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Düşük Karbon Çeliğinin Asidik Ortamdaki Korozyonuna Karşı İnhibitör Özelliği Gösteren 4-Okso-Kinazolin Türevi Katyonik Yüzey Aktif Maddelerin Sentezi

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
Birçok ülkede olduğu gibi bizimülkemizde de metal korozyonunu önlemeye yönelik kullanılan yöntemlerden biriuygun inhibitör kullanımıdır. Bu amaç doğrultusunda bu çalışmada,4-okso-kinazolin türevi olan uzun karbon zinciri içeren 3 adet katyonikpiridinyum ...
Serkan Öztürk
doaj   +1 more source

New symmetrical quinazoline derivatives selectively induce apoptosis in human cancer cells [PDF]

, 2006
In the search of new symmetrical derivatives with anticancer activity, we have looked for novel compounds able to induce a selective proapoptotic mechanism in cancer cells.
Bandres, E. (Eva), Cordeu, L. (Lucía), Cubedo, E. (Elena), Font, M. (María), Garcia-Foncillas, J. (Jesús), Malumbres, R. (Raquel), Palop-Cubillo, J.A. (Juan Antonio), Rebollo, A. (Amaia), Sanmartin-Grijalba, C. (Carmen)   +8 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Absolute Configurations and Chitinase Inhibitions of Quinazoline-Containing Diketopiperazines from the Marine-Derived Fungus Penicillium polonicum

Marine Drugs, 2020
Three new quinazoline-containing diketopiperazines, polonimides A–C (1–3), along with four analogues (4–7), were obtained from the marine-derived fungus Penicillium polonicum.
Xing-Chen Guo, Ya-Hui Zhang, Wen-Bin Gao, Li Pan, Hua-Jie Zhu, Fei Cao   +5 more
doaj   +1 more source

Study on the interaction of two quinazoline derivatives as novel PI3K/mTOR dual inhibitors and anticancer agents to human serum albumin utilizing spectroscopy and docking [PDF]

, 2023
Jiangang Chen, Xiaoli Bian, San‐Qi Zhang, Guangde Yang   +3 more
openalex   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Theoretical study on the protonation of AZA-aromatics [PDF]

, 1975
The protonation of azanaphthalenes and azabenzenes has been studied theoretically using CNDO/2 wavefunctions and perturbation theory in order to examine the correlation between pKa values and quantum-mechanical ...
Meer, Douwe van der, Weijer, Peter van de   +1 more
core   +2 more sources

Efficacy and safety of fruquintinib combined with albumin‐bound paclitaxel as second‐line therapy for advanced gastric cancer following failure of PD‐1 inhibitor‐containing treatment (TACTIC GC‐01): A phase II single‐arm study

International Journal of Cancer, Volume 158, Issue 9, Page 2219-2228, 1 May 2026.
What's new? Anti‐angiogenic drugs have shown promising efficacy as a second‐line treatment for advanced gastric cancer. However, it remains unclear how alterations in the tumor microenvironment following first‐line immunotherapy may impact tumor angiogenesis and influence subsequent therapeutic outcomes. This single‐arm study prospectively explored the
Xiaoting Ma, Kai Ou, Xiu Liu, Biyang Cao, Wenwei Yang, Jingyu Lu, Letian Zhang, Qi Wang, Lizhen Gao, Zhichao Jiang, Yongkun Sun, Lin Yang   +11 more
wiley   +1 more source

Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms

Biomolecules
Quinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs.
Zhijiang Deng, Jieming Li, Pengbo Zhu, Jie Wang, Yuanfang Kong, Yulong Hu, Juntao Cai, Chunhong Dong   +7 more
doaj   +1 more source

Recent Advances in Structural Optimization of Quinazoline-Based Protein Kinase Inhibitors for Cancer Therapy (2021–Present)

Molecules
Cancer is a complicated, multifaceted disease that can impact any organ in the body. Various chemotherapeutic agents have a low selectivity and are very toxic when used alone or in combination with others.
Heba T. Abdel-Mohsen, Manal M. Anwar, Nesreen S. Ahmed, Somaia S. Abd El-Karim, Sameh H. Abdelwahed   +4 more
doaj   +1 more source