Quinazolinone-based hybrids with diverse biological activities: A mini-review
Journal of Research in Medical Sciences, 2022 Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial.
Rezvan Rezaeinasab +2 more
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Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines [PDF]
, 2019 The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products.
Arachchige, Pandula T. Kirinde +1 more
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Design and Molecular Docking Studies of Quinazoline Derivatives as Antiproliferation
Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, 2018 Background: Nowadays, a lot of new active substances as anticancer agents have been developed. One of the protein targets of anticancer is selective cyclooxygenase-2 (COX-2). Selective COX-2 is the regulator of cell proliferation.
Anita Puspa Widiyana +4 more
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Polymyxins and quinazolines are LSD1/KDM1A inhibitors with unusual structural features [PDF]
, 2016 Because of its involvement in the progression of several malignant tumors, the histone lysine-specific demethylase 1 (LSD1) has become a prominent drug target in modern medicinal chemistry research.
Ciossani, Giuseppe +11 more
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Proceedings, 2020 The crystal structures of 4-(3,4-dimethoxyphenylethylamino)-methylidene-2,3,4,10-tetrahydro-1H-pyrido[2,1-b]-quinazolin-10-one (1) and 4-(3,4-methylene-dioxyphenylethylamino)-methylidene-2,3,4,10-tetrahydro-1H-pyrido[2,1-b]-quina-zolin-10-one ...
Akmaljon Tojiboev +7 more
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Quinazoline Based HDAC Dual Inhibitors as Potential Anti-Cancer Agents
Molecules, 2022 Cancer is the most devastating disease and second leading cause of death around the world. Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocrine therapy, immunotherapy ...
Jyothi Dhuguru, Ola A. Ghoneim
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Novel applications of the "t-amino effect" in heterocyclic chemistry. Synthesis of a pyrrolo[1,2-a]quinazoline and 5H-pyrrolo[1,2-a][3,1]benzothiazines [PDF]
, 1984 1-(1-Pyrrolidinyl)benzenes substituted with an imino- or an in situ generated thiocarbonyl group in the 2-position rearrange upon heating to quinazoline and benzothiazine derivatives ...
Hamzink, M.R.J. +3 more
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A Pilot retrospective analysis of alpha-blockers on recurrence in men with localised prostate cancer treated with radiotherapy [PDF]
, 2020 While alpha-blockers are commonly used to reduce lower urinary tract symptoms in prostate cancer patients receiving radiotherapy, their impact on response to radiotherapy remains unknown.
Anoopkumar-Dukie, Shailendra +6 more
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Crystal structure of 4-methylsulfanyl-2-phenylquinazoline
Acta Crystallographica Section E, 2014 In the title compound, C15H12N2S, the methylthioquinazoline group is planar with the methyl C displaced by only 0.116 (3) Å from the plane of the quinazoline moiety. The dihedral angle between the phenyl ring and the quinazoline ring system is 13.95 (5)°.
Mohammed B. Alshammari +4 more
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Diazanaphthalenes: A 13C NMR investigation on the site of protonation and pKa values [PDF]
, 1976 The pH dependence of the 13C chemical shifts (δ) of the diazanaphthalenes has been recorded. From this dependence the pKa values have been determined using the Henderson-Hasselbach equation.
Meer, Douwe van der +2 more
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