Quinazoline pharmacophore in therapeutic medicine [PDF]
Bangladesh Journal of Pharmacology, 2016 This present study comprehensively expatiates the functionalized utilization of quinazoline scaffolds in drug development and furnishes latest updates in pharmacological appositeness of its derivatives in order to reveal novel pathways for therapeutic ...
Olayinka Oyewale Ajani +3 more
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New pathways for the synthesis of indolyl-containing quinazoline trifluoroacetohydrazides [PDF]
Chimica Techno Acta, 2020 The reactions of indole-3-carbaldehyde arylhydrazones with quinazoline in TFA proceed at the 7' position of the aryl part of the hydrazone molecule to form σ-adducts of quinazoline trifluoroacetohydrazides.
Yu. A. Azev +4 more
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Design, Synthesis, Molecular Dynamics, and In Vitro Evaluation of Isatin-Based Quinazoline Derivatives as Potential Antidiabetic Agents. [PDF]
Chem BiodiversA series of substituted indolo[2,1‐b]quinazoline‐6,12‐diones (SJ1‐SJ8) has been studied for their possible α‐amylase inhibition property as an antidiabetic lead compound. The most potent inhibitory activity among the tested derivatives was showed by SJ2 (IC50 = 18.49 ± 0.06 µM), similar to the reference drug acarbose (IC50 = 16.26 ± 0.02 µM).
Jaidka S +4 more
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, 2023 Matrix metalloproteinase-13 (MMP-13) plays a critical role in the progression of unstable atherosclerosis. A series of highly potent and selective MMP-13 inhibitors were synthesized around a quinazoline-2-carboxamide scaffold to facilitate radiolabeling ...
Faduma Abdirahman +17 more
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Synthesis of potent antileukemic quinazoline-thiohydantoin fused heterocycles enabled by metal-free domino reaction [PDF]
, 2023 Heterocyclic compounds play a central role in drug development research and are contained in most pharmaceuticals on the market. Quinazoline and thiohydantoin are heterocycles and hold very prominent positions due to their diverse pharmacological ...
Svetlana B., Tsogoeva +11 more
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Computational investigation on natural quinazoline alkaloids as potential inhibitors of the main protease (Mpro) of SARS_CoV_2 [PDF]
, 2021 Drug discovery is still behind in the race compared to vaccine discovery in fighting COVID-19. Recently, a few alkaloids from a traditional Indian medicinal plant, Vasaka (Justicia adhatoda), have been linked computationally to the main protease (Mpro ...
Deb Ranjan, Banerjee +4 more
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Synthesis Of Some Substituted 1,2,5-Oxadiazino [2-3,b] Quinazoline And Some 1,3-Oxazole Derivatives [PDF]
مجلة التربية والعلم, 2013 In this paper the synthesis of some 1,2,5- oxadiazino [2-3,b] quinazoline and some substituted 1,3- oxazole are reported, alanine and valine were reacted with benzoyle chloride in sodium hydroxide solution to give N- benzoyle alanine or valine (1,2 ...
Yassir S. Mohamad
doaj +1 more source
Quinazoline-Containing Indole Alkaloids from the Marine-Derived Fungus Aspergillus sp. HNMF114
, 2019 Seven new quinazoline-containing indole alkaloids (1–7) named aspertoryadins A–G, along with nine known ones (8–16), were isolated from the marine-derived fungus Aspergillus sp. HNMF114 from the bivalve mollusk Sanguinolaria chinensis.
Jiu-Hui Li (4404250) +12 more
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Setting of an import tolerance for fenazaquin in teas. [PDF]
EFSA JAbstract In accordance with Article 6 of Regulation (EC) No 396/2005, the applicant Gowan Crop Protection Limited submitted a request to the competent national authority in Germany to set an import tolerance for the active substance fenazaquin in teas imported from India.
European Food Safety Authority (EFSA) +10 more
europepmc +2 more sources
DESIGN AND SYNTHESIS OF NOVEL TERREMIDE AND SULFONAIDES DERIVATIVES FOR PHARMACOLOGICAL EVALUATION [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2022 Bacterial infections were first recorded back at 3000 B.C.E. Since then, there have been an enormous number of pandemics that hit the world. Countless doctors and researchers have been working on a definitive solution to exterminate all bacterial ...
Abdelrahman Hussien +3 more
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