Results 21 to 30 of about 13,731 (218)
Crystal structure of 4-methylsulfanyl-2-phenylquinazoline
Acta Crystallographica Section E, 2014 In the title compound, C15H12N2S, the methylthioquinazoline group is planar with the methyl C displaced by only 0.116 (3) Å from the plane of the quinazoline moiety. The dihedral angle between the phenyl ring and the quinazoline ring system is 13.95 (5)°.
Mohammed B. Alshammari +4 more
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Structure-Activity Relationship and Docking Study of Non-Quinazoline EGFR/VEGFR Dual Inhibitors. A Review [PDF]
Iranian Journal of Chemistry & Chemical EngineeringThe dual inhibitors of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2) have been developed as a promising strategy for cancer therapy.
Fatemeh Yousefbeyk, Saeed Ghasemi
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Quinazolinone-based hybrids with diverse biological activities: A mini-review
Journal of Research in Medical Sciences, 2022 Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial.
Rezvan Rezaeinasab +2 more
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Isothiazologuanosine (tzG) as Environmentally Sensitive Fluorescent Reporter in RNA
Angewandte Chemie, EarlyView.The emissive isothiazologuanosine analog tzG is synthesized for the first time as RNA phosphoramidite building block for solid‐phase synthesis. Due to its isomorphic and isofunctional characteristics, tzG forms Watson–Crick base pairs and can be used as fluorescent probe to monitor (deoxy)ribozyme activity.
Julia Dietzsch +2 more
wiley +2 more sources
Proceedings, 2020 The crystal structures of 4-(3,4-dimethoxyphenylethylamino)-methylidene-2,3,4,10-tetrahydro-1H-pyrido[2,1-b]-quinazolin-10-one (1) and 4-(3,4-methylene-dioxyphenylethylamino)-methylidene-2,3,4,10-tetrahydro-1H-pyrido[2,1-b]-quina-zolin-10-one ...
Akmaljon Tojiboev +7 more
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Quinazoline Based HDAC Dual Inhibitors as Potential Anti-Cancer Agents
Molecules, 2022 Cancer is the most devastating disease and second leading cause of death around the world. Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocrine therapy, immunotherapy ...
Jyothi Dhuguru, Ola A. Ghoneim
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Study of the Anti-klebsiella Activity of Quinazoline Compounds Containing a Piperazine Ring
Антибиотики и ХимиотерапияThe aim of this study was to investigate the antimicrobial activity of piperazine ring-containing quinazoline compounds against Klebsiella pneumoniae.
A. A. Tsibizova +4 more
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Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening
Journal of Saudi Chemical Society, 2011 A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles,
Ahmed M. Alafeefy +4 more
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Results in ChemistryIn this study, the synthesis of novel hybrid molecules derived from quinazoline and 1,2,3-triazoles was reported via copper-catalyzed click reaction. The reaction of quinazoline-4-one-2-thione and quinazoline-2,4-dione with 3-bromoprop-1-yne produced ...
Mahnaz Hashemipour +3 more
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Chimica Techno Acta, 2020 The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained.
Yuri A. Azev +4 more
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