Results 21 to 30 of about 623,955 (160)
Some novel hybrid quinazoline-based heterocycles as potent cytotoxic agents
Research in Pharmaceutical Sciences, 2022 Background and purpose: In this study, some new cytotoxic hybrid structures were synthesized by combining pyrazolinone and imidazolinone rings with quinazoline pharmacophores. Experimental approach: The benzoxazinone, pyrazolo-quinazoline fused ring, and
Mahla Malekzadeh +5 more
doaj +1 more source
Quinazoline analogues as cytotoxic agents; QSAR, docking, and in silico studies
Research in Pharmaceutical Sciences, 2021 Background and purpose: Synthesis and investigation of pharmacological activity of novel compounds are time and money-consuming. However, computational techniques, docking, and in silico studies have facilitated drug discovery research to design ...
Leila Emami +4 more
doaj +1 more source
A rapid and convenient method for synthesis of anilinoquinazoline: an improved synthesis of erlotinib derivatives [PDF]
Trends in Pharmaceutical Sciences, 2015 4-Anilinoquinazolines have been widely studied as anticancer agents. Despite the widespread use of this class of compounds, the reported syntheses of 4-anilinoquinazolines require multistep and lowyielding reaction pathways.
Zahra Haghighijoo +4 more
doaj +4 more sources
REVIEW ON THE SIGNIFICANCE OF QUINAZOLINE DERIVATIVES AS BROAD SPECTRUM ANTI-CANCER AGENTS. [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2021 Cancer is one of the major causes of human mortality worldwide. A number of approved antineoplastic medications and treatment regimens are already working in the field, and several new compounds are in different phases of clinical trials.
Mohamed El-Zahabi
doaj +1 more source
Susceptibility of different organisms to quinazoline derivatives.
, 2020 Susceptibility of different organisms to quinazoline derivatives.
Natalia Monakhova (8351475) +11 more
core +1 more source
Nanocatalyzed Synthetic Approach for the Quinazolinone and Quinazoline Derivatives: A Review (2015 – Present) [PDF]
, 2023 Due to their diverse chemical reactivities and essential range of biological action, quinazolines and their derivatives rank among the most significant heterocyclic compounds.
Lav Kush Kumar Vishwakarma +3 more
core +1 more source
Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA
Angewandte Chemie, EarlyView.The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid‐phase synthesis. Due to its isomorphic and isofunctional characteristics, tzG forms Watson–Crick base pairs and can be used as fluorescent probe to monitor (deoxy)ribozyme activity.
Julia Dietzsch +2 more
wiley +2 more sources
Current Progress in Quinazoline Derivatives as Acetylcholinesterase and Monoamine Oxidase Inhibitors
, 2021 Among the N-containing heterocyclic compounds, quinazoline-4-(3H)-one derivatives have been the center of attraction of medicinal and synthetic chemists due to their excellent versatility in biological activities that are witnessed by many approved drugs
Rehuman N. A. +6 more
core +1 more source
Research in Pharmaceutical Sciences, 2018 Quinazoline is one of the most widespread scaffolds amongst natural and synthetic bioactive compounds. Recently the quinazoline derivatives and in particular the 4-anilinoquinazolines have attracted much attention for their anticancer properties due to ...
Zahra Haghighijoo +5 more
doaj +1 more source
Antibiotics, 2023 Drug resistance is rising to alarming levels, constituting one of the major threats to global health. The overexpression of efflux pumps and the formation of biofilms constitute two of the most common resistance mechanisms, favoring the virulence of ...
Mariana C. Almeida +8 more
doaj +1 more source