Results 21 to 30 of about 24,939 (257)

N-(2-Methoxyphenyl)-2-nitrobenzamide [PDF]

, 2008
Geometric parameters of the title compound, C14H12N2O4, are in the usual ranges. The dihedral angle between the two aromatic rings is 28.9 (1)°. The nitro group is twisted by 40.2 (1)° out of the plane of the aromatic ring to which it is attached.
Saeed, Aamer, Hussain, Shahid, Bolte, Michael   +2 more
core   +1 more source

8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline

Chimica Techno Acta, 2020
The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained.
Yuri A. Azev, Olga S. Koptyaeva, Oleg S. Eltsov, Anton N. Tsmokalyuk, Tatyana A. Pospelova   +4 more
doaj   +1 more source

Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases

Scientia Pharmaceutica, 2023
Cancer is a large group of diseases that can affect any organ or body tissue due to the abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic agents are highly toxic with a low level of selectivity.
Mohamed F. Zayed
doaj   +1 more source

Synthesis, Characterization and Biological Activity Studies on 6-p-Dimethylaminophenyl-5,6-dihydrobenzoimidazo[1,2-c]quinazoline: Crystal Structure of the Title Compound and Comparative Study with Related Derivatives [PDF]

, 2012
Reaction of o-aminophenylbenzimidazole with p-dimethylaminobenzaldehyde yielded 6-p-dimethylaminophenyl-5,6-dihydrobenzoimidazo[1,2-c]quinazoline, which was characterized by elemental analysis, IR, UV-Vis, H-1 NMR, C-13 NMR, mass spectral studies and X ...
Bhattacharjee, R., Bubbly, S.G., Gayathri, V., Gowda, N.M.N., Gudennavar, S.B., Natarajan, S.   +5 more
core   +1 more source

Synthesis and properties of quinazoline-based versatile exciplex-forming compounds

Beilstein Journal of Organic Chemistry, 2020
Three compounds, bearing a quinazoline unit as the acceptor core and carbazole, dimethyldihydroacridine, or phenothiazine donor moieties, were designed and synthesized in two steps including a facile copper-catalyzed cyclization and a nucleophilic ...
Rasa Keruckiene, Simona Vekteryte, Ervinas Urbonas, Matas Guzauskas, Eigirdas Skuodis, Dmytro Volyniuk, Juozas V. Grazulevicius   +6 more
doaj   +1 more source

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here.
Victor Sebastian-Perez, Alfonso García-Rubia, Sayed H. Seif el-Din, Abdel-Nasser A. Sabra, Naglaa M. El-Lakkany, Samia William, Tom L. Blundell, Louis Maes, Ana Martinez, Nuria E. Campillo, Sanaa S. Botros, Carmen Gil   +11 more
doaj   +1 more source

Silodosin inhibits noradrenaline-activated transcription factors Elk1 and SRF in human prostate smooth muscle. [PDF]

, 2012
The transcription factors Elk1 and serum response factor (SRF) are central regulators of cell cycle and phenotype in various cell types. Elk1 is activated by phosphorylation (serine-383), while activation of SRF requires its co-factor, myocardin ...
Andersson, Karl-Erik, Beckmann, Christer, Füllhase, Claudius, Gratzke, Christian, Hedlund, Petter, Hennenberg, Martin, Montorsi, Francesco, Rutz, Beata, Stief, Christian Georg, Strittmatter, Frank, Waidelich, Raphaela   +10 more
core   +2 more sources

Study of the Anti-klebsiella Activity of Quinazoline Compounds Containing a Piperazine Ring

Антибиотики и Химиотерапия
The aim of this study was to investigate the antimicrobial activity of piperazine ring-containing quinazoline compounds against Klebsiella pneumoniae.
A. A. Tsibizova, A. L. Yasenyavskaya, G. N. Genatullina, A. A. Ozerov, M. A. Samotrueva   +4 more
doaj   +1 more source

Synthesis, Characterization and Antifungal Activity of Novel Quinazolin-4-one Derivatives Containing 8-Hydroxyquinazoline Ligand and its Various Metal Complexes

E-Journal of Chemistry, 2009
Novel ligands containing quinazoline-4-one-8-hydroxyquinoline (QQ) merged moieties were prepared and characterized. For this anthranilic acid and 5-bromoanthranilic acid were converted respectively into 2-chloromethyl–3-(4-methyl phenyl)-3(H)-quinazoline-
R. T. Vashi, S. B. Patel
doaj   +1 more source

Synthesis of Lapachol and 4-Hydroxyquinazoline Derivatives as Candidates for Antimalarial Activity

Orbital: The Electronic Journal of Chemistry, 2020
Malaria is a disease that still plagues many tropical countries, affecting around 228 million people and with approximately 430 thousand deaths worldwide.
Felipe Revoredo Benatti, Keoma Keyson Lima Cavalcante, Alexandre Orsato, Carla Cristina Perez   +3 more
doaj   +1 more source