Results 11 to 20 of about 9,016 (186)
Design, Synthesis of Novel Quinazolinone Derivatives and Evaluation of EGFR Kinase Inhibition Activity via In Vitro and In Silico Studies. [PDF]
Chem Biol Drug DesSeventeen new quinazolinone derivatives were synthesized in pure form. Compound 4j showed the highest inhibitory activity against the A549 cell line and induced apoptosis via caspase‐3 activation in MCF‐7 cells. 4j inhibited EGFR enzyme twice as effectively as gefitinib.
Kaya AZ +3 more
europepmc +2 more sources
Quinazoline derivatives: synthesis and bioactivities [PDF]
Chemistry Central Journal, 2013 Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations of quinazoline derivatives. According to the main method the authors adopted in their research design,
Wang, Dan, Gao, Feng
openaire +5 more sources
Quinazolinone-based hybrids with diverse biological activities: A mini-review
Journal of Research in Medical Sciences, 2022 Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti-inflammatory, anti-hyperlipidemia, analgesic, antihypertensive, and antibacterial.
Rezvan Rezaeinasab +2 more
doaj +1 more source
Quinazoline pharmacophore in therapeutic medicine
Bangladesh Journal of Pharmacology, 2016 This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic ...
Olayinka Oyewale Ajani +3 more
doaj +1 more source
Analgetic Activity of a Quinazoline
Experimental Biology and Medicine, 1967 SummaryFour test systems were used to demonstrate the analgetic activity of Su-13026, a quinazoline compound, in mice, rats and rabbits. Signs of central nervous system stimulation were noted. Respiration was not depressed in any of the species studied. Nalorphine did not antagonize, nor did amphetamine potentiate, the activity of this compound in mice.
H I, Chernov +4 more
openaire +2 more sources
Proceedings, 2020 The crystal structures of 4-(3,4-dimethoxyphenylethylamino)-methylidene-2,3,4,10-tetrahydro-1H-pyrido[2,1-b]-quinazolin-10-one (1) and 4-(3,4-methylene-dioxyphenylethylamino)-methylidene-2,3,4,10-tetrahydro-1H-pyrido[2,1-b]-quina-zolin-10-one ...
Akmaljon Tojiboev +7 more
doaj +1 more source
Quinazoline Based HDAC Dual Inhibitors as Potential Anti-Cancer Agents
Molecules, 2022 Cancer is the most devastating disease and second leading cause of death around the world. Despite scientific advancements in the diagnosis and treatment of cancer which can include targeted therapy, chemotherapy, endocrine therapy, immunotherapy ...
Jyothi Dhuguru, Ola A. Ghoneim
doaj +1 more source
On the Reaction of Quinazoline with Acetophenone
Chemical and Pharmaceutical Bulletin, 1964 Carbanion reacted as nucleophilic reagent with quinazoline. Reaction of quinazoline with acetophenone in the presence of sodium hydroxide solution at room temperature afforded 2-(3, 4-dihydro-4-quinazolinyl)acetophenone. The mechanism for this reaction may be suggested as in Chart 1 in the text.
Hayashi, Eisaku, Higashino, Takeo
openaire +3 more sources
Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2
Angewandte Chemie, EarlyView.By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin +3 more
wiley +2 more sources
On the Reaction of Quinazoline with Ketones
Chemical and Pharmaceutical Bulletin, 1965 The structures of the reaction products, III, IV, and V, obtained in the interaction between quinazoline and acetone, 2-butanone and cyclohexanone in the presence of hydroxide anion at room temperature, were determined to be 1-(3, 4-dihydro-4-quinazolinyl)-4-hydroxy-4-methyl-2-pentanone (III), 1-(3, 4-dihydro-4-quinazolinyl)-4-hydroxy-3, 4-dimethyl-2 ...
Hayashi, Eisaku, Higashino, Takeo
openaire +3 more sources