Multi-Kinase Inhibition by New Quinazoline–Isatin Hybrids: Design, Synthesis, Biological Evaluation and Mechanistic Studies [PDF]
PharmaceuticalsBackground/Objectives: Cancer is a worldwide health concern and is the second leading cause of death, responsible for nearly one in six deaths. Discovery of new anticancer agents is still a challenge for medicinal chemists and further research will ...
Mohammed M. Alanazi, Reem I. Al-Wabli
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EXPLORING THE PROTEIN KINASE INHIBITORY ACTIVITY OF QUINAZOLINES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2023 Due to its powerful anticancer characteristics, the heterocyclic quinazoline has attracted a lot of interest in cancer research. Several cancer types, including lung, breast, colon, ovarian, and prostate cancers, have shown promise in response to ...
Abdelsalam Ouf +3 more
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COMPUTATION DESIGN OF QUINAZOLINE-4(3H)-ON DERIVATIVES AS CYCLOOXYGENASE-2 (COX-2) INHIBITOR
Jurnal Farmasi Sains dan Praktis, 2021 The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted ...
Anita Puspa Widiyana
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Антибиотики и Химиотерапия, 2023 The study is devoted to the study of acute toxicity of a new quinazoline compound — 3-[2-Oxo-2-(4-phenylpiperazine-1-yl)ethyl]quinazoline-4(3H)-one (VMA-10-21), promising as an antimicrobial agent active against opportunistic microorganisms.
N. M. Gabitova +3 more
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A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
Molecules, 2022 The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives.
Malose J. Mphahlele
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DESIGN AND SYNTHESIS OF NOVEL TERREMIDE AND SULFONAIDES DERIVATIVES FOR PHARMACOLOGICAL EVALUATION [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2022 Bacterial infections were first recorded back at 3000 B.C.E. Since then, there have been an enormous number of pandemics that hit the world. Countless doctors and researchers have been working on a definitive solution to exterminate all bacterial ...
Abdelrahman Hussien +3 more
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Design and Molecular Docking Studies of Quinazoline Derivatives as Antiproliferation
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2018 Background: Nowadays, a lot of new active substances as anticancer agents have been developed. One of the protein targets of anticancer is selective cyclooxygenase-2 (COX-2). Selective COX-2 is the regulator of cell proliferation.
Anita Puspa Widiyana +4 more
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New pathways for the synthesis of indolyl-containing quinazoline trifluoroacetohydrazides
Chimica Techno Acta, 2020 The reactions of indole-3-carbaldehyde arylhydrazones with quinazoline in TFA proceed at the 7' position of the aryl part of the hydrazone molecule to form σ-adducts of quinazoline trifluoroacetohydrazides.
Yu. A. Azev +4 more
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Synthesis Of Some Substituted 1,2,5-Oxadiazino [2-3,b] Quinazoline And Some 1,3-Oxazole Derivatives [PDF]
مجلة التربية والعلم, 2013 In this paper the synthesis of some 1,2,5- oxadiazino [2-3,b] quinazoline and some substituted 1,3- oxazole are reported, alanine and valine were reacted with benzoyle chloride in sodium hydroxide solution to give N- benzoyle alanine or valine (1,2 ...
Yassir S. Mohamad
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Crystal structure of 4-methylsulfanyl-2-phenylquinazoline
Acta Crystallographica Section E, 2014 In the title compound, C15H12N2S, the methylthioquinazoline group is planar with the methyl C displaced by only 0.116 (3) Å from the plane of the quinazoline moiety. The dihedral angle between the phenyl ring and the quinazoline ring system is 13.95 (5)°.
Mohammed B. Alshammari +4 more
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