserves the most attention among such ...
V. V. Stavytskyi, I. S. Nosulenko, O. O. Portna, V. M. Shvets, O. Yu. Voskoboynik, S. І. Kоvalenko   +5 more
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Quinazoline-containing Hydrazydes of Dicarboxylic Acids and Products of Their Structural Modification – A Novel Class of Anti-inflammatory Agents

Acta Chimica Slovenica, 2021
The synthesis of hydrazides formed by quinazolin-4(3H)-ylidenehydrazine and dicarboxylic acids, as well as their further modification are described in the present manuscript.
Nataliia Krasovska, Viktor Stavytskyi, Inna Nosulenko, Oleksandr Karpenko, Oleksii Voskoboinik, Serhii Ivanovych Kovalenko   +5 more
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DESIGN AND SYNTHESIS OF NOVEL TERREMIDE AND SULFONAIDES DERIVATIVES FOR PHARMACOLOGICAL EVALUATION [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2022
Bacterial infections were first recorded back at 3000 B.C.E. Since then, there have been an enormous number of pandemics that hit the world. Countless doctors and researchers have been working on a definitive solution to exterminate all bacterial ...
Abdelrahman Hussien, Abdelrahman Mayhoub, Mohamed Elsebaei, Ahmed Helal   +3 more
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