Results 91 to 100 of about 8,749 (208)
Proceedings, 2019 Nitrogen-containing heterocycles such as quinazolines and benzofurans have received a great amount of interest in targeted therapies as antitumor drugs [1]. [...]
Marole Maria Maluleka +1 more
doaj +1 more source
Endophytic Fungi Natural Factories of Novel Bioactive Compounds
Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.This review provides a systematic analysis of 242 natural products isolated from 42 genera of endophytic fungi, highlighting their remarkable structural diversity and broad spectrum of biological activities . ABSTRACT Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological ...
Dilmurod Murodullayev +18 more
wiley +1 more source
Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines
, 2018 The first example of the palladium-catalyzed, three-component tandem reaction of 2-aminobenzonitriles, aldehydes, and arylboronic acids has been developed, providing a new approach for one-pot assembly of diverse quinazolines in moderate to good yields ...
Linjun Qi (3603419) +6 more
core +1 more source
Future Journal of Pharmaceutical Sciences, 2016 Quinazoline derivatives are fused heterocyclic ring systems which have been explored for their inhibitory activity towards various protein kinase enzymes and their role as anticancer agents.
Rania S.M. Ismail +3 more
doaj +1 more source
2,4-Disubstituted Quinazolines with Antileishmanial or Antibacterial Activity [PDF]
, 2015 Herein 47 2,4-disubstituted quinazolines were synthesized and tested against Leishmania donovani intracellular amastigotes. A structure-activity relationship was conducted and lead to the identification of quinazolines with EC50s in the single digit and ...
Barber, Megan Marie
core
Traceless Solid-Phase Synthesis of Trisubstituted Quinazolines
, 2015 A traceless polymer-supported synthesis of 4-benzoylquinazolines was developed using the following commercially available building blocks: Fmoc-α-amino acids, 2-nitrobenzensulfonyl chlorides and α-bromoacetophenones.
Megan Fleming (1554235) +5 more
core +1 more source
Nature Communications, 2017 Heterocycles are ubiquitous in bioactive compounds and routes to different substitution patterns are important to access the full substrate space.
Felix E. Held +13 more
doaj +1 more source
, 2019 Rhodium(III)-catalyzed C–H amidation of 2-arylindoles with dioxazolones for the synthesis of indolo[1,2-c]quinazolines is reported. The reaction is compatible with a wide range of electronically diverse 2-arylindoles and dioxazolones, providing indolo
Di Chen (15424) +6 more
core +1 more source
, 2015 A Pd(OAc)2-catalyzed divergent synthesis of multisubstituted imidazoles and quinazolines from N-allylamidines has been developed. In the presence of oxidant O2 from air and/or a ligand and Pd(OAc)2, imidazoles were obtained.
Kaiyan Lou (1566286) +6 more
core +1 more source
Future Journal of Pharmaceutical Sciences, 2015 Background: Molybdenum hydroxylases have been implicated as key oxidative enzymes in some diseases. Methods: Twenty 2-(substituted-thio)-quinazolin-4-one derivatives recently synthesized in our laboratory were examined for their inhibitory activity ...
Hussein I. El-Subbagh +3 more
doaj +1 more source