Results 21 to 30 of about 7,050 (179)
Analgetic Activity of a Quinazoline
Experimental Biology and Medicine, 1967 SummaryFour test systems were used to demonstrate the analgetic activity of Su-13026, a quinazoline compound, in mice, rats and rabbits. Signs of central nervous system stimulation were noted. Respiration was not depressed in any of the species studied. Nalorphine did not antagonize, nor did amphetamine potentiate, the activity of this compound in mice.
H I, Chernov +4 more
openaire +2 more sources
Beilstein Journal of Organic Chemistry, 2018 An efficient strategy for the synthesis of 6-unsubstituted indolo[1,2-c]quinazolines is described. The Pd-catalyzed reaction of o-(o-aminophenylethynyl) trifluoroacetanilides with Ar–B(OH)2 afforded 2-(o-aminophenyl)-3-arylindoles, that were converted to
Antonio Arcadi +6 more
doaj +1 more source
On the Reaction of Quinazoline with Acetophenone
Chemical and Pharmaceutical Bulletin, 1964 Carbanion reacted as nucleophilic reagent with quinazoline. Reaction of quinazoline with acetophenone in the presence of sodium hydroxide solution at room temperature afforded 2-(3, 4-dihydro-4-quinazolinyl)acetophenone. The mechanism for this reaction may be suggested as in Chart 1 in the text.
Hayashi, Eisaku, Higashino, Takeo
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Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2
Angewandte Chemie, EarlyView.By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin +3 more
wiley +2 more sources
Beilstein Journal of Organic Chemistry, 2013 Meta- or para-nitro-(pentafluorosulfonyl)benzenes underwent the Davis reaction with arylacetonitriles to provide the SF5-containing benzisoxazoles. Good yields were obtained with arylacetonitriles containing the electron-neutral or electron-donor group ...
Petr Beier, Tereza Pastýříková
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Molecules, 2015 The reactivity of the 2-aryl-4-chloro-6-iodoquinazolines towards palladium catalyzed sequential (Sonogashira/Suzuki-Miyaura) and one-pot two-step cross-coupling (bis-Sonogashira, and successive Sonogashira/Stille) reactions to afford novel unsymmetrical
Malose Jack Mphahlele +3 more
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On the Reaction of Quinazoline with Ketones
Chemical and Pharmaceutical Bulletin, 1965 The structures of the reaction products, III, IV, and V, obtained in the interaction between quinazoline and acetone, 2-butanone and cyclohexanone in the presence of hydroxide anion at room temperature, were determined to be 1-(3, 4-dihydro-4-quinazolinyl)-4-hydroxy-4-methyl-2-pentanone (III), 1-(3, 4-dihydro-4-quinazolinyl)-4-hydroxy-3, 4-dimethyl-2 ...
Hayashi, Eisaku, Higashino, Takeo
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Zaporožskij Medicinskij Žurnal, 2013 Nucleophilic degradation of 2-heteryl-[1,2,4]triazolo[1,5-c]quinazolines was investigated and the structure of {2-(3-heteryl)-1H-1,2,4-triazol-5-yl]phenyl}amines was unequivocally proved by spectral methods.
A. K. Bilyi +2 more
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One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
Molecules, 2013 A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN).
Xiaodong Xia +3 more
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Molecules, 2023 The current work was conducted to synthesize several novel anti-inflammatory quinazolines having sulfamerazine moieties as new 3CLpro, cPLA2, and sPLA2 inhibitors.
Mohammed Abdalla Hussein +5 more
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