Results 31 to 40 of about 7,050 (179)
3D,2D-QSAR study and docking of novel quinazolines as potential target drugs for osteosarcoma
Frontiers in Pharmacology, 2023 Background: Quinazolines are an important class of benzopyrimidine heterocyclic compounds with a promising antitumor activity that can be used for the design and development of osteosarcoma target compounds.Objective: To predict the compound activity of ...
Zheng Lian +4 more
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Novel Polycarbo-Substituted Imidazo[1,2-c]quinazolines: Synthesis and Cytotoxicity Study
Molecules, 2015 Amination of the 2-aryl-6-bromo-4-chloro-8-iodoquinazolines with 2-aminoethanol followed by acid-promoted cyclodehydration of the incipient 2-((6,8-dihalo-2-phenylquinazolin-4-yl)amino)ethanols afforded the corresponding novel 5-aryl-9-bromo-7-iodo-2,3 ...
Tebogo Ankie Khoza +2 more
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Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases
Scientia Pharmaceutica, 2023 Cancer is a large group of diseases that can affect any organ or body tissue due to the abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic agents are highly toxic with a low level of selectivity.
Mohamed F. Zayed
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Conjugate Addition of Nucleophiles to the Vinyl Function of 2-Chloro-4-vinylpyrimidine Derivatives
Molecules, 2010 Conjugate addition reaction of various nucleophiles across the vinyl group of 2-chloro-4-vinylpyrimidine, 2-chloro-4-(1-phenylvinyl)pyrimidine and 2-chloro-4-vinylquinazoline provides the corresponding 2-chloro-4-(2-substituted ethyl)pyrimidines and 2 ...
Lucjan Strekowski +4 more
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Molecules, 2014 Halogenated quinazolinones and quinazolines are versatile synthetic intermediates for the metal-catalyzed carbon–carbon bond formation reactions such as the Kumada, Stille, Negishi, Sonogashira, Suzuki-Miyaura and Heck cross-coupling reactions or ...
Malose Jack Mphahlele +1 more
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Saudi Pharmaceutical Journal, 2023 Candida albicans, an opportunistic pathogen, is the most common type of fungus and represents a substantial source of human invasive disease (nosocomial infection).
Hatem A. Abuelizz +5 more
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Saudi Pharmaceutical Journal, 2023 In this study, The inhibitory actions of human carbonic anhydrase (CA, EC 4.2.1.1) (hCA) isoforms I, II, IX, and XII are being examined using recently synthesized substituted hydroxyl Schiff derivatives based on the quinazoline scaffold 4–22 ...
Adel S. El-Azab +7 more
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An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity
Advanced Science, EarlyView.The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao +9 more
wiley +1 more source
SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME NEW 1,2,4-TRIAZINO[6,1-B]QUINAZOLINE DERIVATIVES. [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2015 In this study, novel 3-substituted 1,2,4-triazino[6,1-b]quinazolines 4a-e, 8-substituted-1H-[1,2,4]triazino[6,1-b]quinazoline-2,4,10(3H)-triones 8a&b and 2-substituted 1,2,4-triazino[6,1-b]quinazolines 9a-d, 10 & 11 were synthesized from 3-amino-
Mervat El-Enany
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Molecules, 2021 A novel synthesis of thiazolo[2,3-b]quinazolines 4(a–e), pyrido[2′,3′:4,5]thiazolo[2,3-b]quinazolines {5(a–e), 6(a–e), and 7(a–e)}, pyrano[2′,3′:4,5]thiazolo[2,3-b]quinazolines 8(a–e), and benzo[4,5]thiazolo[2,3-b]quinazoloine9(a–e) derivatives starting ...
Ebraheem Abdu Musad Saleh +4 more
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