Results 71 to 80 of about 9,016 (186)

Molecular Dynamics–Based validation of a quinazoline-based KRAS inhibitor (C9) identified through QSAR-guided discovery

Frontiers in Bioinformatics
BackgroundKRAS remains one of the most challenging oncogenic targets in lung cancer because of its shallow binding surfaces, conformational flexibility, and limited availability of druggable pockets.
Stephen Adebayo Osasan, Stephen Adebayo Osasan, Oche Ambrose George, Olusola Daramola, Oluwafemi Ayodele Adefolalu, Alzahrani A. Hind, Mohammad Alshehri Jawaher, Wisdom Onuche Ibrahim, Olanrewaju I. Ajetunmobi   +8 more
doaj   +1 more source

Amino-quinazolines [PDF]

Nature, 1945
A. KILLEN MACBETH, HAROLD J. RODDA
openaire   +1 more source

Discovery of A Novel Series of Quinazoline–Thiazole Hybrids as Potential Antiproliferative and Anti-Angiogenic Agents

Biomolecules
Considering the pivotal role of angiogenesis in solid tumor progression, we developed a novel series of quinazoline–thiazole hybrids (SA01–SA07) as antiproliferative and anti-angiogenic agents.
Alexandru Șandor, Ionel Fizeșan, Ioana Ionuț, Gabriel Marc, Cristina Moldovan, Ilioara Oniga, Adrian Pîrnău, Laurian Vlase, Andreea-Elena Petru, Ioana Macasoi, Ovidiu Oniga   +10 more
doaj   +1 more source

Efficient solid-phase synthesis of 1,2,3-benzotriazin-4-ones with SynPhaseTM Lanterns

Journal of the Brazilian Chemical Society, 2003
We have developed a solid-phase synthesis of 1,2,3-benzotriazin-4-ones through cyclization of 2-aminobenzamides via diazotization. The development of an efficient synthesis is important from the viewpoint of drug discovery, considering the various ...
Makino Shingo, Nakanishi Eiji, Tsuji Takashi   +2 more
doaj  

Reprogramming RiPP scaffolds through skeletal editing unlocks chemical space. [PDF]

Chem Sci
Ogawa H, Yu L, Li S, Nagata Y, Chan TK, Matsuda Y, Liu J, Li YX, Nakamura H.   +8 more
europepmc   +1 more source

Molecular docking, synthesis, and cytotoxic evaluation of novel quinazoline-quinazolinone hybrid compounds. [PDF]

Res Pharm Sci
Azarmi M, Rahimi S, Hormozi M, Rezaeinasab R.   +3 more
europepmc   +1 more source

Design, synthesis, and antibacterial activity study of pyrroloquinazoline diamine derivatives. [PDF]

J Enzyme Inhib Med Chem
Cheng M, Tian Y, Shang J, He W, Zheng Y, Yan C, Chen X, Li J, Jiang Y, Fu Q, Deng X, Xiao X, Song M.   +12 more
europepmc   +1 more source

Development of High-Affinity CHD1 Chromodomain Inhibitors. [PDF]

J Med Chem
Greschik H, Friedrich F, Seifert L, Mousavizadeh F, Fiorentino F, Walz J, Zhang L, Li J, Fabbrizi E, Tomassi S, Panahi F, Papenkordt N, Wurnig SL, Osterroth J, Strasser AM, Ruprecht J, Moumbock AFA, Hügle M, Sum M, Peng L, Wang S, Baniahmad AA, Pulido-Cortés L, Timmers HTM, Flaig R, Metzger E, Breit B, Einsle O, Günther S, Rotili D, Mai A, Schüle R, Jung M.   +32 more
europepmc   +1 more source

One-Pot Gateway to Quinazoline-Thiohydantoin Fused Scaffolds and Discovery of Their Antileukemic Activity. [PDF]

JACS Au
Kersting L, Zippel C, Herrmann L, Elbadawi M, Seo EJ, Heckmann F, Saeed MEM, Gaube A, Tailor D, Dheeraj A, Malhotra SV, Muehlich S, Efferth T, Tsogoeva SB.   +13 more
europepmc   +1 more source

RETRACTION: Synthesis, Characterization, and Anticancer Activity of New Quinazoline Derivatives against MCF-7 Cells. [PDF]

ScientificWorldJournal
Journal TSW.
europepmc   +1 more source