Results 31 to 40 of about 387 (133)

Medicinal Chemistry of Quinazolines as Analgesic and Anti-Inflammatory Agents

ChemEngineering, 2022
Quinazoline is an essential scaffold, known to be linked with various biological activities. Some of the prominent biological activities of this system are analgesic, anti-inflammatory, anti-hypertensive, anti-bacterial, anti-diabetic, anti-malarial ...
Mohamed F. Zayed
doaj   +1 more source

An Integrated DNA Nanoprobe for Intranuclear Imaging and in Situ Profiling of OGG1 Activity

Advanced Science, EarlyView.
The TP‐SA nanoprobe, integrating an AS1411 aptamer for nuclear delivery and a FRET array for signal amplification, enables real‐time tracking of nuclear OGG1 activity. It reveals cell‐line‐specific basal OGG1 levels and shows clinical promise using pneumonia patients’ lavage fluid.
Mingzhu Zhao, Xuemei Sun, He Li, Bangming Wang, Mengting Pan, Zhen Ma, Rong‐Mei Kong, Weiheng Kong, Yan Zhao, Fengli Qu   +9 more
wiley   +1 more source

Heterocyclic compounds with diverse biological activities: A review of quinazoline and quinazolinone derivatives

Results in Chemistry
Quinazoline and its derivative quinazolinone represent a vital class of nitrogen-containing heterocyclic compounds known for their diverse and potent biological activities.
Aditi Kalakwade, Rohini S. Kavalapure, Shankar Gharge, Shankar G. Alegaon, Shriram D. Ranade, Ling Shing Wong, Ramith Ramu   +6 more
doaj   +1 more source

Synthesis and anticancer activity of new quinazoline derivatives

Saudi Pharmaceutical Journal, 2017
In this study, a new series of quinazoline derivatives (3-26) was synthesized and characterized via physicochemical and spectral means. Treatment of 2-amino-5-methylbenzoic acid with butyl isothiocyanate resulted in the new 2-thioxoquinazolin-4-one (3).
Hatem A. Abuelizz, Mohamed Marzouk, Hazem Ghabbour, Rashad Al-Salahi   +3 more
openaire   +3 more sources

Reactions of organolithium reagents with quinazoline derivatives [PDF]

Arkivoc, 2012
This review deals with directed and regioselective lithiation of various quinazoline derivatives by the use of alkyllithiums in anhydrous THF at low temperature. Reactions of the lithium reagents obtained from the lithiation reactions with a range of electrophiles give the corresponding substituted derivatives in high yields. The procedures are simple,
Gamal A. El-Hiti, Amany S. Hegazy, Mohammad Hayal Alotaibi, Mansour D. Ajarim   +3 more
openaire   +1 more source

Low‐Temperature in Situ Upgrading of Ultra‐Deep Heavy Oil Using Ni–Ce/MOF–OTf Superacid Catalysts to Enhance Energy Utilization and Sustainability

EcoEnergy, EarlyView.
A triflate‐functionalized Ni–Ce/MOF–OTf superacid enables low‐temperature (∼140°C) in situ upgrading of ultra‐deep heavy oil. It reduces viscosity by 92.11% in 12 h, maintains activity over cycles, and delivers 90.25% recovery with a lower carbon footprint by selective bond cleavage. ABSTRACT Ultra‐deep heavy oil is an important unconventional resource,
Li Wang, Ji‐Xiang Guo, Qiming Huang, Kunpeng Li, Chi Li, Yajie Wu   +5 more
wiley   +1 more source

Comparative Analysis of Molecular Docking Programs GOLD, Glide, and MOE on Quinazoline Derivatives as Antiproliferative Agents: Implications for EGFR-Targeted Therapies

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Background: To aid in the identification of drug candidates and the prediction of protein-ligand interactions, molecular docking predicts how ligands interact with receptors, aiding drug discovery.
Ali Hussein Sabr, Monther Faisal Mahdi, Talal Aburjai   +2 more
doaj   +1 more source

Mesityl‐Substituted Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxalines: Synthesis, Functionalization, Photophysical, and Electrochemical Properties

European Journal of Organic Chemistry, EarlyView.
Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxaline with a mesityl group as a solubilizing group was synthesized. By synthesizing derivatives in which various functional groups were introduced into two electronically distinct sites, the pyrrole nitrogen atom and the azulene five‐membered ring, we were able to reveal that the photophysical and electrochemical ...
Ryuta Sekiguchi, Hiroki Mizuno, Ikumi Uchiyama, Souta Yuruka, Atsuya Shimizu, Taku Shoji, Shunji Ito   +6 more
wiley   +1 more source

Synthesis of some novel dibromo-2-arylquinazolinone derivatives as cytotoxic agents

Research in Pharmaceutical Sciences, 2019
Recently the quinazoline derivatives have attracted much attention for their anticancer properties. In this study a series of new brominated quinazoline derivatives (1a-1g) were synthesized in two steps.
Zeinab Faghih, Nasrin Rahmannejadi, Razieh Sabet, Kamiar Zomorodian, Mohammad Asad, Soghra Khabnadideh   +5 more
doaj   +1 more source

Discovery of Quinazoline-2,4(1H,3H)-Dione Derivatives as Potential Antibacterial Agent: Design, Synthesis, and Their Antibacterial Activity

Molecules, 2022
In this paper, we report on the design and synthesis of a novel series of quinazoline-2,4(1H,3H)-dione derivatives as fluoroquinolone-like inhibitors of bacterial gyrase and DNA topoisomerase IV to identify and develop antimicrobial agents to prevent ...
Nader M. Boshta, Farag A. El-Essawy, Mohammed B. Alshammari, Safaa G. Noreldein, Osama M. Darwesh   +4 more
doaj   +1 more source