Results 51 to 60 of about 13,731 (218)
Current Progress in Quinazoline Derivatives as Acetylcholinesterase and Monoamine Oxidase Inhibitors
, 2021 Among the N-containing heterocyclic compounds, quinazoline-4-(3H)-one derivatives have been the center of attraction of medicinal and synthetic chemists due to their excellent versatility in biological activities that are witnessed by many approved drugs
Rehuman N. A. +6 more
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Oxaziridines: Versatile Reagents in Modern Organic Synthesis
The Chemical Record, EarlyView.Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra +2 more
wiley +1 more source
Quinazoline derivatives as anticancer drugs: a patent review (2011-present)
, 2015 International audienceIntroduction: Quinazoline is one of the most studied moieties in medicinal chemistry due to the wide range of biological properties such as the anticancer, antibacterial, anti-inflammatory, antimalarial and antihypertensive ...
Ravez, Severine +3 more
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Susceptibility of different organisms to quinazoline derivatives.
, 2020 Susceptibility of different organisms to quinazoline derivatives.
Natalia Monakhova (8351475) +11 more
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Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Fruquintinib: Mechanism of Action, Clinical, and Translational Science
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Fruquintinib is a highly selective, oral inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3) that was approved, including in China, the United States, and the European Union, for the treatment of previously treated metastatic colorectal cancer (mCRC).
Xiaofei Zhou +7 more
wiley +1 more source
MoleculesCancer is a complicated, multifaceted disease that can impact any organ in the body. Various chemotherapeutic agents have a low selectivity and are very toxic when used alone or in combination with others.
Heba T. Abdel-Mohsen +4 more
doaj +1 more source
Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018 Birçok ülkede olduğu gibi bizimülkemizde de metal korozyonunu önlemeye yönelik kullanılan yöntemlerden biriuygun inhibitör kullanımıdır. Bu amaç doğrultusunda bu çalışmada,4-okso-kinazolin türevi olan uzun karbon zinciri içeren 3 adet katyonikpiridinyum ...
Serkan Öztürk
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Frontiers in Chemistry, 2020 CDK5/p25 kinase plays a major role in neuronal functions, and is hyperactivated in several human cancers including glioblastoma and neurodegenerative pathologies such as Alzheimer's and Parkinson's.
Marion Peyressatre +7 more
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ChemMedChem, Volume 21, Issue 18, 28 September 2026.The acid‐sensing ion channel 3 (ASIC3), physiologically located in the peripheral nervous system, was found in stem cells of CNS‐located glioblastoma multiforme (GBM CSCs); its chronic activation in the CNS kills dysfunctional GBM CSCs with no effect on ASIC3‐lacking CNS tissues.
Leonardo Maiorana +8 more
wiley +1 more source