Results in ChemistryThe rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures.
Vishwanath Halappanavar +3 more
exaly +4 more sources
Design and Molecular Docking Studies of Quinazoline Derivatives as Antiproliferation
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2018 Background: Nowadays, a lot of new active substances as anticancer agents have been developed. One of the protein targets of anticancer is selective cyclooxygenase-2 (COX-2). Selective COX-2 is the regulator of cell proliferation.
Anita Puspa Widiyana +4 more
doaj +2 more sources
Design, Synthesis, and Biological Activity Evaluation of Quinazoline-Based PLK4 Inhibitors [PDF]
BiomedicinesBackground: As a key regulator of centrosome duplication, polo-like kinase 4 (PLK4) is abnormally overexpressed in various tumors and has emerged as an important target for the development of antitumor drugs.
Wenqiang Sun +10 more
doaj +2 more sources
Design, Synthesis and Anticancer Evaluation of Novel Quinazoline-Sulfonamide Hybrids
Molecules, 2016 By combining the structural features of quinazoline and sulfonamides, novel hybrid compounds 2–21 were synthesized using a simple and convenient method.
Marwa El-Gazzar +2 more
exaly +3 more sources
Molecular Dynamics–Based validation of a quinazoline-based KRAS inhibitor (C9) identified through QSAR-guided discovery [PDF]
Frontiers in BioinformaticsBackgroundKRAS remains one of the most challenging oncogenic targets in lung cancer because of its shallow binding surfaces, conformational flexibility, and limited availability of druggable pockets.
Stephen Adebayo Osasan +8 more
doaj +2 more sources
EXPLORING THE PROTEIN KINASE INHIBITORY ACTIVITY OF QUINAZOLINES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2023 Due to its powerful anticancer characteristics, the heterocyclic quinazoline has attracted a lot of interest in cancer research. Several cancer types, including lung, breast, colon, ovarian, and prostate cancers, have shown promise in response to ...
Abdelsalam Ouf +3 more
doaj +1 more source
COMPUTATION DESIGN OF QUINAZOLINE-4(3H)-ON DERIVATIVES AS CYCLOOXYGENASE-2 (COX-2) INHIBITOR
Jurnal Farmasi Sains dan Praktis, 2021 The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted ...
Anita Puspa Widiyana
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Антибиотики и Химиотерапия, 2023 The study is devoted to the study of acute toxicity of a new quinazoline compound — 3-[2-Oxo-2-(4-phenylpiperazine-1-yl)ethyl]quinazoline-4(3H)-one (VMA-10-21), promising as an antimicrobial agent active against opportunistic microorganisms.
N. M. Gabitova +3 more
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A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
Molecules, 2022 The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives.
Malose J. Mphahlele
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Medicinal Chemistry of Quinazolines as Analgesic and Anti-Inflammatory Agents
ChemEngineering, 2022 Quinazoline is an essential scaffold, known to be linked with various biological activities. Some of the prominent biological activities of this system are analgesic, anti-inflammatory, anti-hypertensive, anti-bacterial, anti-diabetic, anti-malarial ...
Mohamed F. Zayed
doaj +1 more source