Results 81 to 90 of about 8,749 (208)
Direct Synthesis of Quinazolines through Copper-Catalyzed Reaction of Aniline-Derived Benzamidines
, 2016 A novel synthesis of 2-phenyl-4-[(triisopropylsilyl)methyl]quinazolines from monosubstituted arenes has been developed. Treatment of N-phenylbenzamidines with 5-nitro-1-[(triisopropylsilyl)ethynyl]-1,2-benziodoxol-3(1H)-one and K2CO3 in the presence of a
Hiroaki Ohno (1457971) +4 more
core +1 more source
Analgetic Activity of a Quinazoline
Experimental Biology and Medicine, 1967 SummaryFour test systems were used to demonstrate the analgetic activity of Su-13026, a quinazoline compound, in mice, rats and rabbits. Signs of central nervous system stimulation were noted. Respiration was not depressed in any of the species studied. Nalorphine did not antagonize, nor did amphetamine potentiate, the activity of this compound in mice.
H I, Chernov +4 more
openaire +2 more sources
Research in Pharmaceutical Sciences, 2016 The heterocyclic compounds have a great importance in medicinal chemistry. One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant ...
Elham Jafari +4 more
doaj
On the Reaction of Quinazoline with Acetophenone
Chemical and Pharmaceutical Bulletin, 1964 Carbanion reacted as nucleophilic reagent with quinazoline. Reaction of quinazoline with acetophenone in the presence of sodium hydroxide solution at room temperature afforded 2-(3, 4-dihydro-4-quinazolinyl)acetophenone. The mechanism for this reaction may be suggested as in Chart 1 in the text.
Hayashi, Eisaku, Higashino, Takeo
openaire +3 more sources
Archiv der Pharmazie, Volume 359, Issue 9, September 2026.We screened acrylamide bioisosteres against KRasG12C and prioritized primary hits by their GSH reactivity, labeling efficiency and specificity. The most promising fragment was combined with a KRas‐binding scaffold. Covalent binding, inhibitory activity and selectivity were confirmed via MS, NMR, biochemical and cell viability assays.
Nikolett Péczka +11 more
wiley +1 more source
Molecules, 2020 A series of 3-ethyl(methyl)-2-thioxo-2,3-dihydrobenzo[g]quinazolines (1–17) were synthesized, characterized, and evaluated in vitro for their antiangiogenesis VEGFR-2-targeting, antiproliferative, and antiapoptotic activities against breast MCF-7 and ...
Hatem A. Abuelizz +6 more
doaj +1 more source
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.A series of substituted indolo[2,1‐b]quinazoline‐6,12‐diones (SJ1‐SJ8) has been studied for their possible α‐amylase inhibition property as an antidiabetic lead compound. The most potent inhibitory activity among the tested derivatives was showed by SJ2 (IC50 = 18.49 ± 0.06 µM), similar to the reference drug acarbose (IC50 = 16.26 ± 0.02 µM).
Sahil Jaidka +4 more
wiley +1 more source
On the Reaction of Quinazoline with Ketones
Chemical and Pharmaceutical Bulletin, 1965 The structures of the reaction products, III, IV, and V, obtained in the interaction between quinazoline and acetone, 2-butanone and cyclohexanone in the presence of hydroxide anion at room temperature, were determined to be 1-(3, 4-dihydro-4-quinazolinyl)-4-hydroxy-4-methyl-2-pentanone (III), 1-(3, 4-dihydro-4-quinazolinyl)-4-hydroxy-3, 4-dimethyl-2 ...
Hayashi, Eisaku, Higashino, Takeo
openaire +3 more sources
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.This review majorly describes the systematic development of Akt inhibitors involving numerous heterocyclic scaffolds along with their structure activity relationships to explore anticancer therapeutic strategies. ABSTRACT The Akt pathway is dysregulated in cancer, leading to proliferation, decreased apoptosis, and metastasis, and hence is a major ...
Mayur S. Dhangar, Mahesh B. Palkar
wiley +1 more source
MoleculesA series of indolinone-based derivatives were designed and synthesized using the hybrid pharmacophoric design approach as cytotoxic kinase inhibitors.
Manal M. Kandeel +4 more
doaj +1 more source