Results 51 to 60 of about 8,749 (208)

Benzo[g]quinazolines as antifungal against candidiasis: Screening, molecular docking, and QSAR investigations

Saudi Pharmaceutical Journal, 2023
Candida albicans, an opportunistic pathogen, is the most common type of fungus and represents a substantial source of human invasive disease (nosocomial infection).
Hatem A. Abuelizz, Ahmed H. Bakheit, Mohamed H. Al-Agamy, Harunor Rashid, Gamal A.E. Mostafa, Rashad Al-Salahi   +5 more
doaj   +1 more source

Design, synthesis, and carbonic anhydrase inhibition activities of Schiff bases incorporating benzenesulfonamide scaffold: Molecular docking application

Saudi Pharmaceutical Journal, 2023
In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4–22 ...
Adel S. El-Azab, Alaa A.-M. Abdel-Aziz, Silvia Bua, Alessio Nocentini, Ahmed H. Bakheit, Hamad M. Alkahtani, Mohamed M. Hefnawy, Claudiu T. Supuran   +7 more
doaj   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

16.13.5 Quinazolines (Update 2015)

, 2016
This chapter is an update to the earlier Science of Synthesis contribution (Section 16.13) describing methods for the synthesis of quinazolines. It summarizes new technologies and surveys the literature published in the period 2002–2012.
S.-M. Yang, F.-A. Kang
core   +1 more source

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES. [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2015
In this study, novel 3-substituted 1,2,4-triazino[6,1-b]quinazolines 4a-e, 8-substituted-1H-[1,2,4]triazino[6,1-b]quinazoline-2,4,10(3H)-triones 8a&b  and 2-substituted 1,2,4-triazino[6,1-b]quinazolines 9a-d, 10 & 11 were synthesized from 3-amino-
Mervat El-Enany
doaj   +1 more source

Synthesis, Antibacterial, and Antioxidant Evaluation of Novel Series of Condensed Thiazoloquinazoline with Pyrido, Pyrano, and Benzol Moieties as Five- and Six-Membered Heterocycle Derivatives

Molecules, 2021
A novel synthesis of thiazolo[2,3-b]quinazolines 4(a–e), pyrido[2′,3′:4,5]thiazolo[2,3-b]quinazolines {5(a–e), 6(a–e), and 7(a–e)}, pyrano[2′,3′:4,5]thiazolo[2,3-b]quinazolines 8(a–e), and benzo[4,5]thiazolo[2,3-b]quinazoloine9(a–e) derivatives starting ...
Ebraheem Abdu Musad Saleh, Abdullah Mohammed AL Dawsari, Kakul Husain, Ismail Hassan Kutty, K.M.Lokanatha Rai   +4 more
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Quinazolines by electrocyclic ring closure of 1,3-diaza-1,3-dienes

, 1990
N-imidoyliminotripheny]phosphorane reacts with aliphatic and aromatic aldehydes to give via an 1,3-diaza-1,3-diene intermediate 3,4-dihydro quinazolines and quinazolines.
G. Celentano, Alberto Strada, E. Rossi, A. Strada, R. Stradi, Riccardo Stradi, Elisabetta Rossi, Giuseppe Celentano   +7 more
core   +1 more source

The MoSR‐MoDde1 Regulatory Axis: A Novel Determinant of DMI Sensitivity and a Target for Sustainable Rice Blast Control

Advanced Science, EarlyView.
The transcription factor MoSR governs DMI fungicide sensitivity in Magnaporthe oryzae through dual regulation of ergosterol biosynthesis and the detoxification enzyme MoDde1. Targeting MoDde1 via a small‐molecule inhibitor or host‐induced gene silencing enhances DMI efficacy against rice blast, offering a sustainable disease management strategy ...
Fan‐Zhu Meng, Wen‐Kai Wei, Meng‐Yao Wu, Min‐Zheng Cai, Yu‐Fu Wang, Li Zhao, Shuai Meng, Liang‐Fen Yin, Guido Schnabel, Wei‐Xiao Yin, Chao‐Xi Luo   +10 more
wiley   +1 more source

A new access to quinazolines from simple anilines

, 2006
A new synthetic pathway to quinazolines is described. This new method uses hexamethylenetetramine in TFA and potassium ferricyanide in aqueous ethanolic KOH, starting from simple N-protected anilines. The method affords substituted quinazolines with high
Marzaro, G., Manzini, P., ZANATTA, SAMUELE, PASTORINI G, BARBIERI, VERA, GUIOTTO, ADRIANO, CHILIN, ADRIANA, Zanatta, S., MARZARO, GIOVANNI, Guiotto, A., MANZINI, PAOLO, Pastorini, G., Barbieri, V., Chilin, A.   +13 more
core   +1 more source