Results 31 to 40 of about 623,955 (160)

Quinazoline derivatives: synthesis and bioactivities

, 2013
Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations ...
Wang, Dan, Feng Gao, Gao, Feng, Dan Wang
core   +1 more source

A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline

Beilstein Journal of Organic Chemistry, 2014
A convenient CuI/L-proline-catalyzed, two-step one-pot method has been developed for the preparation of indolo[1,2-a]quinazoline derivatives using a sequential Ullmann-type C–C and C–N coupling.
Chunpu Li, Lei Zhang, Shuangjie Shu, Hong Liu   +3 more
doaj   +1 more source

Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms

Biomolecules
Quinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs.
Zhijiang Deng, Jieming Li, Pengbo Zhu, Jie Wang, Yuanfang Kong, Yulong Hu, Juntao Cai, Chunhong Dong   +7 more
doaj   +1 more source

Hybrid molecules derived from quinazoline and 1,2,3-triazoles: synthesis and antibacterial activity evaluation

Results in Chemistry
In this study, the synthesis of novel hybrid molecules derived from quinazoline and 1,2,3-triazoles was reported via copper-catalyzed click reaction. The reaction of quinazoline-4-one-2-thione and quinazoline-2,4-dione with 3-bromoprop-1-yne produced ...
Mahnaz Hashemipour, Ali Keivanloo, Mohammad Bakherad, Hossein Aghamollaei   +3 more
doaj   +1 more source

Prediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression method. [PDF]

PLoS ONE, 2011
The epidermal growth factor receptor (EGFR) protein tyrosine kinase (PTK) is an important protein target for anti-tumor drug discovery. To identify potential EGFR inhibitors, we conducted a quantitative structure-activity relationship (QSAR) study on the
Hongying Du, Zhide Hu, Andrea Bazzoli, Yang Zhang   +3 more
doaj   +1 more source

Preparation of chiral quinazoline derivatives [PDF]

, 2015
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Lukáš Górecki Consultant: prof. RNDr. Milan Pour, Ph.D.
Górecki, Lukáš
core   +1 more source

Loss of E3 Ubiquitin Ligase RINES via CpG Methylation Relieves Suppression of STAT3 and MYC, Facilitating Multiple Tumorigeneses

Advanced Science, EarlyView.
Dysregulated protein modifications drive tumorigenesis. RINES, an E3 ubiquitin ligase, represses tumor cell proliferation and metastasis by facilitating RING domain‐dependent, ubiquitin–proteasome‐mediated degradation of STAT3 and MYC, which consequently restrains cancer stemness and oncogenic progression.
Lili Li, Ka Man Ng, Xingsheng Shu, Xiaoxue Chai, Kai Yau Wong, Gopesh Srivastava, Anthony T.C. Chan, Wai Yee Chan, Qian Tao   +8 more
wiley   +1 more source

Heterocyclic compounds with diverse biological activities: A review of quinazoline and quinazolinone derivatives

Results in Chemistry
Quinazoline and its derivative quinazolinone represent a vital class of nitrogen-containing heterocyclic compounds known for their diverse and potent biological activities.
Aditi Kalakwade, Rohini S. Kavalapure, Shankar Gharge, Shankar G. Alegaon, Shriram D. Ranade, Ling Shing Wong, Ramith Ramu   +6 more
doaj   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

Medicinal Chemistry of Quinazolines as Analgesic and Anti-Inflammatory Agents

ChemEngineering, 2022
Quinazoline is an essential scaffold, known to be linked with various biological activities. Some of the prominent biological activities of this system are analgesic, anti-inflammatory, anti-hypertensive, anti-bacterial, anti-diabetic, anti-malarial ...
Mohamed F. Zayed
doaj   +1 more source