Results 41 to 50 of about 8,749 (208)
Zaporožskij Medicinskij Žurnal, 2013 Nucleophilic degradation of 2-heteryl-[1,2,4]triazolo[1,5-c]quinazolines was investigated and the structure of {2-(3-heteryl)-1H-1,2,4-triazol-5-yl]phenyl}amines was unequivocally proved by spectral methods.
A. K. Bilyi +2 more
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One-Pot Tandem Synthesis of 2-Arylquinazolines by a Multicomponent Cyclization Reaction
Molecules, 2013 A series of 2-arylquinazolines have been synthesized in moderate to excellent yields by one-pot tandem reaction of (2-aminophenyl)methanols, aldehydes and ceric ammonium nitrate (CAN).
Xiaodong Xia +3 more
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Molecules, 2023 The current work was conducted to synthesize several novel anti-inflammatory quinazolines having sulfamerazine moieties as new 3CLpro, cPLA2, and sPLA2 inhibitors.
Mohammed Abdalla Hussein +5 more
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3D,2D-QSAR study and docking of novel quinazolines as potential target drugs for osteosarcoma
Frontiers in Pharmacology, 2023 Background: Quinazolines are an important class of benzopyrimidine heterocyclic compounds with a promising antitumor activity that can be used for the design and development of osteosarcoma target compounds.Objective: To predict the compound activity of ...
Zheng Lian +4 more
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Simple and straight forward synthesis of 2,4-disubstituted quinazolines in aqueous medium [PDF]
, 2012 Efficient synthesis of diverse quinazolines from readily available starting materials was achieved in aqueous medium via one-pot protocol. A number of 2,4-disubstituted quinazolines were prepared in moderate to good yields under mild and catalyst-free ...
Bandaru, Madhav +4 more
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Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer
, 2021 The efficacy of quinazoline-based antiglioma agents has been attributed to their effects on microtubule dynamics. The design, synthesis and biological evaluation of quinazolines as potent inhibitors of multiple intracellular targets, including ...
Hamel, Ernest +6 more
core +1 more source
Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
Molecules, 2010 Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinylquinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2 ...
Lucjan Strekowski +4 more
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Convenient synthetic approach to 2,4-disubstituted quinazolines
, 2007 2,4-Dialkyl or aryl quinazolines have been prepared in three steps starting from easily available anilides. A photochemically induced Fries rearrangement of the anilides gave several ortho-aminoacylbenzene derivatives that were acylated at the NH2. These
Maurizio Taddei +5 more
core +1 more source
Molecules, 2014 Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon–carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or ...
Malose Jack Mphahlele +1 more
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