Results 21 to 30 of about 8,749 (208)
Synthesis of 4-tosyl quinazoline derivatives with the assistance of ultrasound irradiation as a guide to the reaction pathway [PDF]
Scientific ReportsIn this study, we tried to show the role of ultrasonic waves in the reaction pathway of quinazolines with an amide functional group. At first, 4-tosyl quinazolines were prepared using a simple, rapid, and one-pot reaction of Cu-catalyzed cross-coupling ...
Manijeh Nematpour
doaj +2 more sources
A Blood-Brain Barrier-Permeable Guanylhydrazone Analogue of the ASIC3 Activator GMQ Inhibits Human Glioblastoma Stem Cell Growth In Vitro. [PDF]
ChemMedChemThe acid‐sensing ion channel 3 (ASIC3), physiologically located in the peripheral nervous system, was found in stem cells of CNS‐located glioblastoma multiforme (GBM CSCs); its chronic activation in the CNS kills dysfunctional GBM CSCs with no effect on ASIC3‐lacking CNS tissues.
Maiorana L +8 more
europepmc +2 more sources
Chemical Insights Into the Synthetic Chemistry of Quinazolines: Recent Advances
Frontiers in Chemistry, 2021 In medicinal chemistry, one of the most significant heterocyclic compounds are quinazolines, possessing broad range of biological properties such as anti-bacterial, anti-fungal, anti-HIV, anti-cancer, anti-inflammatory, and analgesic potencies.
Muhammad Faisal, Aamer Saeed
doaj +1 more source
DESIGN AND SYNTHESIS OF NOVEL TERREMIDE DERIVATIVES FOR PHARMACOLOGICAL EVALUATION [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2022 clinicians and chemists are directed in those days toward the biologically active compounds to reduce the mortality and morbidity. Quinazolines were reported previously as a scaffold that possesses antitumor and antimicrobial activities. Close inspection
Mohamed Ayman +3 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2023 For the first time, we elaborated a method for the synthesis of pyrimidines containing an allomaltol unit. The suggested approach is based on the reaction of 2-(1-(dimethylamino)-3-oxo-3-arylprop-1-en-2-yl)-3-hydroxy-6-methyl-4H-pyran-4-ones with ...
Constantine V. Milyutin +4 more
doaj +1 more source
Transition-metal-catalyzed synthesis of quinazolines: A review
Frontiers in Chemistry, 2023 Quinazolines are a class of nitrogen-containing heterocyclic compounds with broad-spectrum of pharmacological activities. Transition-metal-catalyzed reactions have emerged as reliable and indispensable tools for the synthesis of pharmaceuticals.
Rekha Tamatam +4 more
doaj +1 more source
7-Aminoalkoxy-Quinazolines from Epigenetic Focused Libraries are Potent and Selective Inhibitors of DNA Methyltransferase 1 [PDF]
, 2022 Inhibitors of epigenetic writers such as DNA methyltransferases (DNMTs) are attractive compounds for epigenetic drug and probe discovery. There are many small molecules tested as inhibitors of DNMTs but, overall, they do not have potent enzymatic ...
Edgar, López-López +2 more
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Molecules, 2023 Sixteen new 2-substituted quinazolines were synthesized using a straightforward methodology starting from 2-methoxybezoic acid or 3-methoxy-2-naphthoic acid.
Maria Karelou +8 more
doaj +1 more source
Convenient Synthetic Approach to 2,4-Disubstituted Quinazolines
, 2016 2,4-Dialkyl or aryl quinazolines have been prepared in three steps starting from easily available anilides. A photochemically induced Fries rearrangement of the anilides gave several ortho-aminoacylbenzene derivatives that were acylated at the NH2. These
Serena Ferrini (1642930) +2 more
core +3 more sources
Studies of novel nitro-substituted nitrogen heterocyclic compounds [PDF]
, 2001 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The novel candidate high energy insensitive explosive; 2,5-diamino-3,6-dinitropyrazine (ANPZ-i) has been prepared in acceptable overall yield.
Philbin, Simon Patrick
core +6 more sources