Results 11 to 20 of about 387 (133)

Design and Molecular Docking Studies of Quinazoline Derivatives as Antiproliferation

Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2018
Background: Nowadays, a lot of new active substances as anticancer agents have been developed. One of the protein targets of anticancer is selective cyclooxygenase-2 (COX-2). Selective COX-2 is the regulator of cell proliferation.
Anita Puspa Widiyana, Galih Satrio Putra, Luthfi Ahmad Muchlashi, Mellany Ika Sulistyowaty, Tutuk Budiati   +4 more
doaj   +1 more source

Some novel hybrid quinazoline-based heterocycles as potent cytotoxic agents

Research in Pharmaceutical Sciences, 2022
Background and purpose: In this study, some new cytotoxic hybrid structures were synthesized by combining pyrazolinone and imidazolinone rings with quinazoline pharmacophores. Experimental approach: The benzoxazinone, pyrazolo-quinazoline fused ring, and
Mahla Malekzadeh, Shadi Dadkhah, Ghadam Ali Khodarahmi, Parvin Asadi, Farshid Hassanzadeh, Mahboubeh Rostami   +5 more
doaj   +1 more source

Quinazoline analogues as cytotoxic agents; QSAR, docking, and in silico studies

Research in Pharmaceutical Sciences, 2021
Background and purpose: Synthesis and investigation of pharmacological activity of novel compounds are time and money-consuming. However, computational techniques, docking, and in silico studies have facilitated drug discovery research to design ...
Leila Emami, Razieh Sabet, Soghra Khabnadideh, Zeinab Faghih, Parvin Thayori   +4 more
doaj   +1 more source

Cyclization of Quinazoline Derivatives

NIPPON KAGAKU KAISHI, 1973
7-Chloro-1, 2-dihydro-5-phenylimidazo (1, 2-a) quinazoline (4 a) and 8-chloro-2, 3-dihydro-6phenyl-1 H-pyrimido (1, 2-a) quinazoline (4 b) were synthesized by several steps from 2-amino5-chlorobenzophenone (1).6-Chloro-2 (B-hydroxyethylamino) 4-phenylquinazonline (3 a) was obtained from the., reactign The of2, 6-dichloro4-phenylquinazoline, which ...
Sundo Kwon, Fumio Ikeda, Kakuzo Isagawa
openaire   +2 more sources

Guanidine Derivatives of Quinazoline-2,4(1H,3H)-Dione as NHE-1 Inhibitors and Anti-Inflammatory Agents

Life, 2022
Quinazolines are a rich source of bioactive compounds. Previously, we showed NHE-1 inhibitory, anti-inflammatory, antiplatelet, intraocular pressure lowering, and antiglycating activity for a series of quinazoline-2,4(1H,3H)-diones and quinazoline-4(3H ...
Alexander Spasov, Alexander Ozerov, Vadim Kosolapov, Natalia Gurova, Aida Kucheryavenko, Ludmila Naumenko, Denis Babkov, Viktor Sirotenko, Alena Taran, Alexander Borisov, Elena Sokolova, Vladlen Klochkov, Darya Merezhkina, Mikhail Miroshnikov, Nadezhda Ovsyankina, Alexey Smirnov, Yulia Velikorodnaya   +16 more
doaj   +1 more source

A rapid and convenient method for synthesis of anilinoquinazoline: an improved synthesis of erlotinib derivatives [PDF]

Trends in Pharmaceutical Sciences, 2015
4-Anilinoquinazolines have been widely studied as anticancer agents. Despite the widespread use of this class of compounds, the reported syntheses of 4-anilinoquinazolines require multistep and lowyielding reaction pathways.
Zahra Haghighijoo, Zahra Rezaei, SamanehTaheri, Meisam Jani, Soghra Khabnadideh   +4 more
doaj   +4 more sources

REVIEW ON THE SIGNIFICANCE OF QUINAZOLINE DERIVATIVES AS BROAD SPECTRUM ANTI-CANCER AGENTS. [PDF]

Al-Azhar Journal of Pharmaceutical Sciences, 2021
Cancer is one of the major causes of human mortality worldwide. A number of approved antineoplastic medications and treatment regimens are already working in the field, and several new compounds are in different phases of clinical trials.
Mohamed El-Zahabi
doaj   +1 more source

Facile Preparation of 4-Substituted Quinazoline Derivatives [PDF]

Journal of Visualized Experiments, 2016
Reported in this paper is a very simple method for direct preparation of 4-substituted quinazoline derivatives from a reaction between substituted 2-aminobenzophenones and thiourea in the presence of dimethyl sulfoxide (DMSO). This is a unique complementary reaction system in which thiourea undergoes thermal decomposition to form carbodiimide and ...
Daniel Z, Wang, Lesong, Yan, Lingmei, Ma
openaire   +2 more sources

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

Dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives as potent and selective inhibitors targeting hepatitis B virus

Bangladesh Journal of Pharmacology, 2015
The construction of dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives (4a–4m), by  the condensation isatoic anhydride, appropriate amines and 2-formylbenzoic acid by using silica sulfuric acid as catalyst was reported.
Jun-Fei Zhang, Bo Liu, Cong-Xin Chen
doaj   +1 more source