Results 1 to 10 of about 18,773 (119)

The Role of Selenoproteins SELENOM and SELENOT in the Regulation of Apoptosis, ER Stress, and Calcium Homeostasis in the A-172 Human Glioblastoma Cell Line

Biology, 2022
It is known that seven mammalian selenoproteins are localized in the endoplasmic reticulum: SELENOM, SELENOT, SELENOF, SELENOK, SELENOS, SELENON, and DIO2.
Elena G Varlamova, Egor A Turovsky, Varlamova Elena G   +2 more
exaly   +3 more sources

Development and validation of a machine learning-based survival prediction model for Asian glioblastoma patients using the SEER database and Chinese data [PDF]

Scientific Reports
Glioblastoma is an aggressive, malignant primary brain tumour and the most prevalent histological type of glioma. Our study attempted to investigate the independent predictors of overall survival (OS) and cancer-specific survival (CSS) in Asian patients ...
Denglin Li, Luxin Zhang, Lifei Xu, Renhe Zhai, Hanyu Gao, Junlan Gao, Minghai Wei, Ningwei Che, Yeting He   +8 more
doaj   +2 more sources

Xanthone-1,2,4-triazine and Acridone-1,2,4-triazine Conjugates: Synthesis and Anticancer Activity

Pharmaceuticals, 2023
A total of 21 novel xanthone and acridone derivatives were synthesized using the reactions of 1,2,4-triazine derivatives with 1-hydroxy-3-methoxy-10-methylacridone, 1,3-dimethoxy-, and 1,3-dihydroxanthone, followed by optional dihydrotiazine ring ...
Sougata Santra, Ainur D. Sharapov, Ramil F. Fatykhov, Anastasya P. Potapova, Igor A. Khalymbadzha, Maria I. Valieva, Dmitry S. Kopchuk, Grigory V. Zyryanov, Alexander S. Bunev, Vsevolod V. Melekhin, Vasiliy S. Gaviko, Andrey A. Zonov   +11 more
doaj   +1 more source

Mechanism of Ca²⁺-Dependent Pro-Apoptotic Action of Selenium Nanoparticles, Mediated by Activation of Cx43 Hemichannels

Biology, 2021
To date, there are practically no data on the mechanisms of the selenium nanoparticles action on calcium homeostasis, intracellular signaling in cancer cells, and on the relationship of signaling pathways activated by an increase in Ca2+ in the cytosol ...
Egor A. Turovsky, Elena G. Varlamova
doaj   +1 more source

The Toxicity of Synthetic and Biogenic Selenium Nanoparticles on Human Brain Glioblastoma Cell Line: An in vitro Comparison [PDF]

International Journal of Medical Toxicology and Forensic Medicine, 2020
Background: Brain tumors can be serious and life-threatening when they are treated effectively. Many therapeutic approaches, such as chemotherapy, radiotherapy, and surgery have been used to treat brain tumors.
Shideh Khangholi, Mehdi Mahdavi, Mohammad Hossein Yazdi, Ahmad Reza Shahverdi   +3 more
doaj   +1 more source

Protective potential of piroxicam on human peripheral blood mononuclear cells against the suppressive capacity of glioblastoma cell lines

Scientific Reports, 2022
Dexamethasone, a common medication used in the treatment regimen of glioblastoma, has broad inhibitory effects on the immune responses. Here, in an in vitro study, we examined the effects of piroxicam, a potent substitute for dexamethasone, on peripheral
Jahangir Abdesheikhi, Farnaz Sedghy, Alireza Farsinejad, Merat Mahmoudi, Mahdi ranjkesh, Meysam Ahmadi-Zeidabadi   +5 more
doaj   +1 more source

Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity

Plants, 2021
Based on previous investigations where bis-bibenzyls isolated from liverworts showed various biological activities (cytotoxic, antimicrobial, and antiviral), we investigated their cytotoxic activity in several human cancer cell lines.
Ivana Ivković, Miroslav Novaković, Milan Veljić, Marija Mojsin, Milena Stevanović, Petar D. Marin, Danka Bukvički   +6 more
doaj   +1 more source

Antioxidant and Cytotoxic Activities of Kudzu Roots and Soy Molasses against Pediatric Tumors and Phytochemical Analysis of Isoflavones Using HPLC-DAD-ESI-HRMS

Plants, 2022
Pediatric solid tumors (PSTs) are life-threatening and can lead to high morbidity and mortality rates in children. Developing novel remedies to treat these tumors, such as glioblastoma multiforme and sarcomas, such as osteosarcoma, and rhabdomyosarcoma ...
Saied A. Aboushanab, Vadim A. Shevyrin, Grigory P. Slesarev, Vsevolod V. Melekhin, Anna V. Shcheglova, Oleg G. Makeev, Elena G. Kovaleva, Ki Hyun Kim   +7 more
doaj   +1 more source

Comparative Study of the Anticancer Effects of Selenium Nanoparticles and Selenium Nanorods: Regulation of Ca²⁺ Signaling, ER Stress and Apoptosis

Applied Sciences, 2023
The anti-cancer effects of selenium sources are well known. Among other things, selenium has been shown to have a pleiotropic effect, causing cancer cell death without affecting the healthy cell’s viability, or, in the case of brain cells, has a ...
Elena G. Varlamova, Ilya V. Baimler, Sergey V. Gudkov, Egor A. Turovsky   +3 more
doaj   +1 more source

A 2,5-Dihydroxybenzoic Acid–Gelatin Conjugate Inhibits the Basal and Hsp90-Stimulated Migration and Invasion of Tumor Cells

Journal of Functional Biomaterials, 2020
The extracellular cell surface-associated and soluble heat shock protein 90 (Hsp90) is known to participate in the migration and invasion of tumor cells.
Anastasiya V. Snigireva, Oleg S. Morenkov, Yuri Y. Skarga, Alexander V. Lisov, Zoya A. Lisova, Alexey A. Leontievsky, Mariya A. Zhmurina, Viktoria S. Petrenko, Veronika V. Vrublevskaya   +8 more
doaj   +1 more source