Results 101 to 110 of about 8,749 (208)

Regioselective quinazoline C2 modifications through the azide–tetrazole tautomeric equilibrium

Beilstein Journal of Organic Chemistry
2-Chloro-4-sulfonylquinazolines undergo functional group swap when treated with an azide nucleophile: 1) the azide replaces the sulfonyl group at the C4 position; 2) the intrinsic azide–tetrazole tautomeric equilibrium directs the nucleofugal sulfinate ...
Dāgs Dāvis Līpiņš, Andris Jeminejs, Una Ušacka, Anatoly Mishnev, Māris Turks, Irina Novosjolova   +5 more
doaj   +1 more source

Synthesis and cytotoxicity studies of novel N-arylbenzo[h]quinazolin-2-amines

Beilstein Journal of Organic Chemistry
In this paper, we report a short and efficient synthesis of novel N-arylbenzo[h]quinazoline-2-amines. We have prepared a focused library of nineteen representative examples which have been submitted to cytotoxicity assays against a representative panel ...
Battini Veeraiah, Kishore Ramineni, Dabbugoddu Brahmaiah, Nangunoori Sampath Kumar, Hélène Solhi, Rémy Le Guevel, Chada Raji Reddy, Frédéric Justaud, René Grée   +8 more
doaj   +1 more source

Synthesis of 2,4-Diaminoquinazolines and Tricyclic Quinazolines by Cascade Reductive Cyclization of Methyl N-Cyano-2-nitrobenzimidates

, 2016
An efficient route to N4-substituted 2,4-diaminoquinazolines has been developed by employing tandem condensation of cyanoimidate–amine and reductive cyclization in iron–HCl system.
Yue Chen (73753), Ping Yin (54021), Yong Deng (422212), Nan Liu (1630), Ling He (282204), Yu-Xing Deng (2102680)   +5 more
core   +2 more sources

Copper/Iron-Cocatalyzed Synthesis of Functionalized Quinazolines from gem -Difluoroalkenes and Amidines

A novel and efficient method for synthesizing functionalized acyl quinazolines has been developed via CuCl2·2H2O/FeBr3-cocatalyzed cascade cyclization of amidines with readily accessible gem-difluoroalkenes.
Ying Fu, Yang Feng, Yanpeng Zhang, Zhengyin Du, Xiangxiang Yan   +4 more
core   +1 more source

Design, Synthesis, Pharmacological Evaluation of Quinazolin-4(3H)-Ones Bearing Urea Functionality as Potential VEGFR-2 Inhibitors

Drug Design, Development and Therapy
Mohammad M Al-Sanea,1,* Hani M Hafez,2 Ahmed AB Mohamed,3,* Hamed W El-Shafey,4 Abdullah A Elgazar,5 Samar S Tawfik,4 Wafaa A Ewes,4 Shaimaa Hussein,6 Tariq G Alsahli,6 Abdelrahman Hamdi4 1Department of Pharmaceutical Chemistry, College of ...
Al-Sanea MM, Hafez HM, Mohamed AA, El-Shafey HW, Elgazar AA, Tawfik SS, Ewes WA, Hussein S, Alsahli TG, Hamdi A   +9 more
doaj  

Base-Promoted Synthesis of 2‑Aryl Quinazolines from 2‑Aminobenzylamines in Water

, 2018
A transition-metal-free procedure for the synthesis of a highly valuable class of heteroaromatics, quinazolines, was developed by using easily available 2-aminobenzylamines and α,α,α-trihalotoluenes.
Dong In Kim (5121191), Eun Jin Cho (1554565), Tanmay Chatterjee (1554559)   +2 more
core   +1 more source

Dehydrogenative Synthesis of Quinolines, 2‑Aminoquinolines, and Quinazolines Using Singlet Diradical Ni(II)-Catalysts

, 2019
Simple, straightforward, and atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biomimetic dehydrogenative condensation/coupling reactions, catalyzed by well-defined inexpensive and easy to prepare singlet ...
Gargi Chakraborty, Siuli Das (2819980), Rakesh Mondal (5676512), Rina Sikari, Nanda D. Paul, Rakesh Mondal, Gargi Chakraborty (5676509), Rina Sikari (2819977), Nanda D. Paul (2158771), Seemika Banerjee (6321575), Suman Sinha (2819974), Siuli Das, Seemika Banerjee, Suman Sinha   +13 more
core   +1 more source

Solvent/Oxidant-Switchable Synthesis of Multisubstituted Quinazolines and Benzimidazoles via Metal-Free Selective Oxidative Annulation of Arylamidines

, 2016
A fast and simple divergent synthesis of multisubstituted quinazolines and benzimidazoles was developed from readily available amidines, via iodine­(III)-promoted oxidative C­(sp3)–C­(sp2) and C­(sp2)–N bond formation in nonpolar and polar solvents ...
Jian-Ping Lin (1643410), Feng-Hua Zhang (1796104), Ya-Qiu Long (1643413)   +2 more
core   +1 more source

Ambient and selective synthesis of dihydro-benzimidazoquinazolines in deep eutectic melt of betaine and trichloroacetic acid. [PDF]

RSC Adv
Fadaei Z, Rad-Moghadam K, Pakravan P.
europepmc   +1 more source

Chemical Scaffolds Driving Modern Anticancer Drug Discovery and Radiotheranostics: Structural Determinants, Translational Opportunities and Future Perspectives. [PDF]

Pharmaceuticals (Basel)
Rusek M.
europepmc   +1 more source