Results 1 to 10 of about 24,919 (239)

Quinazoline pharmacophore in therapeutic medicine [PDF]

Bangladesh Journal of Pharmacology, 2016
This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic ...
Olayinka Oyewale Ajani, Damilola Victoria Aderohunmu, Ejike Nzube Umeokoro, Ayodele Ojo Olomieja   +3 more
doaj   +3 more sources

Multi-Kinase Inhibition by New Quinazoline–Isatin Hybrids: Design, Synthesis, Biological Evaluation and Mechanistic Studies [PDF]

Pharmaceuticals
Background/Objectives: Cancer is a worldwide health concern and is the second leading cause of death, responsible for nearly one in six deaths. Discovery of new anticancer agents is still a challenge for medicinal chemists and further research will ...
Mohammed M. Alanazi, Reem I. Al-Wabli
doaj   +2 more sources

Rational Design and Synthesis of a Novel Series of Thiosemicarbazone-Containing Quinazoline Derivatives as Potential VEGFR2 Inhibitors [PDF]

Pharmaceutics
Background/Objectives: Angiogenesis plays a crucial role in tumor development and is a driving force for the aggressiveness of several types of cancer. Our team developed a novel series of thiosemicarbazone-containing quinazoline derivatives, TSC1-TSC10,
Alexandru Șandor, Ovidiu Crișan, Gabriel Marc, Ionel Fizeșan, Ioana Ionuț, Cristina Moldovan, Anca Stana, Ilioara Oniga, Adrian Pîrnău, Laurian Vlase, Andreea-Elena Petru, Ionuț-Valentin Creștin, Alex-Robert Jîjie, Brîndușa Tiperciuc, Ovidiu Oniga   +14 more
doaj   +2 more sources

Multicomponent Synthesis of Multi-Target Quinazolines Modulating Cholinesterase, Oxidative Stress, and Amyloid Aggregation Activities for the Therapy of Alzheimer’s Disease [PDF]

Molecules
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder characterized by extracellular accumulation of amyloid-beta (Aβ) peptide, intracellular neurofibrillary tangles (NFTs), severe neuronal loss, and a marked decline in cholinergic ...
Saida Chakhari, José Marco-Contelles, Isabel Iriepa, Maria do Carmo Carreiras, Fakher Chabchoub, Lhassane Ismaili, Bernard Refouvelet   +6 more
doaj   +2 more sources

Synthesis and Anticancer Evaluation of Some Glycine Conjugated Hybrid Compounds Containing Coumarin, Thiophene and Quinazoline Moieties [PDF]

Pharmaceuticals
Background/Objectives: Cancer is one of the world’s leading causes of death. In 2022 alone, 9.74 million people died of cancer. It is estimated that this figure will rise to 10.4 million by 2025.
Nedime Çalışkan, Emre Menteşe, Fatih Yılmaz, Süleyman İlhan, Mustafa Emirik   +4 more
doaj   +2 more sources

COMPUTATION DESIGN OF QUINAZOLINE-4(3H)-ON DERIVATIVES AS CYCLOOXYGENASE-2 (COX-2) INHIBITOR

Jurnal Farmasi Sains dan Praktis, 2021
The 3-(benzylideneamino)-2-(2,4-dichlorophenyl)-quinazoline-4(3H)-ones (BDCQ) are compounds developed as anticancer drugs and quinazolines. The activity and bioavailability of BDCQ derivatives as anticancer compounds that inhibit COX-2 can be predicted ...
Anita Puspa Widiyana
doaj   +1 more source

Assessment of Acute Toxicity of Quinazoline Derivative 3-[2-oxo-2-(4-Phenylpiperazine-1-yl)Ethyl]quinazoline-4(3h)-oh Active against Opportunistic Microorganisms

Антибиотики и Химиотерапия, 2023
The study is devoted to the study of acute toxicity of a new quinazoline compound — 3-[2-Oxo-2-(4-phenylpiperazine-1-yl)ethyl]quinazoline-4(3H)-one (VMA-10-21), promising as an antimicrobial agent active against opportunistic microorganisms.
N. M. Gabitova, A. A. Tsibizova, A. A. Ozerov, M. A. Samotrueva   +3 more
doaj   +1 more source

A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides

Molecules, 2022
The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives.
Malose J. Mphahlele
doaj   +1 more source

Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease. [PDF]

Sci Transl Med
Tulloch LB, Tawell H, Taylor AE, Lima ML, Dawson A, Carvalho S, Wall RJ, Corpas-Lopez V, Dey G, Duggan J, Magalhaes LG, Torrie LS, Frame L, Robinson D, Patterson S, Tinti M, Weaver GW, Robinson WJ, Cal M, Kaiser M, Mäser P, Sjö P, Perry B, Kelly JM, Francisco AF, Bhambra AS, Wyllie S.   +26 more
europepmc   +3 more sources

New pathways for the synthesis of indolyl-containing quinazoline trifluoroacetohydrazides

Chimica Techno Acta, 2020
The reactions of indole-3-carbaldehyde arylhydrazones with quinazoline in TFA proceed at the 7' position of the aryl part of the hydrazone molecule to form σ-adducts of quinazoline trifluoroacetohydrazides.
Yu. A. Azev, O. S. Koptyaeva, O. S. Eltsov, Yu. A. Yakovleva, T. A. Pospelova   +4 more
doaj   +1 more source