Results 21 to 30 of about 9,016 (186)

8-Hydroxy-5-nitroquinoline as a C-nucleophilic reagent in the reaction of C, C-coupling with quinazoline

Chimica Techno Acta, 2020
The first example of the reaction of 5-nitro-8-hydroxyquinoline as a C-nucleophile with quinazoline is described. As a result of the reaction of C, C-coupling, a stable σ-adduct containing the drug nitroxalin on a heterocyclic carrier was obtained.
Yuri A. Azev, Olga S. Koptyaeva, Oleg S. Eltsov, Anton N. Tsmokalyuk, Tatyana A. Pospelova   +4 more
doaj   +1 more source

Medicinal Chemistry of Quinazolines as Anticancer Agents Targeting Tyrosine Kinases

Scientia Pharmaceutica, 2023
Cancer is a large group of diseases that can affect any organ or body tissue due to the abnormal cellular growth with the unknown reasons. Many of the existing chemotherapeutic agents are highly toxic with a low level of selectivity.
Mohamed F. Zayed
doaj   +1 more source

Synthesis of some new substituted iodoquinazoline derivatives and their antimicrobial screening

Journal of Saudi Chemical Society, 2011
A new series of 6-iodo-2-thienylquinazolin-4(3H)-one and its fused heterocyclic analogs were prepared and screened for their antimicrobial activity. Compounds 4, 8, 14 and 24 showed remarkable broad spectrum antimicrobial activity. The fused heterocycles,
Ahmed M. Alafeefy, Adel S. El-Azab, Menshawy A. Mohamed, Mohamed Afroz Bakhat, S. G. Abdel-Hamid   +4 more
doaj   +1 more source

Study of the Anti-klebsiella Activity of Quinazoline Compounds Containing a Piperazine Ring

Антибиотики и Химиотерапия
The aim of this study was to investigate the antimicrobial activity of piperazine ring-containing quinazoline compounds against Klebsiella pneumoniae.
A. A. Tsibizova, A. L. Yasenyavskaya, G. N. Genatullina, A. A. Ozerov, M. A. Samotrueva   +4 more
doaj   +1 more source

Synthesis and properties of quinazoline-based versatile exciplex-forming compounds

Beilstein Journal of Organic Chemistry, 2020
Three compounds, bearing a quinazoline unit as the acceptor core and carbazole, dimethyldihydroacridine, or phenothiazine donor moieties, were designed and synthesized in two steps including a facile copper-catalyzed cyclization and a nucleophilic ...
Rasa Keruckiene, Simona Vekteryte, Ervinas Urbonas, Matas Guzauskas, Eigirdas Skuodis, Dmytro Volyniuk, Juozas V. Grazulevicius   +6 more
doaj   +1 more source

Hybrid molecules derived from quinazoline and 1,2,3-triazoles: synthesis and antibacterial activity evaluation

Results in Chemistry
In this study, the synthesis of novel hybrid molecules derived from quinazoline and 1,2,3-triazoles was reported via copper-catalyzed click reaction. The reaction of quinazoline-4-one-2-thione and quinazoline-2,4-dione with 3-bromoprop-1-yne produced ...
Mahnaz Hashemipour, Ali Keivanloo, Mohammad Bakherad, Hossein Aghamollaei   +3 more
doaj   +1 more source

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising in vitro activity against Schistosoma mansoni. Follow-up studies of the antischistosomal potential of this candidate are presented here.
Victor Sebastian-Perez, Alfonso García-Rubia, Sayed H. Seif el-Din, Abdel-Nasser A. Sabra, Naglaa M. El-Lakkany, Samia William, Tom L. Blundell, Louis Maes, Ana Martinez, Nuria E. Campillo, Sanaa S. Botros, Carmen Gil   +11 more
doaj   +1 more source

Quinazoline scaffold as a target for combating microbial resistance: Synthesis and antimicrobial profiling of quinazoline derivatives

Results in Chemistry
The rise of drug-resistant microbial pathogens necessitates the development of innovative antimicrobial agents. Quinazoline derivatives exhibit promising pharmacological effects and diverse chemical structures.
Vishwanath Halappanavar, Sangappa Teli, Hanamant B. Sannakki, Dharyappa Teli   +3 more
doaj   +1 more source

Synthesis, Characterization and Antifungal Activity of Novel Quinazolin-4-one Derivatives Containing 8-Hydroxyquinazoline Ligand and its Various Metal Complexes

E-Journal of Chemistry, 2009
Novel ligands containing quinazoline-4-one-8-hydroxyquinoline (QQ) merged moieties were prepared and characterized. For this anthranilic acid and 5-bromoanthranilic acid were converted respectively into 2-chloromethyl–3-(4-methyl phenyl)-3(H)-quinazoline-
R. T. Vashi, S. B. Patel
doaj   +1 more source

Structure based design and anti-breast cancer evaluation of some novel 4-anilinoquinazoline derivatives as potential epidermal growth factor receptor inhibitors

Research in Pharmaceutical Sciences, 2018
Quinazoline is one of the most widespread scaffolds amongst natural and synthetic bioactive compounds. Recently the quinazoline derivatives and in particular the 4-anilinoquinazolines have attracted much attention for their anticancer properties due to ...
Zahra Haghighijoo, Zahra Rezaei, Mansooreh Jaberipoor, Samaneh Taheri, Meysam Jani, Soghra Khabnadideh   +5 more
doaj   +1 more source