Results 31 to 40 of about 24,939 (257)

Synthesis, Antibacterial, and Antioxidant Evaluation of Novel Series of Condensed Thiazoloquinazoline with Pyrido, Pyrano, and Benzol Moieties as Five- and Six-Membered Heterocycle Derivatives

Molecules, 2021
A novel synthesis of thiazolo[2,3-b]quinazolines 4(a–e), pyrido[2′,3′:4,5]thiazolo[2,3-b]quinazolines {5(a–e), 6(a–e), and 7(a–e)}, pyrano[2′,3′:4,5]thiazolo[2,3-b]quinazolines 8(a–e), and benzo[4,5]thiazolo[2,3-b]quinazoloine9(a–e) derivatives starting ...
Ebraheem Abdu Musad Saleh, Abdullah Mohammed AL Dawsari, Kakul Husain, Ismail Hassan Kutty, K.M.Lokanatha Rai   +4 more
doaj   +1 more source

A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro" [PDF]

, 2016
The progression of prostate cancer (PC) to a metastatic hormone refractory disease is the major contributor to the overall cancer mortality in men, mainly because the conventional therapies are generally ineffective at this stage. Thus, other therapeutic
Bolchi, Cristiano, Castelnovo, Luca, Colciago, Alessandra, FERRI, NICOLA, Fumagalli, Laura, Mornati, Ornella, Negri Cesi, Paola, Pallavicini, Marco, Valoti, Ermanno   +8 more
core   +2 more sources

Near‐Infrared‐Light‐Driven Photochemistry and Photocatalysis: Mechanisms, Recent Applications, and Opportunities in Organic Synthesis and Biology

Angewandte Chemie, Volume 138, Issue 17, 20 April 2026.
This minireview highlights recent advances in catalyst development and mechanistic strategies that enable photochemical and photocatalytic reactivity under 700–1000 nm NIR light, emphasizing how long‐wavelength excitation expands opportunities in both synthetic chemistry and biology.
Santosh K. Pagire, Wesley J. Olivier, Debabrata Maiti, Alex C. Bissember   +3 more
wiley   +2 more sources

Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives

Results in Chemistry
The rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures.
Vishwanath Halappanavar, Sangappa Teli, Hanamant B. Sannakki, Dharyappa Teli   +3 more
doaj   +1 more source

Synthesis and Spectral Characterization of 4,7-Dichloro-6-nitroquinazoline

Molbank, 2020
Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor (TKI) in the form of a dimaleate salt which is indicated for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC).
Thi Ngoc Nguyen, Thi Huong Tran, Nguyet Suong Huyen Dao, Van Giang Nguyen, Dinh Luyen Nguyen, Nguyen Trieu Trinh, Van Hai Nguyen   +6 more
doaj   +1 more source

Experimental, Spectroscopic, and Computational Insights into the Reactivity of “Methanal” with 2-Naphthylamines

Molecules, 2023
The reactions of 2-naphthylamine and methyl 6-amino-2-naphthoate with formalin and paraformaldehyde were studied experimentally, spectrally, and by quantum chemical calculations.
Martin Havlík, Tereza Navrátilová, Michaela Drozdová, Ameneh Tatar, Priscila A. Lanza, Diego Dusso, Elizabeth Laura Moyano, Carlos A. Chesta, Domingo Mariano A. Vera, Bohumil Dolenský   +9 more
doaj   +1 more source

Structure–Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase [PDF]

, 2013
To discover more potent p97 inhibitors, we carried out a structure–activity relationship study of the quinazoline scaffold previously identified from our HTS campaigns.
Chou, Tsui-Fen, Deshaies, Raymond J., Frankowski, Kevin J., Li, Kelin, Schoenen, Frank J.   +4 more
core   +2 more sources

Heterocyclic compounds with diverse biological activities: A review of quinazoline and quinazolinone derivatives

Results in Chemistry
Quinazoline and its derivative quinazolinone represent a vital class of nitrogen-containing heterocyclic compounds known for their diverse and potent biological activities.
Aditi Kalakwade, Rohini S. Kavalapure, Shankar Gharge, Shankar G. Alegaon, Shriram D. Ranade, Ling Shing Wong, Ramith Ramu   +6 more
doaj   +1 more source

Novel 2-phenyl-3-{4’-[N-(4”-aminophenyl)carbamoyl]-phenyl}-quinazoline-4(3H)one-6-sulphonic acidbased mono azo reactive dyes [PDF]

, 2011
A series of new heterocyclic mono azo reactive dyes 7a–m were prepared by diazotization of 2-phenyl-3-{4’-[N-(4”-aminophenyl)carbamoyl]-phenyl}-quinazoline-4(3H)-one-6-sulphonic acid (3) and coupling with various cyanurated coupling components 6a–m and ...
DIVYESH R. PATEL, KESHAV C. PATEL
core   +1 more source

Photocatalytic Cross‐Coupling of Phenols and Heteroaryl Halides With Machine Learning‐Guided Reaction Prediction

Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.
Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson, Alice Wu, Kalyana B. Duggal, Madeline E. Rotella, Marisa C. Kozlowski   +4 more
wiley   +2 more sources