Results 41 to 50 of about 13,731 (218)
Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser +16 more
wiley +2 more sources
Synthesis of Lapachol and 4-Hydroxyquinazoline Derivatives as Candidates for Antimalarial Activity
Orbital: The Electronic Journal of Chemistry, 2020 Malaria is a disease that still plagues many tropical countries, affecting around 228 million people and with approximately 430 thousand deaths worldwide.
Felipe Revoredo Benatti +3 more
doaj +1 more source
EcoEnergy, EarlyView.A triflate‐functionalized Ni–Ce/MOF–OTf superacid enables low‐temperature (∼140°C) in situ upgrading of ultra‐deep heavy oil. It reduces viscosity by 92.11% in 12 h, maintains activity over cycles, and delivers 90.25% recovery with a lower carbon footprint by selective bond cleavage. ABSTRACT Ultra‐deep heavy oil is an important unconventional resource,
Li Wang +5 more
wiley +1 more source
Quinazoline derivatives: synthesis and bioactivities
, 2013 Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations ...
Wang, Dan, Feng Gao, Gao, Feng, Dan Wang
core +1 more source
Synthesis and Spectral Characterization of 4,7-Dichloro-6-nitroquinazoline
Molbank, 2020 Afatinib is a 4-anilinoquinazoline tyrosine kinase inhibitor (TKI) in the form of a dimaleate salt which is indicated for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC).
Thi Ngoc Nguyen +6 more
doaj +1 more source
Molecules, 2021 A novel synthesis of thiazolo[2,3-b]quinazolines 4(a–e), pyrido[2′,3′:4,5]thiazolo[2,3-b]quinazolines {5(a–e), 6(a–e), and 7(a–e)}, pyrano[2′,3′:4,5]thiazolo[2,3-b]quinazolines 8(a–e), and benzo[4,5]thiazolo[2,3-b]quinazoloine9(a–e) derivatives starting ...
Ebraheem Abdu Musad Saleh +4 more
doaj +1 more source
The Expanding Role of Diazirines in Synthetic Methodology
European Journal of Organic Chemistry, EarlyView.Beyond their established role in photoaffinity labeling, diazirines have emerged as versatile reagents in synthetic chemistry. This review highlights their dual reactivity as carbene and nitrogen‐transfer precursors, showcasing mechanistic insights and diverse applications in cyclopropanations, cycloadditions, skeletal editing, amination, heterocycle ...
Viktor Savic +3 more
wiley +1 more source
Phytotherapy Research, EarlyView.ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit +5 more
wiley +1 more source
Molecules, 2023 The reactions of 2-naphthylamine and methyl 6-amino-2-naphthoate with formalin and paraformaldehyde were studied experimentally, spectrally, and by quantum chemical calculations.
Martin Havlík +9 more
doaj +1 more source
Transformative Chemistry, EarlyView.This perspective highlights radical‐mediated 1,2‐boryl migration as a thermodynamically driven radical translocation strategy that enables the construction of diverse functionalized organoboronates, the transposition editing of organic molecules, and the synthesis of C3 alternating copolymers.
Chaoran Xu, Xiangcheng Pan
wiley +1 more source