Results 81 to 90 of about 13,731 (218)

Preparation of chiral quinazoline derivatives [PDF]

, 2015
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Lukáš Górecki Consultant: prof. RNDr. Milan Pour, Ph.D.
Górecki, Lukáš
core   +1 more source

High-Yield Synthesis of N⁴-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)quinazoline-4,6-diamine via N-(3-Chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)-6-nitroquinazolin-4-amine

Molbank
The target compound, N4-(3-chloro-4-fluorophenyl)-7-((4-methoxybenzyl)thio)quinazoline-4,6-diamine, was synthesized in two steps from N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine by a nucleophilic aromatic substitution, yielding N-(3 ...
Susila Thapa, Jeanne L. Bolliger
doaj   +1 more source

Discovery of Potent c-MET Inhibitors with New Scaffold Having Different Quinazoline, Pyridine and Tetrahydro-Pyridothienopyrimidine Headgroups

Molecules, 2016
Cellular mesenchymal-epithelial transition factor (c-MET) is closely linked to human malignancies, which makes it an important target for treatment of cancer.
Yingnan Jiang, Ke Zhang, Suyu Gao, Guihua Wang, Jian Huang, Jinhui Wang, Lixia Chen   +6 more
doaj   +1 more source

2-Azidobenzaldehyde-Enabled Construction of Quinazoline Derivatives: A Review. [PDF]

Int J Mol Sci
Quinazoline is a privileged heterocyclic scaffold commonly found in numerous pharmaceuticals and bioactive natural products, known for its diverse biological activities.
Qiu W, Zhan D, Ma X, Zhang X.
europepmc   +2 more sources

Synthesis and properties of electroactive quinazoline-based compounds. [PDF]

, 2020
Electroactive organic compounds are used in optoelectronic devices such as organic light emitting diodes, solar cells. Quinazoline fragment was chosen as an acceptor moiety for the synthesis of new electroactive compounds due to its conjugated structure ...
Vekterytė, Simona,
core   +1 more source

Rational Design and Synthesis of a Novel Series of Thiosemicarbazone-Containing Quinazoline Derivatives as Potential VEGFR2 Inhibitors

Pharmaceutics
Background/Objectives: Angiogenesis plays a crucial role in tumor development and is a driving force for the aggressiveness of several types of cancer. Our team developed a novel series of thiosemicarbazone-containing quinazoline derivatives, TSC1-TSC10,
Alexandru Șandor, Ovidiu Crișan, Gabriel Marc, Ionel Fizeșan, Ioana Ionuț, Cristina Moldovan, Anca Stana, Ilioara Oniga, Adrian Pîrnău, Laurian Vlase, Andreea-Elena Petru, Ionuț-Valentin Creștin, Alex-Robert Jîjie, Brîndușa Tiperciuc, Ovidiu Oniga   +14 more
doaj   +1 more source

Synthesis of Heterocyclic Skeletons by the Reaction of N1-(2-Cyanophenyl)-benzimidoyl Chloride with Thioamides

Molecules, 2002
The reaction of N-(2-cyanophenyl)benzimidoyl chloride with reagents containing a thioamide moiety, i.e. thioacetamide, benzylthiourea, symmetrical dialkyl- and diarylthioureas gave different cyclic products: 3,1-benzothiazine, 1,3,5-benzotriazocine and ...
Pavel Pazdera, Walid M. Fathalla
doaj   +1 more source

Nucleosides Xi. Synthesis and Antiviral Evaluation of 5′-Alkylthio-5′- Deoxy Quinazolinone Nucleoside Derivatives as S-Adenosyl-L-Homocysteine Analogs

, 2009
4-Amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) was prepared by a direct glycosylation of 4-aminoquinazolin-2- one (7) using the Vorbruggen 's silylation method and provided exclusively the β-anomer.
簡敦誠;陳建樹;陳基旺, CHIEN, TUN-CHENG;CHEN, CHIEN-SHU;CHERN, JI-WANG   +1 more
core  

N2N N4-disubstituted quinazoline-2,4-diamines and uses thereof [PDF]

, 2019
Described herein are quinazoline-based compounds and formulations thereof. In some embodiments, the compounds and/or formulations thereof can be effective to inhibit and/or kill A. baumannii.
Flanigan, David Lawrence, Fleeman, Renee, Van Horn, Kurt S., Barber, Megan, Manetsch, Roman, Shaw, Lindsey N., Burda, Whittney   +6 more
core  

Regioselective Suzuki-Miyaura Reaction: Application to the Microwave-promoted Synthesis of 4,7-Diarylquinazolines

Molecules, 2010
New diarylquinazolines displaying pharmaceutical potential were synthesized in high yields from 4,7-dichloro-2-(2-methylprop-1-enyl)-6-nitroquinazoline by using microwave-promoted regioselective Suzuki-Miyaura cross-coupling reactions.
Patrice Vanelle, Armand Gellis, Pierre Verhaeghe, Youssef Kabri   +3 more
doaj   +1 more source