Results 61 to 70 of about 13,731 (218)
Quinazolinones as Potential Anticancer Agents: Synthesis and Action Mechanisms
BiomoleculesQuinazolinones, essential quinazoline derivatives, exhibit diverse biological activities with applications in pharmaceuticals and insecticides. Some derivatives have already been developed as commercial drugs.
Zhijiang Deng +7 more
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Analgetic Activity of a Quinazoline
Experimental Biology and Medicine, 1967 SummaryFour test systems were used to demonstrate the analgetic activity of Su-13026, a quinazoline compound, in mice, rats and rabbits. Signs of central nervous system stimulation were noted. Respiration was not depressed in any of the species studied. Nalorphine did not antagonize, nor did amphetamine potentiate, the activity of this compound in mice.
H I, Chernov +4 more
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Recent Advances on Quinazoline
This book investigates and identifies novel therapeutic compounds for the treatment of a range of illnesses. Heterocyclic compounds are a significant class of substances with biological activity.
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Marine Drugs, 2020 Three new quinazoline-containing diketopiperazines, polonimides A–C (1–3), along with four analogues (4–7), were obtained from the marine-derived fungus Penicillium polonicum.
Xing-Chen Guo +5 more
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On the Reaction of Quinazoline with Acetophenone
Chemical and Pharmaceutical Bulletin, 1964 Carbanion reacted as nucleophilic reagent with quinazoline. Reaction of quinazoline with acetophenone in the presence of sodium hydroxide solution at room temperature afforded 2-(3, 4-dihydro-4-quinazolinyl)acetophenone. The mechanism for this reaction may be suggested as in Chart 1 in the text.
Hayashi, Eisaku, Higashino, Takeo
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Archiv der Pharmazie, Volume 359, Issue 9, September 2026.We screened acrylamide bioisosteres against KRasG12C and prioritized primary hits by their GSH reactivity, labeling efficiency and specificity. The most promising fragment was combined with a KRas‐binding scaffold. Covalent binding, inhibitory activity and selectivity were confirmed via MS, NMR, biochemical and cell viability assays.
Nikolett Péczka +11 more
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Synthesis of Quinazoline Derivatives
Efficient synthesis of heterocyclic has always been a very important task in drug discovery. Most of the drugs contain heterocycles to provide an interface between chemistry and biology.
Yadav, Anjali +5 more
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Quinazoline Marketed drugs [PDF]
, 2015 Quinazoline is the main six-membered heterocyclic ring system reported for their biological activities, compounds with multiple pharmacophores, which bring together knowledge of a target with understanding of the molecule types that might interact with ...
Palanirajan Vijayaraj Kumar, Theivendren Panneer Selvam,
core
Biphenyl tricyclic quinazoline compounds
, 2012 The invention is directed to certain novel compounds with biphenyl tricyclic quinazoline structure. Specifically, the invention is directed to compounds of formula (I) and salts thereof.
GUIOTTO, ADRIANO +4 more
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Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease
MoleculesQuinazoline, a privileged scaffold in medicinal chemistry, offers promising potential in the synthesis of anti-Alzheimer’s disease (AD) drugs. This heterocyclic compound, characterized by its fused benzene and pyrimidine rings, enables the design of ...
Qais Abualassal +3 more
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