Results 71 to 80 of about 8,749 (208)
Oxaziridines: Versatile Reagents in Modern Organic Synthesis
The Chemical Record, EarlyView.Being capable of transferring an O atom and N‐group/atom, oxaziridines are considered multitasking agents. These are employed for diverse organic transformations, such as epoxidation of olefins, α‐ and γ‐hydroxylation/amination of carbonyl compounds, oxidation of sulfides, [3+2]cycloaddition with unsaturated systems.
Ajeet Chandra +2 more
wiley +1 more source
2,4-Disubstituted quinazolines as potential ligands for CAR receptors [PDF]
, 2012 Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Inorganic and Organic Chemistry Candidate: Marcela Drechslerová Consultant: PharmDr. Marcel Špulák, PhD.
Drechslerová, Marcela
core
Accessing Polysubstituted Quinazolines via Nickel Catalyzed Acceptorless Dehydrogenative Coupling
, 2018 Two environmentally benign methods for the synthesis of quinazolines via acceptorless dehydrogenative coupling of 2-aminobenzylamine with benzyl alcohol (Path A) and 2-aminobenzylalcohol with benzonitrile (Path B), catalyzed by cheap, earth abundant and ...
Seuli Parua (4224352) +5 more
core +1 more source
An expedient synthesis of oxazepino and oxazocino quinazolines [PDF]
, 2015 A synthetic route to a new class of privileged tri- and tetra-cyclic quinazolines containing a medium-sized ring is reported. An expedient synthetic route involving nucleophilic aromatic substitution, and sequential Niementowski and BOP-mediated ring ...
Mills, VR +7 more
core +2 more sources
Synthesis of 3-[2-(1H-imidazol-2-yl)alkyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one derivatives
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2018 Promising biologically active substances are derivatives of imidazole and quinazoline, which are part of the structure of known antifungal drugs and substances with anti-TB and antimicrobial activity.
O. A. Zavada +2 more
doaj +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
, 2005 1940-1943Anthranilic acid on treatment with an aromatic acid chloride in pyridine gives 2-aryl-4-oxo-3H-benzoxazines 1 which reacts with p-aminobenzoic acid to afford 2-aryl-3-p-carboxylatophenyl-4-oxo-3H-quinazolines 2.
Mishra, S K +5 more
core +1 more source
, 2023 The efficient synthesis of fluoroalkylated pyrazolo[1,5-c]quinazolines by reactions of 3-diazoindolin-2-ones with methyl β-fluoroalkylpropionates has been achieved.
Liu-Yan Qiu +15 more
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Fruquintinib: Mechanism of Action, Clinical, and Translational Science
Clinical and Translational Science, Volume 19, Issue 10, October 2026.ABSTRACT Fruquintinib is a highly selective, oral inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3) that was approved, including in China, the United States, and the European Union, for the treatment of previously treated metastatic colorectal cancer (mCRC).
Xiaofei Zhou +7 more
wiley +1 more source
One-Pot Quinazolin-4-ylidenethiourea Synthesis via N-(2-Cyanophenyl)benzimidoyl isothiocyanate
Molecules, 2001 1,1-Disubstituted-3-(2-phenyl-3H-quinazolin-4-ylidene)thioureas (8) were synthesized in a one pot reaction of N-(2-cyanophenyl)benzimidoyl isothicyanate (3) with secondary amines. The products underwent transamination reactions.
Pavel Pazdera +3 more
doaj +1 more source