Quinazoline Derivatives as Potential Therapeutic Agents in Urinary Bladder Cancer Therapy [PDF]
Frontiers in Chemistry, 2021 Cancer diseases remain major health problems in the world despite significant developments in diagnostic methods and medications. Many of the conventional therapies, however, have limitations due to multidrug resistance or severe side effects.
Paulina Wdowiak +5 more
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Design, Synthesis, Molecular Dynamics, and In Vitro Evaluation of Isatin-Based Quinazoline Derivatives as Potential Antidiabetic Agents. [PDF]
Chem BiodiversA series of substituted indolo[2,1‐b]quinazoline‐6,12‐diones (SJ1‐SJ8) has been studied for their possible α‐amylase inhibition property as an antidiabetic lead compound. The most potent inhibitory activity among the tested derivatives was showed by SJ2 (IC50 = 18.49 ± 0.06 µM), similar to the reference drug acarbose (IC50 = 16.26 ± 0.02 µM).
Jaidka S +4 more
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New quinazoline derivatives with anti-inflammatory activity and computationally predicted PDE7A binding: synthesis, molecular modeling, and in silico pharmacokinetic evaluation [PDF]
Frontiers in PharmacologyQuinazoline scaffolds are widely recognized in drug discovery for their diverse pharmacological profiles, and several quinazoline derivatives have been reported as phosphodiesterase 7A (PDE7A) inhibitors with potential anti-inflammatory effects.
Majed Alharbi +6 more
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Discovery of cytotoxic indolo[1,2-c]quinazoline derivatives through scaffold-based design [PDF]
Beilstein Journal of Organic ChemistryIndolo[1,2-c]quinazoline derivatives have emerged as promising chemotype in drug discovery due to their versatile biological activities, including antimicrobial and antiviral properties.
Daniil V. Khabarov +5 more
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Results in ChemistryThe rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures.
Vishwanath Halappanavar +3 more
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International Journal of Electrochemical Science, 2013 The inhibiting effect of some quinazoline derivatives on the corrosion of carbon steel in 2 M HCl was studied by weight loss, potentiodynamic polarization, electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM) and energy ...
A.S. Fouda +2 more
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Molecules, 2014 A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good ...
Guangjin Yu +3 more
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EXPLORING THE PROTEIN KINASE INHIBITORY ACTIVITY OF QUINAZOLINES AS ANTICANCER AGENTS: FDA-APPROVED DRUGS AND PROMISING REPORTED COMPOUNDS [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2023 Due to its powerful anticancer characteristics, the heterocyclic quinazoline has attracted a lot of interest in cancer research. Several cancer types, including lung, breast, colon, ovarian, and prostate cancers, have shown promise in response to ...
Abdelsalam Ouf +3 more
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A Review on the Synthesis and Chemical Transformation of Quinazoline 3-Oxides
Molecules, 2022 The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives.
Malose J. Mphahlele
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Computational investigation of quinazoline derivatives as Keap1 inhibitors for Alzheimer's disease
Informatics in Medicine Unlocked, 2023 The Keap1-Nrf2-ARE pathway is crucial in the antioxidant defense mechanism. The Keap1-Nrf2-ARE pathway has become an important target for the development of potent therapeutic agents for numerous diseases.
Sharmila Gote +4 more
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