Results 21 to 30 of about 387 (133)
The spectrogram data of quinazoline derivatives containing a dithioacetal moiety
Data in Brief, 2018 The nuclear magnetic resonance, and high-resolution mass spectrometry of quinazoline derivatives containing a dithioacetal moiety, which was hosted in the research article entitled “Syntheses, antiviral activities and induced resistance mechanisms of ...
Dandan Xie +9 more
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Antibiotics, 2023 Drug resistance is rising to alarming levels, constituting one of the major threats to global health. The overexpression of efflux pumps and the formation of biofilms constitute two of the most common resistance mechanisms, favoring the virulence of ...
Mariana C. Almeida +8 more
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Rational design and synthesis of quinazoline derivatives
İstanbul Journal of Pharmacy, 2021 Background and Aims: Alzheimer's disease is a neurodegenerative disorder in which the death of brain cells causes memory loss and cognitive decline. It is one of the leading causes of mortality worldwide. Several different hallmarks of the disease have been reported such as low levels of acetylcholine, deposits of β-amyloid around neurons ...
ALKHARAZ, Fatimah +3 more
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Research in Pharmaceutical Sciences, 2018 Quinazoline is one of the most widespread scaffolds amongst natural and synthetic bioactive compounds. Recently the quinazoline derivatives and in particular the 4-anilinoquinazolines have attracted much attention for their anticancer properties due to ...
Zahra Haghighijoo +5 more
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A simple copper-catalyzed two-step one-pot synthesis of indolo[1,2-a]quinazoline
Beilstein Journal of Organic Chemistry, 2014 A convenient CuI/L-proline-catalyzed, two-step one-pot method has been developed for the preparation of indolo[1,2-a]quinazoline derivatives using a sequential Ullmann-type C–C and C–N coupling.
Chunpu Li +3 more
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Quinazoline pharmacophore in therapeutic medicine
Bangladesh Journal of Pharmacology, 2016 This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic ...
Olayinka Oyewale Ajani +3 more
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Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms
BiomoleculesQuinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs.
Zhijiang Deng +7 more
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Prediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression method. [PDF]
PLoS ONE, 2011 The epidermal growth factor receptor (EGFR) protein tyrosine kinase (PTK) is an important protein target for anti-tumor drug discovery. To identify potential EGFR inhibitors, we conducted a quantitative structure-activity relationship (QSAR) study on the
Hongying Du +3 more
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Results in ChemistryIn this study, the synthesis of novel hybrid molecules derived from quinazoline and 1,2,3-triazoles was reported via copper-catalyzed click reaction. The reaction of quinazoline-4-one-2-thione and quinazoline-2,4-dione with 3-bromoprop-1-yne produced ...
Mahnaz Hashemipour +3 more
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Molecules, 2023 A practical method was developed for the convenient synthesis of isoxazole-fused tricyclic quinazoline alkaloids. This procedure accesses diverse isoxazole-fused tricyclic quinazoline alkaloids and their derivatives via intramolecular cycloaddition of ...
Zhuo Wang +9 more
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